Opportunity Information: Apply for RFA OD 10 009
Apply for RFA OD 10 009
- The National Institutes of Health in the health recovery act sector is offering a public funding opportunity titled "Recovery Act Limited Competition Methodology Development in Comparative Effectiveness Research (RC4)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.701 Trans NIH Recovery Act Research Support.
- This funding opportunity was created on Jan 20, 2010 and posted on Dec 28, 2009.
- Applicants must submit their applications by Feb 26, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $10,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments Native American tribal governments (Federally recognized) Private institutions of higher education County governments Independent school districts Special district governments Public housing authorities/Indian housing authorities Small businesses City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession The following organizations/institutions are eligible to apply. Consistent with the purposes of the Recovery Act (in particular, to preserve and create jobs and promote economic recovery in the United States, and to provide investments needed to increase economic efficiency by spurring technological advances in science and health), applicants must be a domestic (United States) institution/organization. The United States institution/organization must be located in the 50 states, territories and possessions of the U.S., Commonwealth of Puerto Rico, Trust Territory of the Pacific Islands, or District of Columbia. NIH encourages applications from all interested organizations/institutions, including those from Institutional Development Award (IDeA) states and Academic Research Enhancement Award (AREA) eligible institutions. Foreign organizations/institutions are not permitted as the applicant organization.
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Opportunity Summary:
The Recovery Act Limited Competition Methodology Development in Comparative Effectiveness Research (RC4) opportunity (Funding Opportunity Number RFA-OD-10-009) was a National Institutes of Health grant program funded through the American Recovery and Reinvestment Act of 2009 (ARRA), with support involving both NIH and the Agency for Healthcare Research and Quality (AHRQ). Its central goal was to strengthen the methodological backbone of comparative effectiveness research (CER) by funding projects that enhance, develop, or rigorously evaluate research methods so CER studies can produce faster, more reliable, and more credible evidence for real-world decision-making.
This FOA focused on the fact that CER relies on many different study approaches, such as technology assessments, meta-analyses, systematic reviews, observational studies, and randomized experimental trials, and that each of these approaches has well-known limitations that can weaken conclusions or slow down how quickly results can be translated into practice. The program specifically encouraged work aimed at identifying, measuring, reducing, or correcting key sources of error and uncertainty. Examples highlighted in the announcement include confounding bias in observational studies (where differences between comparison groups can distort results) and selection bias in randomized trials (where enrollment or retention patterns can make trial participants differ from the broader patient population). Overall, the intent was to produce better tools, designs, and analytic strategies that would make CER findings more trustworthy for patients, clinicians, health systems, payers, and policymakers.
For the purposes of this grant, CER was defined in line with the Federal Coordinating Council definition: research that conducts and synthesizes comparisons of the benefits and harms of different interventions and strategies to prevent, diagnose, treat, and monitor health conditions in real-world settings. The emphasis on "real-world" use meant the methodological work supported by this FOA was expected to improve the practical value of evidence, helping stakeholders understand not only what works on average, but what works best for which patients under specific circumstances. A key theme was improving evidence-based decision-making by producing and disseminating information that better matches the expressed needs of end users of research.
Administratively, this was a discretionary grant program in the health domain under the Trans-NIH Recovery Act Research Support CFDA number 93.701. The opportunity was posted on December 28, 2009, with an original and current closing date of February 26, 2010, and an archive date of March 29, 2010. The estimated total funding amount was $10,000,000, with an award ceiling of $500,000 per award, and there was no cost-sharing or matching requirement.
Eligibility was broad but restricted to domestic applicants, consistent with ARRA goals of preserving and creating U.S. jobs and promoting economic recovery. Eligible applicants included state and local governments (including counties, cities or townships, special districts, and independent school districts), tribal governments and tribal organizations, public housing authorities, public and private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3)), and for-profit organizations (including small businesses and other for-profits). The FOA also explicitly included a range of institution types and community-based entities such as faith-based or community-based organizations, HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities, regional organizations, U.S. territories or possessions, and eligible federal agencies. Foreign organizations were not permitted as the applicant organization; applicants had to be located in the 50 states, U.S. territories and possessions, Puerto Rico, the Trust Territory of the Pacific Islands, or the District of Columbia. NIH also encouraged applications from IDeA states and AREA-eligible institutions to broaden participation and research capacity.
In practical terms, this grant opportunity was designed to accelerate improvements in the methods that CER depends on, so that future comparative studies and evidence syntheses could better handle bias, improve validity, and deliver results that clinicians and patients can confidently use. The full announcement was made available through NIH, with contact support through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
Frequently Asked Questions (FAQs)
What is the Recovery Act Limited Competition Methodology Development in Comparative Effectiveness Research (RC4) opportunity?
