Opportunity Information: Apply for RFA DK 14 004
Apply for RFA DK 14 004
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Prevention of Lower Urinary Tract Symptoms in Women Bladder Health Clinical Centers (PLUS CCs) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.313 NIH Office of Research on Womens Health 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Aug 18, 2014 and posted on Aug 18, 2014.
- Applicants must submit their applications by Nov 20, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Private institutions of higher education Special district governments Public housing authorities/Indian housing authorities Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal governments (Federally recognized) City or township governments Public and State controlled institutions of higher education County governments For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Prevention of Lower Urinary Tract Symptoms in Women Bladder Health Clinical Centers (PLUS CCs) (U01) funding opportunity (RFA-DK-14-004) was a National Institutes of Health cooperative agreement announcement designed to build a coordinated, multi-center, multidisciplinary research consortium called the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium. The central purpose was to shift NIH-supported work in this area from mainly treating women who already have lower urinary tract symptoms (LUTS) toward understanding how LUTS start and how they might be prevented in the first place. NIH highlighted that, at the time of the announcement, the field lacked enough basic evidence about healthy bladder function and modifiable risk factors to justify large-scale primary or secondary prevention trials. In practical terms, the FOA aimed to fund the foundational clinical and population research needed to make future prevention interventions scientifically sound and feasible.
The main objective of the program was to have funded clinical centers collaboratively plan, conduct, and analyze research studies that establish the evidence base for prevention. That includes defining what "normal" or "healthy" bladder function looks like across different life stages, and identifying behavioral, environmental, psychosocial, biologic, and other risk factors that may contribute to LUTS and related conditions. The consortium emphasis was broad and prevention-oriented rather than limited to any single disease mechanism or treatment comparison. The FOA specifically pointed to symptom groups and conditions commonly associated with LUTS, including symptoms tied to bladder infection diagnoses, urinary incontinence, voiding dysfunction, overactive bladder, and interstitial cystitis/bladder pain syndrome. By mapping symptom development and correlates over time, the consortium was expected to create a platform that could later support well-targeted prevention trials.
A notable feature of the program was its life-course focus. The consortium was expected to study a wide age range, from adolescent girls through older, non-institutionalized women. That framing reflects an interest in when bladder health trajectories begin to diverge, which risk factors emerge at different points in life, and which of those risks might be practical targets for prevention. The program concept is essentially: before testing interventions, the field needs better definitions, better measurement approaches, and stronger observational and mechanistic evidence about what predicts the onset and progression of LUTS in real-world populations.
From an administrative and funding standpoint, this opportunity used the U01 cooperative agreement mechanism, meaning NIH anticipated substantial programmatic involvement and coordination compared with a standard research project grant. The opportunity category was discretionary, and the activity area was listed under health-related research. The estimated total funding was about $4.5 million, with an award ceiling of $500,000 (as published in the summary data). There was no cost sharing or matching requirement stated.
Eligibility was intentionally broad and included many types of domestic applicants such as public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) entities), small businesses, for-profit organizations (other than small businesses), and a range of governmental entities (state, county, city/township, special district governments, and certain housing authorities). The eligibility language also explicitly included a wide set of mission-focused institutions and organizations, such as Historically Black Colleges and Universities, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, Asian American and Native American Pacific Islander-serving institutions, faith-based and community-based organizations, and tribal governments (including both federally recognized and other tribal entities). Foreign organizations and foreign components were also allowed under NIH policy as described, including non-U.S. institutions, non-U.S. components of U.S. organizations, and other foreign components consistent with the NIH Grants Policy Statement.
Key dates in the published record show it was posted on August 18, 2014, with an original and current closing date of November 20, 2014, and an archive date of December 21, 2014. The sponsoring agency was NIH, with the catalog numbers indicating involvement aligned with the National Institute of Diabetes and Digestive and Kidney Diseases and related NIH research areas, including the NIH Office of Research on Women’s Health and aging research. The full announcement was made available through NIH’s grants guide (link provided in the source), and NIH’s Office of Extramural Research web support contacts were provided for access and technical linking issues.
FAQs: Prevention of Lower Urinary Tract Symptoms in Women Bladder Health Clinical Centers (PLUS CCs) (U01) - RFA-DK-14-004
What is this funding opportunity?
