Protein Interactions Governing Membrane Transport in Pulmonary Health and Disease (R01) | Apply Online

Opportunity Summary:

Protein Interactions Governing Membrane Transport in Pulmonary Health and Disease (R01) is a National Institutes of Health funding opportunity from the National Heart, Lung, and Blood Institute that supports investigator-initiated research focused on how membrane trafficking works in the lung and how failures in those trafficking systems contribute to disease. The central idea behind the announcement is that, now that the Human Genome Project is complete and modern molecular and cellular technologies are widely available, researchers can connect genetic and molecular findings to the underlying cellular machinery that drives many rare and common pulmonary disorders. This FOA is specifically interested in studies that map and explain the protein-protein interactions, complexes, and signaling pathways that control membrane transport processes in pulmonary cells, and in using that knowledge to point toward or build new therapeutic strategies.

The scientific scope is aimed at the biology of membrane trafficking as it relates to pulmonary health and disease, with an emphasis on identifying the interaction networks that govern transport, sorting, recycling, secretion, and other vesicle- and membrane-based movement of proteins and lipids within cells. In practical terms, the FOA is looking for projects that can delineate which proteins interact with one another, how those interactions are organized into pathways, and how disruptions in those relationships cause or worsen lung pathology. While the summary text does not list specific diseases or required models, it clearly frames the target area as pulmonary diseases tied to defects in membrane trafficking pathways, which can include disorders where mislocalization of channels, receptors, transporters, surfactant-related proteins, or immune and inflammatory mediators plays a key role. A second, equally important theme is translation: applicants are encouraged not only to describe mechanisms but also to leverage those mechanistic insights to develop novel therapeutic interventions, which can range from target identification and validation to early-stage therapeutic development approaches.

The mechanism of support is the NIH Research Project Grant (R01), meaning it is intended for substantial, hypothesis-driven projects that can stand as a coherent research program rather than a small pilot. As an R01, this opportunity is designed to support multi-year work where the applicant team proposes clear aims, a strong approach, and a realistic plan for producing impactful results in the field of lung biology and disease. Because the nature of membrane trafficking research can vary widely in cost and scale depending on the experimental systems and technologies used, the FOA notes that award size and project duration will vary across funded applications. It also states that the total number of awards and total dollars will depend on the number of applications received as well as their scientific quality, budgets, and proposed timelines, rather than setting a fixed number of awards.

Key administrative details include the funding opportunity number PA 07 137 and the CFDA number 93.838 (Lung Diseases Research). The opportunity is categorized as discretionary and uses the grant funding instrument. It was originally posted on December 12, 2006, with multiple receipt dates indicated in the full announcement, meaning applicants would need to consult the NIH posting for the specific submission cycles that applied during the active period. The archive date is April 5, 2009, which indicates the announcement is no longer active as written, but it remains useful as a description of NHLBI priorities at the time and as a model for how NIH frames this research area.

Eligibility is broad across many U.S.-based organization types, including public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, with the noted exception language), state and local governments, tribal governments and tribal organizations, public housing authorities/Indian housing authorities, special district governments, independent school districts, and for-profit organizations (including small businesses and other for-profits). The listing also indicates that eligible federal agencies may apply and that faith-based or community-based organizations are eligible. A major restriction is that foreign institutions are not eligible to apply under this FOA, which is an important boundary condition for teams considering international lead applicants (though collaborators may be possible depending on NIH policy and the specifics of the application). The FOA also specifies that there is no cost-sharing or matching requirement, consistent with typical NIH research project grants.

The full announcement and application instructions were provided through the NIH Grants Guide link (http://grants.nih.gov/grants/guide/pa-files/PA-07-137.html). For technical issues accessing the announcement, the contact is the NIH Office of Extramural Research webmaster at FBOWebmaster@od.nih.gov. Overall, this opportunity is best understood as NHLBI support for rigorous, mechanistic membrane trafficking research in lung biology, paired with an explicit encouragement to move from pathway maps and interaction networks toward therapeutic concepts that could eventually improve diagnosis, prevention, or treatment of pulmonary disease.

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