It was a National Institutes of Health (NIH) grant opportunity funded through the American Recovery and Reinvestment Act of 2009 (ARRA). The program supported projects focused on methodology development for comparative effectiveness research (CER), under Funding Opportunity Number (FON) RFA-OD-10-009.
Which agencies supported this funding opportunity?
The opportunity involved NIH and also included support involving the Agency for Healthcare Research and Quality (AHRQ).
What was the central goal of this FOA?
The central goal was to strengthen the methodological backbone of CER by funding projects that enhance, develop, or rigorously evaluate research methods. The intent was to help CER produce faster, more reliable, and more credible evidence for real-world decision-making.
What kinds of research methods and study approaches were within scope?
The FOA highlighted that CER relies on multiple approaches, including technology assessments, meta-analyses, systematic reviews, observational studies, and randomized experimental trials. Methodology projects relevant to these approaches were within scope.
What methodological problems was the program trying to address?
The program encouraged work aimed at identifying, measuring, reducing, or correcting key sources of error and uncertainty that can weaken conclusions or slow translation into practice.
What examples of bias or uncertainty were specifically mentioned?
Examples included confounding bias in observational studies (differences between comparison groups that can distort results) and selection bias in randomized trials (enrollment or retention patterns that make trial participants differ from the broader patient population).
How did this FOA define comparative effectiveness research (CER)?
CER was defined consistent with the Federal Coordinating Council definition: research that conducts and synthesizes comparisons of the benefits and harms of different interventions and strategies to prevent, diagnose, treat, and monitor health conditions in real-world settings.
What does "real-world settings" mean in the context of this program?
The emphasis on real-world use meant the funded methodological work was expected to improve the practical value of evidence, including helping stakeholders understand what works on average and what works best for which patients under specific circumstances.
Who were the intended end users of improved CER methods and evidence?
The FOA described end users broadly, including patients, clinicians, health systems, payers, and policymakers.
What was the focus on decision-making and dissemination?
A key theme was improving evidence-based decision-making by producing and disseminating information that better matches the expressed needs of end users of research.
What CFDA number applied to this program?
The program was listed under the Trans-NIH Recovery Act Research Support CFDA number 93.701.
Was this a discretionary grant program?
Yes. Administratively, it was described as a discretionary grant program in the health domain.
What was the total estimated funding amount?
The estimated total funding amount was $10,000,000.
What was the maximum award amount (award ceiling)?
The award ceiling was $500,000 per award.
Was cost-sharing or matching required?
No. The FOA stated there was no cost-sharing or matching requirement.
When was the opportunity posted?
The opportunity was posted on December 28, 2009.
What were the closing date and archive date?
The original and current closing date was February 26, 2010. The archive date was March 29, 2010.
Who was eligible to apply?
Eligibility was broad but restricted to domestic applicants. Eligible applicants included state and local governments (including counties, cities or townships, special districts, and independent school districts), tribal governments and tribal organizations, public housing authorities, public and private institutions of higher education, nonprofits (501(c)(3) and non-501(c)(3)), and for-profit organizations (including small businesses and other for-profits).
Were community-based and faith-based organizations included?
Yes. The FOA explicitly included community-based entities, including faith-based or community-based organizations.
Were specific institution types called out as eligible?
Yes. The FOA explicitly mentioned HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities, among others.
Were U.S. territories and possessions included in the eligible applicant locations?
Yes. Applicants could be located in the 50 states, U.S. territories and possessions, Puerto Rico, the Trust Territory of the Pacific Islands, or the District of Columbia.
Were foreign organizations allowed to apply?
No. Foreign organizations were not permitted as the applicant organization; applicants had to be domestic and located in the allowed U.S. jurisdictions listed in the announcement.
Were eligible federal agencies allowed to apply?
Yes. The FOA listed eligible federal agencies among eligible applicant types.
Why was eligibility restricted to domestic applicants?
The restriction aligned with ARRA goals of preserving and creating U.S. jobs and promoting economic recovery.
Did NIH encourage applications from any specific groups or regions?
Yes. NIH encouraged applications from IDeA states and AREA-eligible institutions to broaden participation and research capacity.
What was the practical intent or expected impact of funding these projects?
The intent was to accelerate improvements in the methods that CER depends on, so future comparative studies and evidence syntheses could better handle bias, improve validity, and deliver results that clinicians and patients can confidently use.
Where could applicants find the full announcement or get help with access and linking issues?
The full announcement was made available through NIH, and contact support for access or linking issues was provided through the NIH Office of Extramural Research (OER) webmaster.
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