Opportunity Information: Apply for RFA DP10 003ARRA10
Apply for RFA DP10 003ARRA10
- The Centers for Disease Control and Prevention in the health sector is offering a public funding opportunity titled "Prevention Research Centers Comparative Effectiveness Research Program U48" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.730 ARRA Prevention Research Centers Comparative Effectiveness Research Program.
- This funding opportunity was created on Mar 22, 2010 and posted on Feb 25, 2010.
- Applicants must submit their applications by Mar 25, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $10,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 37 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- The following organizations/institutions are eligible to apply. Consistent with the purposes of the Recovery Act (in particular, to preserve and create jobs and promote economic recovery in the United States, and to provide investments needed to increase economic efficiency by spurring technological advances in science and health), applicants must be a domestic (United States) institution/organization of one of the types listed below. The United States institution/organization must be located in the 50 states, or in the territories and possessions of the U.S., Commonwealth of Puerto Rico, Trust Territory of the Pacific Islands, or District of Columbia. Foreign organizations/institutions are not permitted as the applicant organization. The HHS ARRA Spend Plan for this CDC program limits eligibility only to applicants who have applied for and have been selected as Prevention Research Centers under CDC Program Announcement DP 09 001. Competition is limited to PRCs under this CDC Program Announcement because (1) they are uniquely positioned to perform, oversee, and coordinate public health oriented CER that promotes the field of prevention research due to their established relationships with community partners and previous experience with CER and (2) these PRCs recently competed for prevention research funding and were deemed to be the best applicants among research institutions that include all schools of public health and schools of medicine with preventive medicine residency programs. The 37 currently funded PRCs at the following institutions are eligible to apply for this FOA 1. Boston University 2. Case Western Reserve University 3. Columbia University 4. Dartmouth College 5. Emory University 6. Harvard University 7. Johns Hopkins University 8. Morehouse School of Medicine 9. New York University School of Medicine 10. Ohio State University 11. Oregon Health and Science University 12. Saint Louis University (with Washington University) 13. San Diego State University (with University of California at San Diego) 14. Texas AM Health Science Center 15. Tulane University 16. University of Alabama at Birmingham 17. University of Arizona 18. University of Arkansas for Medical Sciences 19. University of California at Berkeley 20. University of California at Los Angeles 21. University of Colorado Denver 22. University of Kentucky 23. University of Maryland 24. University of Massachusetts Medical School 25. University of Michig
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Opportunity Summary:
The Prevention Research Centers Comparative Effectiveness Research Program U48 (Funding Opportunity Number RFA-DP10-003ARRA10) was a CDC discretionary cooperative agreement opportunity designed to fund comparative effectiveness research (CER) led by existing CDC-funded Prevention Research Centers (PRCs). Backed by American Recovery and Reinvestment Act of 2009 (ARRA) funds, the program aimed to accelerate practical, prevention-focused evidence by directly comparing innovative public health strategies or interventions. A central theme was testing what works best, for whom, and under what real-world conditions, especially when approaches are implemented in new settings or among populations that are often underrepresented in research, including racial and ethnic minority groups and people with disabilities.
The research focus emphasized CER that goes beyond traditional clinical comparisons and instead evaluates population-level prevention strategies. Applicants were encouraged to study interventions that operate through policy and environmental change, such as community design, food and physical activity environments, organizational practices, or other structural levers that can influence health behaviors and outcomes at scale. The FOA also encouraged the use of new or expanded endpoints, including biologic measures and projects that blend clinical and social interventions. At the same time, the announcement set an important condition: if biologic measures were included, applicants were expected to pair them with related, validated, or generally accepted health outcomes in the same proposal, reinforcing that biomarkers should be tied to meaningful health impacts rather than used in isolation.
The funding instrument was a U48 cooperative agreement, which typically indicates substantial involvement from the CDC in areas such as scientific coordination, guidance, and programmatic oversight, rather than a hands-off grant. The opportunity was categorized under the health funding activity area (CFDA 93.730) and projected up to 37 awards, aligning with the number of currently funded PRCs eligible to apply. The CDC listed an estimated total funding amount of $10,000,000. The funding notice did not specify an award floor or ceiling in the provided data, suggesting amounts may have varied by proposal scope and budget justification within CDC and ARRA constraints.
Eligibility was tightly restricted. Only domestic U.S. institutions that had applied for and been selected as PRCs under CDC Program Announcement DP09-001 could apply, and foreign institutions were not allowed as applicants. This limitation was justified in the FOA on the grounds that PRCs already had established community partnerships and relevant infrastructure, and had recently been competitively selected as leading prevention research institutions capable of conducting and coordinating public health-oriented CER. The eligible applicants were the 37 currently funded PRCs housed at specified universities and medical schools (examples included Boston University, Columbia University, Emory University, Harvard University, Johns Hopkins University, Morehouse School of Medicine, and multiple major state universities and University of California campuses), reflecting a national network positioned to conduct multi-setting prevention research with community engagement.
