Opportunity Information: Apply for W81XWH 14 DMRDP CRMRP RTRA
Apply for W81XWH 14 DMRDP CRMRP RTRA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "Reconstructive Transplantation Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Jul 30, 2014 and posted on Jul 30, 2014.
- Applicants must submit their applications by Oct 29, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $13,300,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 7 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The Reconstructive Transplantation Research Award (RTR Award) was a Fiscal Year 2014 funding opportunity under the Department of Defense Clinical and Rehabilitative Medicine Research Program (CRMRP), administered by the U.S. Army Medical Research Acquisition Activity (USAMRAA) for the Defense Health Program. Its central purpose was to fund innovative, high-impact research that could meaningfully improve function, wellness, and overall quality of life for injured military Service Members and Veterans, along with their caregivers and families, with potential spillover benefits for the broader public.
A major focus of the opportunity was reconstructive transplantation, specifically vascularized composite allotransplantation (VCA), also known as composite tissue allotransplantation (CTA). This refers to transplanting multiple tissue types together as one functional unit, such as transplantation of a hand or face from a deceased donor to a recipient with severe injury. Because VCA involves complex combinations of tissues (for example, skin, muscle, bone, and nerves), the program emphasized research that could push the field forward in ways that address unmet needs and underexplored problems, particularly those relevant to military trauma and rehabilitation outcomes.
While the RTR Award was positioned to support groundbreaking ideas, the solicitation made clear that proposals still needed a strong scientific foundation and a clear line of sight to military relevance and real-world utility. Beyond novelty, the program placed special emphasis on research that would accelerate translation into clinical use, including projects designed to rapidly move results into practice. In practical terms, the announcement highlighted two especially favored directions: first, projects aimed at modifying, restructuring, or otherwise improving clinical practice guidelines; and second, projects that help standardize clinical processes and protocols, including adaptation of methods and operational approaches already used in solid organ transplantation. The intent was to reduce variability, improve consistency and safety, and help the field mature toward broader, more reliable clinical implementation.
Collaboration was strongly encouraged. The opportunity explicitly welcomed applications from investigators within the military Services and promoted multidisciplinary partnerships across academia, industry, the military, the Department of Veterans Affairs, and other federal agencies. The mechanism was also meant to be accessible to both new and established investigators, reflecting a desire to draw in a wide range of scientific and clinical expertise capable of producing major advances in reconstructive transplantation research and its clinical adoption.
From an administrative and funding standpoint, this was a discretionary opportunity with awards issued as grants or cooperative agreements, under CFDA 12.420 (Military Medical Research and Development). The program anticipated making about 7 awards, with an estimated total funding level of $13.3 million. There was no cost-sharing or matching requirement, and eligibility was described as unrestricted (open broadly to entity types, subject to any clarifications in the full announcement). The funding opportunity number was W81XWH-14-DMRDP-CRMRP-RTRA. It was posted on July 30, 2014, and the application deadline was October 29, 2014 (archived November 28, 2014). For support, the announcement directed applicants to the CDMRP Help Desk at 301-682-5507 or help@cdmrp.org.
Reconstructive Transplantation Research Award (RTR Award) FAQs
What is the Reconstructive Transplantation Research Award (RTR Award)?
The Reconstructive Transplantation Research Award (RTR Award) was a Fiscal Year 2014 funding opportunity under the Department of Defense (DoD) Clinical and Rehabilitative Medicine Research Program (CRMRP). It was administered by the U.S. Army Medical Research Acquisition Activity (USAMRAA) for the Defense Health Program.
What was the main purpose of the RTR Award?
The central purpose was to fund innovative, high-impact research intended to meaningfully improve function, wellness, and overall quality of life for injured military Service Members and Veterans, as well as their caregivers and families, with potential benefits for the broader public.
What research area did this opportunity focus on?
A major focus was reconstructive transplantation, specifically vascularized composite allotransplantation (VCA), also known as composite tissue allotransplantation (CTA).
What is vascularized composite allotransplantation (VCA) or composite tissue allotransplantation (CTA)?
VCA (also called CTA) refers to transplanting multiple tissue types together as one functional unit. Examples include transplantation of a hand or face from a deceased donor to a recipient with severe injury. These transplants can involve complex combinations of tissues such as skin, muscle, bone, and nerves.
Why was VCA/CTA emphasized in this award?
Because VCA involves complex, multi-tissue transplants and significant clinical and operational challenges, the program emphasized research that could push the field forward by addressing unmet needs and underexplored problems, especially those relevant to military trauma and rehabilitation outcomes.
Did proposals need to be innovative, or could they be incremental?
The opportunity was positioned to support groundbreaking ideas, but proposals still needed a strong scientific foundation and a clear connection to military relevance and real-world utility.
What did the RTR Award emphasize beyond novelty?
Beyond novelty, the solicitation placed special emphasis on research that would accelerate translation into clinical use, including projects designed to rapidly move results into practice.
What types of projects were especially favored?
The announcement highlighted two especially favored directions: (1) projects aimed at modifying, restructuring, or otherwise improving clinical practice guidelines; and (2) projects that help standardize clinical processes and protocols, including adapting methods and operational approaches already used in solid organ transplantation.
What was the intent behind standardizing clinical processes and protocols?
The intent was to reduce variability, improve consistency and safety, and help reconstructive transplantation mature toward broader, more reliable clinical implementation.
Was collaboration required?
Collaboration was strongly encouraged. The opportunity explicitly welcomed applications from investigators within the military Services and promoted multidisciplinary partnerships across academia, industry, the military, the Department of Veterans Affairs, and other federal agencies.
Could new investigators apply, or was it intended only for established teams?
The mechanism was meant to be accessible to both new and established investigators, reflecting an interest in drawing a wide range of scientific and clinical expertise into reconstructive transplantation research and its clinical adoption.
Who administered the RTR Award?
The opportunity was administered by the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the DoD Clinical and Rehabilitative Medicine Research Program (CRMRP).
What type of funding mechanism was used?
Awards were issued as grants or cooperative agreements under a discretionary funding opportunity.
What CFDA number applied to this opportunity?
The opportunity was listed under CFDA 12.420 (Military Medical Research and Development).
How many awards were anticipated, and what was the estimated total funding?
The program anticipated making about 7 awards, with an estimated total funding level of $13.3 million.
Was cost sharing or a matching contribution required?
No. There was no cost-sharing or matching requirement described for this opportunity.
Who was eligible to apply?
Eligibility was described as unrestricted, meaning it was broadly open to entity types, subject to any clarifications in the full announcement.
What was the funding opportunity number?
The funding opportunity number was W81XWH-14-DMRDP-CRMRP-RTRA.
When was the opportunity posted?
It was posted on July 30, 2014.
What was the application deadline?
The application deadline was October 29, 2014.
Is this opportunity still open?
No. The listing indicates it was archived on November 28, 2014.
Where could applicants get help or support while applying?
Applicants were directed to the CDMRP Help Desk at 301-682-5507 or help@cdmrp.org.
Who were the intended beneficiaries of research funded by this award?
The opportunity emphasized benefits for injured military Service Members and Veterans, along with their caregivers and families, with potential spillover benefits for the broader public.
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