This was a National Institutes of Health (NIH) cooperative agreement funding opportunity titled "The Prevention of Lower Urinary Tract Symptoms in Women Bladder Health Clinical Centers (PLUS CCs) (U01)" under FOA number RFA-DK-14-004. It was designed to establish a coordinated, multi-center, multidisciplinary research consortium known as the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium.
What was the main purpose of the program?
The central purpose was to shift NIH-supported work from primarily treating women who already have lower urinary tract symptoms (LUTS) toward understanding how LUTS begin and how they could be prevented. The program aimed to fund foundational clinical and population research needed to support scientifically sound and feasible prevention approaches in the future.
Why was foundational research emphasized instead of prevention trials?
NIH highlighted that the field did not yet have enough basic evidence about healthy bladder function and modifiable risk factors to justify large-scale primary or secondary prevention trials. The intent was to build the evidence base first, including better definitions, better measurement approaches, and stronger observational and mechanistic evidence about predictors of LUTS onset and progression.
What were the main research objectives for funded clinical centers?
The program objective was for funded clinical centers to collaboratively plan, conduct, and analyze research studies that establish the evidence base for prevention. This included defining "normal" or "healthy" bladder function across life stages and identifying behavioral, environmental, psychosocial, biologic, and other risk factors that may contribute to LUTS and related conditions.
What kinds of symptoms and conditions were within scope?
The FOA pointed to symptom groups and conditions commonly associated with LUTS, including symptoms tied to bladder infection diagnoses, urinary incontinence, voiding dysfunction, overactive bladder, and interstitial cystitis/bladder pain syndrome. The overall emphasis was broad and prevention-oriented rather than limited to a single mechanism or treatment comparison.
What does "life-course focus" mean in this program?
The consortium was expected to study bladder health across a wide age range, from adolescent girls through older, non-institutionalized women. This framing reflects interest in when bladder health trajectories begin to diverge, how risk factors emerge at different points in life, and which risks might be practical targets for prevention.
How was the PLUS Research Consortium expected to support future prevention efforts?
By mapping symptom development and correlates over time and strengthening definitions and measurement of bladder health, the consortium was expected to create a platform that could later support well-targeted prevention trials.
What funding mechanism was used for this opportunity?
This opportunity used the U01 cooperative agreement mechanism. That means NIH anticipated substantial programmatic involvement and coordination compared with a standard research project grant.
How much funding was available?
The estimated total funding was about $4.5 million. The published award ceiling was $500,000 (as listed in the summary data).
Was cost sharing or matching required?
No cost sharing or matching requirement was stated for this opportunity.
Who was eligible to apply?
Eligibility was broad and included many types of domestic applicants, such as public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) organizations), small businesses, for-profit organizations (other than small businesses), and governmental entities (including state, county, city/township, special district governments, and certain housing authorities).
Were mission-focused institutions explicitly included in eligibility?
Yes. The eligibility language explicitly included a wide set of mission-focused institutions and organizations, including Historically Black Colleges and Universities, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, Asian American and Native American Pacific Islander-serving institutions, faith-based and community-based organizations, and tribal governments (both federally recognized and other tribal entities).
Were foreign organizations or foreign components allowed?
Yes. Foreign organizations and foreign components were allowed under NIH policy as described, including non-U.S. institutions, non-U.S. components of U.S. organizations, and other foreign components consistent with the NIH Grants Policy Statement.
What was the opportunity category and activity area?
The opportunity category was discretionary, and the activity area was listed under health-related research.
Which agency sponsored this opportunity?
The sponsoring agency was the National Institutes of Health (NIH). The catalog numbers indicated involvement aligned with the National Institute of Diabetes and Digestive and Kidney Diseases and related NIH research areas, including the NIH Office of Research on Women's Health and aging research.
When was the opportunity posted and when did it close?
It was posted on August 18, 2014. The original and current closing date was November 20, 2014. The archive date was December 21, 2014.
Where was the full announcement published?
The full announcement was made available through NIH's grants guide (as indicated by the source information), and NIH's Office of Extramural Research web support contacts were provided for access and technical linking issues.
Is this funding opportunity still active?
Based on the listed closing date (November 20, 2014) and archive date (December 21, 2014), this opportunity is not active in the published record provided.
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