Opportunity Information: Apply for RFA DK 14 018
Apply for RFA DK 14 018
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Prevention of Lower Urinary Tract Symptoms in Women Bladder Health Scientific and Data Coordinating Center (PLUS SDCC) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.313 NIH Office of Research on Womens Health 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Aug 18, 2014 and posted on Aug 18, 2014.
- Applicants must submit their applications by Nov 20, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Independent school districts City or township governments Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Small businesses County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Prevention of Lower Urinary Tract Symptoms in Women Bladder Health Scientific and Data Coordinating Center (PLUS SDCC) (U01) funding opportunity (RFA-DK-14-018) is an NIH cooperative agreement designed to launch and support a multi-center, multidisciplinary research consortium called the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium. The main shift in this program is strategic: instead of concentrating primarily on treating women who already have established lower urinary tract symptoms (LUTS), NIH is pushing the field toward prevention. The FOA is based on the premise that large-scale prevention trials are not yet feasible because the basic scientific foundation is still incomplete. In other words, there is not enough consolidated evidence about what "healthy" bladder function looks like across the life course, nor enough clarity about which modifiable behaviors and exposures increase risk for common LUTS-related conditions.
The core purpose of the initiative is to plan, carry out, and analyze the types of foundational studies needed to support future prevention interventions. This includes building a stronger evidence base for normal bladder health and identifying behavioral and other risk factors that may contribute to LUTS and related conditions. The consortium is intended to generate knowledge that can later be used to design effective primary prevention strategies (preventing LUTS before they start) and secondary prevention strategies (preventing progression, recurrence, or complications once early symptoms appear). The research focus is broad and is meant to capture the real-life spectrum of bladder health rather than being limited to clinical populations alone.
A defining feature of the program is its life-course approach. The consortium is expected to study bladder health and LUTS risk across a wide age range, from adolescent girls through older, non-institutionalized women. This emphasis reflects the idea that risk factors and protective behaviors may begin early, change over time, and accumulate across key transitions such as puberty, pregnancy, childbirth, menopause, aging, and evolving health conditions. The consortium also targets symptoms and symptom clusters that commonly overlap with or are associated with diagnoses like bladder infections, urinary incontinence, voiding dysfunction, overactive bladder, and interstitial cystitis/bladder pain syndrome. By treating these symptom domains as part of a broader bladder health landscape, the consortium aims to clarify pathways into disease and identify points where prevention may be most realistic and impactful.
Mechanistically, the award uses the U01 cooperative agreement mechanism, which typically means NIH expects substantial scientific involvement with the awardees compared with a standard investigator-initiated grant. The "Scientific and Data Coordinating Center" concept signals that the funded effort is not simply a single research project; it is infrastructure plus leadership that helps coordinate multi-site work, harmonize methods, manage data, and support consistent analysis across studies within the consortium. The overall intent is to produce comparable, high-quality evidence that can serve as a platform for later, more definitive prevention trials.
From an administrative and funding standpoint, the opportunity was posted August 18, 2014, with an original and current closing date of November 20, 2014, and an archive date of December 21, 2014. NIH listed an estimated total funding amount of $4.5 million and an award ceiling of $750,000. There is no cost sharing or matching requirement. The activity category is listed under health-related research programs, including NIH components and associated CFDA listings such as 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), 93.313 (NIH Office of Research on Women's Health), and 93.866 (Aging Research), reflecting the cross-cutting relevance of bladder health to women's health and aging.
Eligibility is intentionally broad, allowing a wide range of organizations to apply. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), state and local governments, tribal governments and tribal organizations, special district governments, independent school districts, public housing authorities/Indian housing authorities, small businesses, and for-profit organizations (other than small businesses). The FOA also explicitly includes several mission-driven and capacity-building institution types (for example, HBCUs, Hispanic-serving institutions, AANAPISIs, TCCUs, Alaska Native and Native Hawaiian Serving Institutions), as well as faith-based and community-based organizations. Importantly, non-U.S. entities are eligible, including foreign organizations and foreign institutions, and foreign components of U.S. organizations are allowed as defined by NIH policy. This broad eligibility aligns with the consortium model, where diverse partners can contribute clinical expertise, epidemiology, behavioral science, data science, and community engagement across different populations and settings.
The sponsoring agency is the National Institutes of Health. For applicants or readers unable to access the full announcement online or encountering technical issues, the FOA provides contact information for the NIH Office of Extramural Research (OER) webmaster via FBOWebmaster@OD.NIH.GOV, and it links to the full announcement at http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-14-018.html.
FAQs: Prevention of Lower Urinary Tract Symptoms in Women Bladder Health Scientific and Data Coordinating Center (PLUS SDCC) (U01)
What is this funding opportunity?
This is an NIH cooperative agreement funding opportunity for the Prevention of Lower Urinary Tract Symptoms in Women Bladder Health Scientific and Data Coordinating Center (PLUS SDCC) (U01), listed as RFA-DK-14-018.
