Opportunity Information: Apply for RFA HS 10 001
Apply for RFA HS 10 001
- The Agency for Health Care Research and Quality in the health recovery act sector is offering a public funding opportunity titled "Recovery Act 2009 Limited Competition Expansion of Research Capability to Study Comparative Effectiveness in Complex Patients (R24)" and is now available to receive applicants.
- This funding opportunity was created on Dec 22, 2009 and posted on Dec 22, 2009.
- Applicants must submit their applications by Jan 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $12,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 12 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education County governments City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Native American tribal governments (Federally recognized) State governments.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Faith based or Community based Organizations Indian/Native American Tribal Governments (Other than Federally Recognized).
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Opportunity Summary:
The Recovery Act 2009 Limited Competition Expansion of Research Capability to Study Comparative Effectiveness in Complex Patients (R24) was a discretionary grant opportunity from the Agency for Healthcare Research and Quality (AHRQ) designed to strengthen the nation s research infrastructure for studying people with multiple chronic illnesses, described in the announcement as "complex patients." Rather than primarily funding a single comparative effectiveness study, the program focused on building the underlying capacity needed to do better, more reliable epidemiologic and comparative effectiveness research in this population over time. The intent was to help create the kinds of partnerships, data resources, and methodological tools that make it possible to generate evidence that a future health system can use to improve care for diverse patients who often have overlapping conditions, competing treatment priorities, and higher risks of fragmented care.
The core purpose of the FOA was infrastructure development. Applicants were expected to propose efforts that would build or enhance multi organization partnerships, develop or expand datasets, and advance methods specifically suited to comparative effectiveness research in complex patients. This emphasis reflects a practical challenge in health services research: standard study designs and single disease datasets often do not capture the real world complexity of patients with multiple chronic illnesses, where treatments can interact, outcomes may be multidimensional, and usual eligibility criteria can exclude precisely the people clinicians most struggle to treat. By investing in research infrastructure, AHRQ aimed to raise both the volume and the quality of future studies, making results more applicable to real care settings and more useful for decision makers.
The funding was supported by the American Recovery and Reinvestment Act of 2009 (ARRA), meaning it was part of the one time federal push to accelerate economic activity while also making strategic investments in public priorities, including health research. In this case, ARRA funds were used to quickly expand national capacity for comparative effectiveness research and to help ensure that evidence development included populations with multiple chronic conditions, not only patients with single, neatly defined diagnoses.
The mechanism of support was the AHRQ Research Infrastructure Development grant (R24). R24 awards generally support resources, coordination structures, shared tools, and other enabling capabilities that can be used by multiple projects or investigators, rather than supporting a single narrow experiment. Under this FOA, the R24 mechanism signaled that awardees were expected to leave behind durable infrastructure such as improved data linkages, governance structures for collaboration, standardized approaches to measurement, validated analytic methods, or other reusable research assets that would continue to support comparative effectiveness work beyond the grant period.
Key administrative details show a relatively focused, time limited competition. The funding opportunity number was RFA HS 10 001, with a posted and created date of December 22, 2009, and an original and current closing date of January 20, 2010. The opportunity was archived on February 20, 2010. AHRQ anticipated making about 12 awards, with an estimated total funding level of 12,000,000 dollars. Individual awards had a ceiling of 500,000 dollars. There was no cost sharing or matching requirement, which lowered barriers for participation and made it easier for public agencies, academic institutions, and community based organizations to apply without needing to secure additional non federal dollars.
Eligibility was broad and included public and state controlled institutions of higher education, private institutions of higher education, state governments, county governments, and city or township governments. It also included Native American tribal governments (federally recognized) and other Native American tribal organizations, as well as faith based and community based organizations, and eligible federal agencies. This wide eligibility aligns with the infrastructure focus: building comparative effectiveness capacity for complex patients often requires cross sector partnerships among universities, health systems, public health and social service agencies, and community organizations that can contribute data, recruitment pathways, or implementation contexts.
In practical terms, a competitive application under this FOA would likely have centered on creating or upgrading shared research platforms that make complex patient research feasible at scale. That could include developing datasets that better capture multimorbidity patterns, linking clinical and administrative data sources, improving measurement of outcomes that matter to complex patients, establishing common data elements, strengthening data governance and privacy protections for multi site work, or developing analytic methods that handle confounding, treatment interactions, and heterogeneity in patient needs. The overall goal was to produce research ready infrastructure that raises the rigor and relevance of comparative effectiveness findings for people with multiple chronic illnesses, helping clinicians, health systems, and policymakers make better informed decisions.
