Opportunity Information: Apply for CDC RFA GH11 11500503SUPP16
Apply for CDC RFA GH11 11500503SUPP16
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Program Expansion Supplement: Provision of Male Medical Circumcision (MMC) in South Africa under PEPFAR" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Aug 18, 2016.
- Applicants must submit their applications by Oct 17, 2016 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $5,489,235.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The grant opportunity titled "Program Expansion Supplement: Provision of Male Medical Circumcision (MMC) in South Africa under PEPFAR" is a CDC funding announcement designed to expand voluntary medical male circumcision (VMMC) services in South Africa as a core HIV prevention strategy. It is based on strong scientific evidence showing that VMMC is a one-time medical procedure that substantially lowers a man's lifetime risk of acquiring HIV through heterosexual exposure. The opportunity frames VMMC as one of the most effective prevention tools available, citing three randomized controlled trials showing about a 60% reduction in HIV acquisition risk, with longer-term follow-up in Uganda and Kenya indicating that the protective benefit remains durable over time and may even increase in some settings.
The announcement places this supplement within the broader global public health strategy led by WHO and UNAIDS. In 2007, WHO/UNAIDS issued guidance recognizing VMMC as an important additional intervention for countries with generalized HIV epidemics and low baseline circumcision prevalence, and then promoted a regional scale-up framework for Eastern and Southern Africa. A major regional benchmark was established: reaching 80% circumcision coverage among males aged 15 to 49 across 14 priority countries, equating to roughly 20.3 million circumcisions targeted by the end of 2016. The grant description uses modeling to emphasize why rapid scale-up matters, noting estimates that achieving 8 out of 10 adult men circumcised within five years could avert around 3.4 million new HIV infections over 15 years and potentially save about $16.5 billion in HIV care and treatment costs. It also highlights a South Africa-specific modeling implication: under that scale-up scenario, roughly one HIV infection could be prevented for every five men circumcised.
Beyond the direct protective effect for men, the opportunity stresses VMMC programs as an entry point for broader health services and prevention benefits. PEPFAR-supported VMMC programs routinely incorporate HIV testing and counseling, making circumcision service sites a practical way to reach men who may otherwise have limited contact with the health system. When clients test HIV-positive, programs are expected to refer them into HIV care and treatment, which can amplify community-level prevention because effective treatment greatly reduces onward transmission risk. The announcement also underscores that VMMC has important indirect benefits for women: as HIV prevalence declines among men due to circumcision, women are less likely to encounter HIV-positive partners. Modeling referenced in the description suggests that nearly half of the infections prevented through rapid male circumcision scale-up could occur among women. Additional potential benefits mentioned include reduced risk of certain sexually transmitted infections for women, including lower exposure to high-risk HPV strains linked to cervical cancer.
In practical implementation terms, the purpose of this specific funding opportunity announcement is not to launch brand-new recipient organizations, but to provide additional funds to existing CDC-South Africa partners to accelerate and expand service delivery. The geographic focus is clear: scale-up of VMMC in 27 high-burden districts, as well as in sub-districts where male circumcision prevalence is low, concentrating resources where unmet need and potential HIV prevention impact are greatest. The mechanism is a cooperative agreement, which typically implies substantial federal involvement in programmatic coordination, monitoring, and technical support compared with a standard grant.
Key administrative details in the source information include that it is a discretionary opportunity from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), with the activity category listed as Health and the CFDA number 93.067. The funding opportunity number is CDC RFA GH11-11500503SUPP16. The original posting date is August 18, 2016, and the original closing date is October 17, 2016, with electronic submissions due by 11:59 p.m. ET on the deadline. The award ceiling is $5,489,235, with one expected award. Eligibility is listed as "Others" with clarification referenced in an additional eligibility text field, and the overall intent is explicitly framed as a program expansion supplement for ongoing CDC South Africa partners delivering PEPFAR-supported VMMC services.
Frequently Asked Questions (FAQs)
1) What is the title of this grant opportunity?
The opportunity is titled "Program Expansion Supplement: Provision of Male Medical Circumcision (MMC) in South Africa under PEPFAR."
2) Which agency is offering this funding?
This is a U.S. Department of Health and Human Services opportunity administered by the Centers for Disease Control and Prevention (CDC).
3) What is the funding opportunity number?
The funding opportunity number is CDC RFA GH11-11500503SUPP16.