From an administrative standpoint, the opportunity was posted February 25, 2010, created March 22, 2010, and had a very short application window with an original closing date of March 22, 2010, later reflected as March 25, 2010, before being archived April 21, 2010. There was no cost sharing or matching requirement. For technical access issues, the notice directed applicants to the CDC Procurement and Grants Technical Information Management Section (phone 770-488-2700).
FAQs: Prevention Research Centers Comparative Effectiveness Research Program U48 (RFA-DP10-003ARRA10)
What is this funding opportunity?
This was a CDC discretionary cooperative agreement opportunity titled the Prevention Research Centers Comparative Effectiveness Research (CER) Program U48, under Funding Opportunity Number RFA-DP10-003ARRA10. It was designed to support comparative effectiveness research led by existing CDC-funded Prevention Research Centers (PRCs).
What was the main goal of the program?
The goal was to accelerate practical, prevention-focused evidence by directly comparing innovative public health strategies or interventions. A central theme was identifying what works best, for whom, and under what real-world conditions, especially when interventions are implemented in new settings or among populations often underrepresented in research.
What type of research was this program trying to fund?
The program emphasized comparative effectiveness research (CER) focused on population-level prevention strategies, rather than traditional clinical comparisons. It aimed to evaluate prevention approaches that can influence health behaviors and outcomes at scale.
What kinds of interventions were encouraged?
Applicants were encouraged to study interventions operating through policy and environmental change. Examples of the types of structural levers highlighted included community design, food and physical activity environments, organizational practices, and other policy or environmental strategies that can affect health at the population level.
Was the program limited to clinical interventions?
No. The opportunity specifically emphasized CER that goes beyond traditional clinical comparisons and instead evaluates population-level prevention strategies. It also encouraged projects that blend clinical and social interventions.
Did the FOA encourage any specific outcomes or endpoints?
Yes. The FOA encouraged the use of new or expanded endpoints, including biologic measures, and also supported projects that combine clinical and social approaches to prevention.
If a project included biologic measures, were there extra requirements?
Yes. If biologic measures (biomarkers) were included, applicants were expected to pair them with related, validated, or generally accepted health outcomes in the same proposal. The intent was that biomarkers should be tied to meaningful health impacts and not used on their own.
What populations were highlighted as priorities for real-world testing?
The program emphasized understanding effectiveness in real-world conditions, especially in new settings or among populations often underrepresented in research, including racial and ethnic minority groups and people with disabilities.
What was the funding mechanism?
The funding mechanism was a U48 cooperative agreement.
What does a U48 cooperative agreement imply about CDC involvement?
A U48 cooperative agreement typically indicates substantial CDC involvement, such as scientific coordination, guidance, and programmatic oversight, rather than a hands-off grant structure.
What was the CFDA number and activity area?
The opportunity fell under the health funding activity area and was listed under CFDA 93.730.
How much total funding was estimated for this opportunity?
The CDC listed an estimated total funding amount of $10,000,000.
How many awards were anticipated?
Up to 37 awards were projected, aligning with the number of currently funded PRCs eligible to apply.
Was there a minimum or maximum award amount stated?
No award floor or ceiling was specified in the provided information. This suggests award amounts may have varied based on proposal scope and budget justification within CDC and ARRA constraints.
Was cost sharing or matching required?
No. The opportunity stated there was no cost sharing or matching requirement.
Who was eligible to apply?
Eligibility was tightly restricted to domestic U.S. institutions that had applied for and been selected as PRCs under CDC Program Announcement DP09-001. Only the 37 currently funded PRCs were eligible.
Could a foreign institution apply?
No. Foreign institutions were not allowed as applicants.
Why was eligibility limited to existing Prevention Research Centers?
The FOA justified the restriction by noting that PRCs already had established community partnerships and relevant infrastructure, and had recently been competitively selected as leading prevention research institutions capable of conducting and coordinating public health-oriented CER.
What types of institutions hosted eligible PRCs?
The eligible PRCs were housed at universities and medical schools across the United States. Examples mentioned included Boston University, Columbia University, Emory University, Harvard University, Johns Hopkins University, Morehouse School of Medicine, and multiple major state universities and University of California campuses.
What was the funding source connected to this program?
The program was backed by American Recovery and Reinvestment Act of 2009 (ARRA) funds.
When was the opportunity posted and when did it close?
The opportunity was posted February 25, 2010, created March 22, 2010, and had a very short application window. The original closing date was March 22, 2010, later reflected as March 25, 2010. It was archived April 21, 2010.
What should applicants do if they had technical access issues?
For technical access issues, applicants were directed to the CDC Procurement and Grants Technical Information Management Section at 770-488-2700.
Is this opportunity still open?
No. Based on the provided information, the opportunity was archived on April 21, 2010.
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