The sponsoring agency was AHRQ, and the official announcement was hosted through the NIH Office of Extramural Research grants guide. The Additional Information Link provided in the notice was http://grants.nih.gov/grants/guide/rfa files/RFA HS 10 001.html, and the listed contact for access or linking issues was the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the Recovery Act 2009 Limited Competition Expansion of Research Capability to Study Comparative Effectiveness in Complex Patients (R24)?
It was a discretionary grant opportunity from the Agency for Healthcare Research and Quality (AHRQ) aimed at strengthening the nation's research infrastructure for studying comparative effectiveness in people with multiple chronic illnesses (called "complex patients" in the announcement).
What does AHRQ mean by "complex patients" in this opportunity?
"Complex patients" refers to people with multiple chronic illnesses, often involving overlapping conditions, competing treatment priorities, and elevated risk of fragmented care.
What was the main purpose of this funding opportunity?
The core purpose was infrastructure development. The opportunity focused on building the capacity needed to conduct stronger, more reliable epidemiologic and comparative effectiveness research in complex patients over time, rather than primarily funding a single comparative effectiveness study.
Was this funding meant to support a single research study?
No. The emphasis was on creating or improving underlying research infrastructure (partnerships, data resources, and methods) that would enable multiple future comparative effectiveness studies in complex patients.
What kinds of activities were applicants expected to propose?
Applicants were expected to propose efforts that build or enhance multi-organization partnerships, develop or expand datasets, and advance methods specifically suited to comparative effectiveness research in complex patients.
Why did AHRQ focus on infrastructure for complex patient research?
The opportunity highlights a practical challenge in health services research: standard study designs and single-disease datasets often do not reflect real-world complexity. Treatments can interact, outcomes may be multidimensional, and typical eligibility criteria may exclude the very patients clinicians most struggle to treat. Infrastructure investment was intended to improve the volume and quality of future research and make findings more applicable to real care settings.
What is the funding mechanism used for this program?
The mechanism was the AHRQ Research Infrastructure Development grant (R24). R24 awards generally support shared resources, coordination structures, shared tools, and enabling capabilities that can be used by multiple investigators or projects.
What types of infrastructure were awardees expected to leave behind?
The FOA indicated an expectation of durable, reusable infrastructure such as improved data linkages, governance structures for collaboration, standardized approaches to measurement, validated analytic methods, or other reusable research assets that would continue supporting comparative effectiveness work beyond the grant period.
How was this opportunity funded?
Funding was supported by the American Recovery and Reinvestment Act of 2009 (ARRA). The program was part of a one-time federal push that included strategic investments in health research, including expanding national capacity for comparative effectiveness research.
What is the funding opportunity number for this FOA?
The funding opportunity number was RFA HS 10 001.
When was the opportunity posted and when did it close?
The posted/created date was December 22, 2009. The original and current closing date was January 20, 2010.
Is this funding opportunity still open?
No. The opportunity was archived on February 20, 2010.
How many awards did AHRQ anticipate making?
AHRQ anticipated making about 12 awards.
What was the estimated total funding available?
The estimated total funding level was 12,000,000 dollars.
What was the maximum award amount per grant?
Individual awards had a ceiling of 500,000 dollars.
Was cost sharing or matching required?
No. There was no cost sharing or matching requirement.
Who was eligible to apply?
Eligibility was broad and included:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- State governments
- County governments
- City or township governments
- Native American tribal governments (federally recognized)
- Other Native American tribal organizations
- Faith-based organizations
- Community-based organizations
- Eligible federal agencies
Why was eligibility so broad?
The infrastructure focus often requires cross-sector partnerships among universities, health systems, public health and social service agencies, and community organizations that can contribute data, recruitment pathways, or implementation contexts.
What are examples of competitive application elements under this FOA?
Based on the description, competitive applications would likely have centered on creating or upgrading shared research platforms that make complex-patient comparative effectiveness research feasible at scale. Examples mentioned include developing datasets that capture multimorbidity patterns, linking clinical and administrative data sources, improving measurement of outcomes important to complex patients, establishing common data elements, strengthening data governance and privacy protections for multi-site work, and developing analytic methods addressing confounding, treatment interactions, and patient heterogeneity.