4) What is the CFDA number and activity category for this opportunity?
The CFDA number is 93.067, and the activity category is Health.
5) What type of award mechanism is being used?
The mechanism is a cooperative agreement, which generally indicates substantial federal involvement in coordination, monitoring, and technical support compared with a standard grant.
6) What is the main purpose of this supplement?
The purpose is to accelerate and expand voluntary medical male circumcision (VMMC) service delivery in South Africa as a core HIV prevention strategy under PEPFAR, using additional funds to scale up services.
7) Is this opportunity intended to fund brand-new organizations or new programs?
No. The announcement describes this as a program expansion supplement intended to provide additional funds to existing CDC-South Africa partners, rather than launching brand-new recipient organizations.
8) What specific intervention is being expanded through this funding?
The intervention is voluntary medical male circumcision (VMMC), described as a one-time medical procedure that substantially lowers a man's lifetime risk of acquiring HIV through heterosexual exposure.
9) What scientific evidence does the announcement cite for VMMC effectiveness?
The description cites three randomized controlled trials showing about a 60% reduction in HIV acquisition risk, with longer-term follow-up in Uganda and Kenya indicating the protective benefit is durable over time and may even increase in some settings.
10) How does this opportunity fit into broader global HIV prevention strategy?
The supplement is framed within the WHO and UNAIDS strategy. The announcement references 2007 WHO/UNAIDS guidance recognizing VMMC as an important additional intervention for countries with generalized HIV epidemics and low baseline circumcision prevalence, along with a regional scale-up framework for Eastern and Southern Africa.
11) What regional coverage benchmark is referenced?
A benchmark is reaching 80% circumcision coverage among males aged 15 to 49 across 14 priority countries, equating to roughly 20.3 million circumcisions targeted by the end of 2016.
12) Why does the announcement emphasize rapid scale-up of VMMC?
The grant description uses modeling to highlight that speed matters. It notes estimates that achieving 8 out of 10 adult men circumcised within five years could avert around 3.4 million new HIV infections over 15 years and potentially save about $16.5 billion in HIV care and treatment costs.
13) What modeling implication is highlighted specifically for South Africa?
The announcement highlights a South Africa-specific modeling implication that under the rapid scale-up scenario, roughly one HIV infection could be prevented for every five men circumcised.
14) Where in South Africa is this expansion focused?
The geographic focus is scale-up of VMMC in 27 high-burden districts, as well as in sub-districts where male circumcision prevalence is low, concentrating resources where unmet need and potential HIV prevention impact are greatest.
15) Does the announcement mention how VMMC sites connect to other health services?
Yes. It describes VMMC programs as an entry point for broader health services, noting that PEPFAR-supported VMMC programs routinely incorporate HIV testing and counseling.
16) What happens when a VMMC client tests HIV-positive at a service site?
The announcement states that when clients test HIV-positive, programs are expected to refer them into HIV care and treatment.
17) How does linking HIV-positive clients to treatment relate to prevention goals?
The description notes that effective treatment greatly reduces onward transmission risk, which can amplify community-level prevention when people who test positive are linked to care and treatment.
18) Does the opportunity discuss benefits for women as well as men?
Yes. It emphasizes indirect benefits for women as HIV prevalence declines among men due to circumcision, making women less likely to encounter HIV-positive partners.
19) What does the announcement say about the share of infections prevented among women?
Modeling referenced in the description suggests that nearly half of the infections prevented through rapid male circumcision scale-up could occur among women.
20) Are any additional potential health benefits mentioned beyond HIV prevention?
Yes. The opportunity mentions potential reductions in certain sexually transmitted infections for women, including lower exposure to high-risk HPV strains linked to cervical cancer.
21) What is the award ceiling and how many awards are expected?
The award ceiling is $5,489,235, and one award is expected.
22) What are the posting and closing dates listed for this announcement?
The original posting date is August 18, 2016, and the original closing date is October 17, 2016.
23) When are electronic submissions due?
Electronic submissions are due by 11:59 p.m. ET on the deadline date.
24) What kind of funding opportunity is this (mandatory vs. discretionary)?
The announcement is listed as a discretionary opportunity.
25) Who is eligible to apply based on the listing?
Eligibility is listed as "Others," with clarification referenced in an additional eligibility text field. The overall intent is explicitly framed as a program expansion supplement for ongoing CDC South Africa partners delivering PEPFAR-supported VMMC services.
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