Opportunity Information: Apply for CDC RFA CE16 1606
Apply for CDC RFA CE16 1606
- The HHS-CDC-NCIPC in the health sector is offering a public funding opportunity titled "Prescription Drug Overdose: Data-Driven Prevention Initiative (DDPI)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.136.
- This funding opportunity was created on Mar 25, 2016 and posted on Mar 25, 2016.
- Applicants must submit their applications by May 27, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 16 candidate(s).
- Eligible applicants include: State governments.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The Prescription Drug Overdose: Data-Driven Prevention Initiative (DDPI) is a Centers for Disease Control and Prevention (CDC) cooperative agreement funding opportunity designed to strengthen and evaluate state-level efforts to prevent opioid overuse, misuse, abuse, and overdose. The overall aim is to help states use better data and more targeted prevention strategies to reduce harmful outcomes linked to prescription opioids, including emergency department visits and overdose deaths. The program is built around the idea that states are at different stages in their response to the opioid crisis, so the funding structure allows applicants to pursue either foundational capacity-building work or a more advanced, action-oriented prevention approach.
The opportunity uses a two-tier framework. The first tier, called the Planning and Data (base) component, is intended for states that need to improve core capabilities before they can run a broader prevention program. Under this base option, states are expected to strengthen how they collect, manage, analyze, and apply data related to the opioid epidemic. Just as important, they are expected to engage with communities and partners to develop a practical strategy for scaling up into a larger, more comprehensive prevention program in the future. In other words, this tier is about building the data and planning backbone that allows a state to understand its overdose patterns, identify high-risk populations and geographic hotspots, and plan interventions that fit local conditions.
The second tier, called Prevention in Action (enhanced), is for states that are ready to move beyond planning and put a comprehensive prevention program into operation. States pursuing this enhanced component may apply for both the base Planning and Data work and the implementation funding. The expectation here is more direct impact: implementing prevention activities intended to change the behaviors and conditions that drive prescription opioid dependence and abuse. The CDC frames the desired results in terms of reducing measurable negative health consequences, such as overdose deaths and opioid-related emergency department utilization. Conceptually, this tier supports states that already have enough infrastructure and readiness to translate data into interventions, monitor performance, and demonstrate progress.
Administratively, the DDPI is a discretionary grant offered as a cooperative agreement, meaning the CDC anticipates substantial involvement with awardees during the project rather than a hands-off grant relationship. The funding is categorized under Health and associated with CFDA number 93.136. Eligibility is limited to state governments, reflecting the focus on statewide surveillance capacity, policy levers, and cross-jurisdiction coordination that states can uniquely provide. The sponsoring agency is HHS, specifically the CDC National Center for Injury Prevention and Control (NCIPC), which aligns with overdose prevention as an injury and violence prevention priority area.
Key logistical details from the posted announcement include the funding opportunity number (CDC RFA CE16-1606), an award ceiling of $750,000, and an expectation of 16 awards. The opportunity was posted on March 25, 2016, with an original and current application closing date of May 27, 2016. Overall, DDPI is structured to help states either build the data-driven foundation needed for an effective opioid response or, for more advanced states, to implement and evaluate prevention actions designed to reduce opioid-related harm at the population level.
Frequently Asked Questions (FAQs)
What is the Prescription Drug Overdose: Data-Driven Prevention Initiative (DDPI)?
DDPI is a CDC cooperative agreement funding opportunity designed to strengthen and evaluate state-level efforts to prevent opioid overuse, misuse, abuse, and overdose. It focuses on helping states use improved data and more targeted prevention strategies to reduce harmful outcomes linked to prescription opioids, including emergency department visits and overdose deaths.
What is the overall goal of DDPI?
The overall aim is to help states use better data and more targeted prevention strategies to reduce measurable negative health outcomes associated with prescription opioids, such as opioid-related emergency department utilization and overdose deaths.
How is DDPI structured?
DDPI uses a two-tier framework. Applicants may pursue either (1) a foundational, capacity-building approach focused on planning and data, or (2) a more advanced approach that includes implementing comprehensive prevention activities (in addition to planning and data work).
What are the two tiers/components of DDPI?
The two tiers are:
- Planning and Data (base): Focused on strengthening core data and planning capabilities.
- Prevention in Action (enhanced): For states ready to implement a comprehensive prevention program; states pursuing this component may apply for both base and implementation funding.
What is the Planning and Data (base) component intended to support?