What was the overall long-term goal of the program?
The overall goal was to produce research-ready infrastructure that improves the rigor and relevance of comparative effectiveness findings for people with multiple chronic illnesses, helping clinicians, health systems, and policymakers make better-informed decisions.
Which agency sponsored this opportunity?
The sponsoring agency was the Agency for Healthcare Research and Quality (AHRQ).
Where was the official announcement hosted?
The official announcement was hosted through the NIH Office of Extramural Research grants guide.
Where can I find the additional information link referenced in the notice?
The additional information link provided was: http://grants.nih.gov/grants/guide/rfa files/RFA HS 10 001.html
Who was listed as the contact for access or linking issues?
The listed contact for access or linking issues was the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV.
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| Funding Opportunity |
|---|
| ARRAOS Recovery Act Limited Competition Behavioral Economics for Nudging the Implementation of Comparative Effectiveness Research Clinical Trials (RC4) Apply for RFA OD 10 001 Funding Number: RFA OD 10 001 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
| ARRAOS Recovery Act Limited Competition Behavioral Economics for Nudging the Implementation of Comparative Effectiveness Research Pilot Research (RC4) Apply for RFA OD 10 002 Funding Number: RFA OD 10 002 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $500,000 |
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| Recovery Act Limited Competition NIH Directors Opportunity for Research in Five Thematic Areas (RC4) Apply for RFA OD 10 005 Funding Number: RFA OD 10 005 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
| Recovery Act Limited Competition Methodology Development in Comparative Effectiveness Research (RC4) Apply for RFA OD 10 009 Funding Number: RFA OD 10 009 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $500,000 |
| Recovery Act Limited Competition Research On Biosamples From Selected Diabetes Clinical Studies (RC4) Apply for RFA OD 10 010 Funding Number: RFA OD 10 010 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
| ARRA OS Recovery Act 2009 Accelerating Adoption of Comparative Effectiveness Research Results by Providers and Patients (R18) Apply for RFA AE 10 001 Funding Number: RFA AE 10 001 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
| Recovery Act Limited Competition Institutional Comparative Effectiveness Research Mentored Career Development Award (KM1) Apply for RFA OD 10 011 Funding Number: RFA OD 10 011 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
| ARRA OS Recovery Act 2009 Limited Competition Enhanced Registries for Quality Improvement and Comparative Effectiveness Research (R01) Apply for RFA HS 10 020 Funding Number: RFA HS 10 020 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: $4,000,000 |
| Recovery Act Limited Competition Framework Programs for Global Health Signature Innovations Initiative (R24) Apply for RFA OD 10 007 Funding Number: RFA OD 10 007 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $250,000 |
| Recovery Act Limited Competition Program to Enhance NIH supported Global Health Research Involving Human Subjects (S07) Apply for RFA OD 10 006 Funding Number: RFA OD 10 006 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $50,000 |
| ARRA OS Recovery Act 2009 Limited Competition Accelerating Implementation of Comparative Effectiveness Findings on Clinical and Delivery System Interventions by Leveraging AHRQ Networks (R18) Apply for RFA HS 10 014 Funding Number: RFA HS 10 014 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: $16,660,000 |
| ARRA OS Recovery Act 2009 Limited Competition Comparative Effectiveness Delivery System Evaluation Grants (R01) Apply for RFA HS 10 012 Funding Number: RFA HS 10 012 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: $500,000 |
| ARRA OS Recovery Act 2009 Limited Competition Comparative Effectiveness Delivery System Demonstration Grants (R18) Apply for RFA HS 10 013 Funding Number: RFA HS 10 013 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: Case Dependent |
| ARRA OS Recovery Act 2009 Limited Competition Enhanced State Data for Analysis and Tracking of Comparative Effectiveness Impact Improved Clinical Content and Race Ethnicity Data (R01) Apply for RFA HS 10 010 Funding Number: RFA HS 10 010 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: Case Dependent |
| Recovery Act Limited Competition The NIH Directors ARRA Funded Pathfinder Award to Promote Diversity in the Scientific Workforce (DP4) Apply for RFA OD 10 013 Funding Number: RFA OD 10 013 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $2,000,000 |
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