What is the PLUS Research Consortium?
The Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium is a planned multi-center, multidisciplinary research consortium intended to build the foundational science needed to support future prevention strategies for lower urinary tract symptoms (LUTS) in women.
What is the main strategic shift emphasized by NIH in this program?
The program pushes the field away from focusing primarily on treatment of women with established LUTS and toward prevention, including generating the evidence needed to support future prevention interventions.
Why does the FOA emphasize foundational studies instead of large-scale prevention trials right now?
The FOA is based on the premise that large-scale prevention trials are not yet feasible because the underlying scientific foundation is still incomplete. The initiative aims to address gaps such as limited consolidated evidence about what healthy bladder function looks like across the life course and unclear understanding of modifiable behaviors and exposures that increase risk.
What is the core purpose of the initiative?
The core purpose is to plan, carry out, and analyze foundational studies that can support future prevention interventions. This includes strengthening the evidence base for normal bladder health and identifying behavioral and other risk factors that may contribute to LUTS and related conditions.
What kinds of prevention does the program aim to support in the future?
The consortium is intended to generate knowledge that can later be used to design primary prevention strategies (preventing LUTS before they start) and secondary prevention strategies (preventing progression, recurrence, or complications once early symptoms appear).
How broad is the research focus?
The research focus is described as broad and intended to capture the real-life spectrum of bladder health rather than being limited to clinical populations alone.
What does a life-course approach mean in this program?
A life-course approach means the consortium is expected to study bladder health and LUTS risk across a wide age range, from adolescent girls through older, non-institutionalized women, recognizing that risk factors and protective behaviors can begin early, change over time, and accumulate across life transitions.
Which life stages or transitions are highlighted as relevant to bladder health and LUTS risk?
The FOA highlights key transitions such as puberty, pregnancy, childbirth, menopause, aging, and evolving health conditions as points where risk factors and protective behaviors may change and accumulate.
What symptoms or symptom clusters are within scope?
The program targets symptoms and symptom clusters that commonly overlap with or are associated with diagnoses such as bladder infections, urinary incontinence, voiding dysfunction, overactive bladder, and interstitial cystitis/bladder pain syndrome.
How does the consortium view these symptom domains?
The consortium treats these symptom domains as part of a broader bladder health landscape, with the goal of clarifying pathways into disease and identifying realistic and impactful points for prevention.
What funding mechanism is used and what does it imply?
The award uses the U01 cooperative agreement mechanism, which typically means NIH expects substantial scientific involvement with the awardees compared with a standard investigator-initiated grant.
What is a Scientific and Data Coordinating Center (SDCC) in the context of this FOA?
The SDCC concept indicates the funded effort is intended to provide infrastructure and leadership to coordinate multi-site work, harmonize methods, manage data, and support consistent analysis across studies within the consortium.
Is this opportunity for a single research project or something broader?
Based on the SDCC description, the funded effort is not described as a single standalone research project; it is described as infrastructure plus leadership supporting coordinated, multi-site consortium work.
What is the overall intent of coordinating methods and data across sites?
The intent is to produce comparable, high-quality evidence that can serve as a platform for later, more definitive prevention trials.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
When was the opportunity posted and what are the key dates listed?
The opportunity was posted on August 18, 2014. The original and current closing date is November 20, 2014. The archive date is December 21, 2014.
How much funding is available and what is the award ceiling?
NIH listed an estimated total funding amount of $4.5 million and an award ceiling of $750,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What activity category is this opportunity listed under?
The activity category is listed under health-related research programs, including NIH components and associated CFDA listings reflecting the cross-cutting relevance of bladder health to women's health and aging.
Which CFDA listings are associated with this opportunity?
The information provided references CFDA listings such as 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), 93.313 (NIH Office of Research on Women's Health), and 93.866 (Aging Research).
Who is eligible to apply?
Eligibility is broad. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), state and local governments, tribal governments and tribal organizations, special district governments, independent school districts, public housing authorities/Indian housing authorities, small businesses, and for-profit organizations (other than small businesses).
Are mission-driven and capacity-building institutions included in eligibility?
Yes. The FOA explicitly includes institution types such as HBCUs, Hispanic-serving institutions, AANAPISIs, TCCUs, and Alaska Native and Native Hawaiian Serving Institutions, and also includes faith-based and community-based organizations.
Are non-U.S. entities eligible to apply?
Yes. Non-U.S. entities are eligible, including foreign organizations and foreign institutions, and foreign components of U.S. organizations are allowed as defined by NIH policy.
Why might the FOA allow such broad eligibility?
The broad eligibility aligns with the consortium model described, where diverse partners can contribute clinical expertise, epidemiology, behavioral science, data science, and community engagement across different populations and settings.
Where can the full announcement be found?
The FOA links to the full announcement at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-14-018.html
Who should be contacted if there are technical issues accessing the announcement?
The FOA provides contact information for the NIH Office of Extramural Research (OER) webmaster via FBOWebmaster@OD.NIH.GOV.
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