The base component is intended for states that need to improve core capabilities before running a broader prevention program. It emphasizes strengthening how the state collects, manages, analyzes, and applies opioid-related data, and engaging communities and partners to develop a practical strategy to scale up into a more comprehensive prevention program in the future.
What kinds of capacity improvements are emphasized under the base component?
Under the Planning and Data (base) option, states are expected to strengthen their ability to collect, manage, analyze, and apply data related to the opioid epidemic so they can understand overdose patterns, identify high-risk populations and geographic hotspots, and plan interventions that fit local conditions.
Does the base component include partner or community engagement?
Yes. In addition to improving data capabilities, the base component expects states to engage communities and partners and develop a practical strategy for scaling up to a larger prevention program.
What is the Prevention in Action (enhanced) component?
The enhanced component is intended for states ready to move beyond planning and put a comprehensive prevention program into operation. The expectation is more direct impact through implementation of prevention activities aimed at changing behaviors and conditions that drive prescription opioid dependence and abuse.
Can a state apply for both the base and enhanced components?
Yes. States pursuing the Prevention in Action (enhanced) component may apply for both the Planning and Data (base) work and the implementation funding.
What results does the CDC expect from the enhanced component?
The CDC frames desired results in terms of reducing measurable negative health consequences, including overdose deaths and opioid-related emergency department utilization. The enhanced component supports states that can translate data into interventions, monitor performance, and demonstrate progress.
What type of funding opportunity is DDPI?
DDPI is a discretionary grant offered as a cooperative agreement. This means CDC anticipates substantial involvement with awardees during the project, rather than a fully hands-off grant relationship.
Which federal agency sponsors this opportunity?
The sponsoring department is HHS, and the specific agency is the Centers for Disease Control and Prevention (CDC), through the National Center for Injury Prevention and Control (NCIPC).
Who is eligible to apply?
Eligibility is limited to state governments. This reflects the program's focus on statewide surveillance capacity, policy levers, and cross-jurisdiction coordination that states can provide.
What is the funding opportunity number?
The funding opportunity number is CDC RFA CE16-1606.
What is the CFDA number for this program?
The CFDA number associated with DDPI is 93.136.
What is the award ceiling?
The posted award ceiling is $750,000.
How many awards are expected?
The announcement indicates an expectation of 16 awards.
When was the opportunity posted?
The opportunity was posted on March 25, 2016.
What is the application deadline?
The original and current application closing date listed is May 27, 2016.
What makes DDPI "data-driven"?
DDPI emphasizes improving and using opioid-related data to understand overdose patterns, identify high-risk populations and geographic hotspots, and then plan or implement interventions that are targeted to local conditions and can be monitored for performance and impact.
Why does DDPI have a two-tier approach?
The program is built around the idea that states are at different stages in their response to the opioid crisis. The two-tier structure allows states to pursue either foundational capacity-building (Planning and Data) or a more advanced, action-oriented prevention approach (Prevention in Action), depending on readiness and infrastructure.
What outcomes does DDPI aim to reduce?
DDPI is intended to reduce harmful outcomes linked to prescription opioids, specifically including emergency department visits and overdose deaths.
What does CDC involvement look like under a cooperative agreement?
Because DDPI is a cooperative agreement, CDC anticipates substantial involvement with awardees during the project period, rather than operating as a purely hands-off funder.
Is this opportunity categorized under a specific sector or topic area?
Yes. The funding is categorized under Health, and it aligns with CDC NCIPC priorities, framing overdose prevention as part of injury prevention.
