Reissue PHS 2013 02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR R41/R42) | Apply Online

Opportunity Summary:

The NIH funding opportunity PA 13 235 is a reissued omnibus solicitation for the Small Business Technology Transfer (STTR) program, using the parent grant mechanisms R41 (Phase I) and R42 (Phase II). Its basic purpose is to fund early-stage, high-impact research and development projects led by eligible U.S. small business concerns (SBCs) working in formal collaboration with a nonprofit research institution. In practical terms, it is designed for small companies that have a promising scientific or technological idea and need federal support to prove feasibility, generate key prototype or proof-of-concept data, and then continue into more advanced development steps that align with NIH health-related missions. The FOA points applicants to NIH SBIR/STTR program descriptions and topic areas, signaling that proposed projects should fit within the research priorities of specific NIH Institutes and Centers.

A central feature of STTR, and a reason many companies pursue it, is the required partnership structure: the small business must meaningfully collaborate with a U.S. nonprofit research institution such as a university, medical center, or independent research institute. The small business is the applicant organization and the prime awardee, but the academic or nonprofit partner performs a substantial portion of the R and D effort. This arrangement is intended to accelerate technology transfer by connecting commercialization-focused small businesses with the specialized scientific expertise, facilities, and talent often found in research institutions. While the FOA text provided here does not list the detailed work-share rules, the STTR program generally expects clearly defined roles, a credible plan for coordination, and a well-justified allocation of research tasks and budget between the company and partner institution.

The scope of eligible research is broad because NIH itself is broad, and the listing of CFDA numbers shows just how many mission areas are included. The opportunity spans environmental health, oral health, genomics, communication disorders, complementary and integrative health, sleep, mental health, alcohol and substance use research, technology development to improve human health, minority health and health disparities, translational science and research infrastructure, nursing research, and an extensive set of cancer and organ-system-related research areas (cardiovascular, lung, blood, arthritis and skin, diabetes and digestive and kidney diseases, neurosciences, allergy and infectious diseases, microbiology, child health, aging, and vision). It also includes medical library assistance, reflecting NIH interests in information resources and knowledge dissemination. The practical takeaway is that projects can range from diagnostics, therapeutics, devices, digital health tools, and research platforms to enabling technologies and other innovations, as long as they squarely fit the mission of one or more participating NIH awarding components and are responsive to the topics referenced in the related NIH SBIR/STTR topics document.

This is a discretionary grant program, meaning awards are made competitively based on peer review and programmatic priorities rather than by formula. The funding instrument is a grant, not a contract, so applicants typically propose their own aims and approach within the NIH mission and topic boundaries. The parent R41/R42 structure signals the standard two-phase pathway: Phase I (R41) supports feasibility and early proof-of-concept, while Phase II (R42) supports further development, validation, and steps that move the technology closer to commercialization or broader deployment. The word "parent" is important because it indicates an omnibus solicitation that accepts investigator-initiated ideas across many topics, rather than a narrowly targeted single-topic call, though applicants are still expected to align with NIH-published topic areas and the interests of the relevant Institute or Center.

Eligibility is limited to small businesses, and the announcement is explicit about domestic requirements. Non-U.S. entities (foreign institutions) cannot apply, and non-U.S. components of U.S. organizations also cannot apply. At the same time, it notes that "foreign components" as defined by NIH policy may be allowed in some cases, which usually means a limited, well-justified portion of the work could occur outside the U.S. when there is a strong scientific reason and it is permitted under NIH rules. The FOA also states there is no cost sharing or matching requirement, which matters for small companies that may not have cash on hand to meet a mandatory match.

Key dates in the provided record show it was posted and created on May 30, 2013, with an original and current closing date of January 7, 2014, and an archive date of February 7, 2014. That timeline indicates the solicitation is historical and was active during that window, but the structure and purpose reflect the NIH parent STTR approach used across multiple cycles. Applicants interested in current opportunities would typically look for the latest parent STTR R41/R42 FOA numbers and active due dates, because NIH periodically reissues these omnibus solicitations with updated policies, forms, and instructions.

For applicants, the most important strategic point is that NIH is looking for small businesses that can credibly move biomedical and behavioral innovations toward real-world impact. A competitive STTR application under this parent FOA would usually need a clear technical rationale, a strong and realistic work plan, evidence that the team can execute, and a commercialization-oriented strategy that explains the intended product, users, market need, and pathway to adoption or regulatory clearance when relevant. Just as importantly, it needs a well-structured collaboration with the research institution partner, with responsibilities that make sense for each side and a plan that shows how the partnership will accelerate development rather than merely outsourcing work.

Administrative and access information is also provided. The official announcement page is hosted by NIH at http://grants.nih.gov/grants/guide/pa-files/PA-13-235.html, and NIH lists the Office of Extramural Research (OER) webmaster contact for technical issues accessing or linking to the FOA (FBOWebmaster@OD.NIH.GOV). That contact is specifically for access problems rather than scientific questions, which are typically handled through NIH program officers associated with the relevant Institute or Center and topic area.

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Previous opportunity: Reissue PHS 2013 02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR R43/R44)

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