Browse more opportunities from the same category: Health
Next opportunity: Notice of Intent to Award: Theodore Roosevelt Inaugural Site - Operations and Management
Previous opportunity: NOTICE OF INTENT TO AWARD - Upper Housatonic Valley National Heritage Area
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for CDC RFA CE16 1606
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (CDC RFA CE16 1606) also looked into and applied for these:
| Funding Opportunity |
|---|
| PPHF 2016: Immunization Grants - Increasing IIS Sentinel Site Capacity for Enhanced Program Support – Financed in part by 2016 Prevention and Public Health Funds Apply for CDC RFA IP14 140703CONTPPHF16 Funding Number: CDC RFA IP14 140703CONTPPHF16 Agency: HHS-CDC-NCIRD Category: Health Funding Amount: Case Dependent |
| PPHF 2016: Epidemiology and Laboratory Capacity Program – Emerging Infections Programs – Financed in part by 2016 Prevention and Public Health Funds Apply for CDC RFA CK12 120905CONTPPHF16 Funding Number: CDC RFA CK12 120905CONTPPHF16 Agency: HHS-CDC-NCEZID Category: Health Funding Amount: Case Dependent |
| Collecting Violent Death Information Using the National Violent Death Reporting System (NVDRS) Apply for CDC RFA CE16 1607 Funding Number: CDC RFA CE16 1607 Agency: HHS-CDC-NCIPC Category: Health Funding Amount: $878,000 |
| Tailoring Dental Treatment for Individuals with Systemic Diseases that Compromise Oral Health (R01) Apply for PAR 16 154 Funding Number: PAR 16 154 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Tailoring Dental Treatment for Individuals with Systemic Diseases that Compromise Oral Health (R21) Apply for PAR 16 153 Funding Number: PAR 16 153 Agency: HHS-NIH11 Category: Health Funding Amount: $200,000 |
| NeuroNEXT Clinical Trials (U01) Apply for PAR 16 155 Funding Number: PAR 16 155 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Newborn Screening Implementation Program Regarding Conditions Added to the Recommended Uniform Screening Panel (RUSP) Apply for HRSA 16 062 Funding Number: HRSA 16 062 Agency: HHS-HRSA Category: Health Funding Amount: Case Dependent |
| Use of Imaging and Digital Image Analysis Software/s to Evaluate Transdermal Irritation and Non - inferiority of Generic Transdermal Products (U01) Apply for RFA FD 16 010 Funding Number: RFA FD 16 010 Agency: HHS-NIH11 Category: Health Funding Amount: $250,000 |
| Generic Drug Substitution in Special Populations (U01) Apply for RFA FD 16 011 Funding Number: RFA FD 16 011 Agency: HHS-NIH11 Category: Health Funding Amount: $200,000 |
| Adult Maturational Changes and Dysfunctions in Emotion Regulation (R01) Apply for RFA MH 17 405 Funding Number: RFA MH 17 405 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Preventing Teen Dating and Youth Violence by Addressing Shared Risk and Protective Factors Apply for CDC RFA CE16 1605 Funding Number: CDC RFA CE16 1605 Agency: HHS-CDC-NCIPC Category: Health Funding Amount: $412,500 |
| TRANSFORM/Primary Health Care Unit (PHCU) Apply for APS 663 16 000005 Funding Number: APS 663 16 000005 Agency: USAID-ETH Category: Health Funding Amount: $120,000,000 |
| NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00) Apply for PAR 16 156 Funding Number: PAR 16 156 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Targeted Capacity Expansion: Medication Assisted Treatment - Prescription Drug and Opioid Addiction (MAT-PDOA) grants Apply for TI 16 014 Funding Number: TI 16 014 Agency: HHS-SAMHS Category: Health Funding Amount: $1,000,000 |
| Prevention Innovation Program III (PIP) (R01) Apply for RFA AI 16 025 Funding Number: RFA AI 16 025 Agency: HHS-NIH11 Category: Health Funding Amount: $400,000 |
| National Implementation and Dissemination for Chronic Disease Prevention Apply for CDC RFA DP14 141803CONT16 Funding Number: CDC RFA DP14 141803CONT16 Agency: HHS-CDC Category: Health Funding Amount: Case Dependent |
| Strategic Prevention Framework for Prescription Drugs (SPF Rx) Apply for SP 16 006 Funding Number: SP 16 006 Agency: HHS-SAMHS Category: Health Funding Amount: $371,616 |
| Grants to Prevent Prescription Drug/Opioid Overdose-Related Deaths (PDO) Apply for SP 16 005 Funding Number: SP 16 005 Agency: HHS-SAMHS Category: Health Funding Amount: $11,000,000 |
| Partnerships for Countermeasures against Select Pathogens (R01) Apply for RFA AI 16 034 Funding Number: RFA AI 16 034 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| HPV Roundtable: Creating a National Network of Partners to Promote Cancer Prevention through Human Papillomavirus Vaccination- Financed in Part by 2016 Prevention and Public Health Funds Apply for CDC RFA IP16 1602PPHF16 Funding Number: CDC RFA IP16 1602PPHF16 Agency: HHS-CDC-NCIRD Category: Health Funding Amount: $500,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants

Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "CDC RFA CE16 1606", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.
