Opportunity Information: Apply for PA 12 211
Apply for PA 12 211
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Renal Function and Chronic Kidney Disease in Aging (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Jun 13, 2012 and posted on Jun 13, 2012.
- Applicants must submit their applications by Sep 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Special district governments Independent school districts Private institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses City or township governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Renal Function and Chronic Kidney Disease in Aging (R01) funding opportunity (PA 12-211) is an NIH research grant announcement led by the National Institute on Aging (NIA) in partnership with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It supports investigator-initiated R01 projects that deepen scientific understanding of chronic kidney disease (CKD) specifically as it relates to aging and older adults. The overall goal is to strengthen the evidence base behind how CKD develops, progresses, and affects health in later life, and to translate that knowledge into clearer, evidence-based guidance for diagnosing, preventing, and treating CKD in older people.
The FOA encourages a broad range of research approaches, spanning basic, clinical, and translational science. Proposed projects are expected to align with one or more of four main scientific themes. First, it invites basic research that examines the biology and pathophysiology of CKD in animal models, which can include mechanistic studies on age-related changes in renal structure and function, pathways that accelerate kidney injury with age, and biological processes that may be targetable for prevention or therapy. Second, it supports research on the etiology and pathophysiology of CKD in older adults, focusing on why CKD arises or worsens in later life and how aging physiology interacts with common comorbidities and exposures. Third, it calls for epidemiology and risk-factor studies that clarify how CKD risk changes with advancing age, identify predictors of incident CKD or progression in older populations, and improve understanding of population patterns and disparities. Fourth, it encourages work on diagnosis, medical management, and clinical outcomes in older adults with CKD, including studies that refine diagnostic strategies, evaluate management approaches in real-world aging populations, and link care decisions to outcomes that matter in older age.
A central emphasis throughout the announcement is on CKD consequences in aging, meaning applicants are encouraged to address not only kidney-centered outcomes but also the broader health impacts of CKD in older persons. The FOA is oriented toward research that can ultimately improve clinical decision-making for this age group, where CKD often intersects with multimorbidity, functional limitations, medication complexity, and heterogeneous risk profiles. In practical terms, this can include developing better evidence for how to interpret kidney function measures in older adults, how to balance benefits and harms of interventions, and how CKD influences downstream outcomes over time.
Administratively, this is a discretionary grant opportunity using the NIH R01 funding mechanism, and it does not require cost sharing or matching. It was originally posted on June 13, 2012, with a closing date of September 7, 2015, and it was archived on October 8, 2015. While archived opportunities are no longer open for new submissions under that specific announcement, the description is still useful as a statement of program priorities and may have been succeeded by related or reissued NIH notices or FOAs in the same topic area.
Eligibility is broad and includes many types of domestic and international applicants. Eligible U.S. applicants span state, county, city/township, and special district governments; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; and for-profit organizations (other than small businesses). The eligibility language also explicitly includes a range of mission-focused institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), tribal governments (federally recognized and other than federally recognized), regional organizations, U.S. territories or possessions, and faith-based or community-based organizations. Foreign institutions are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy.
The opportunity is associated with NIH assistance listings (CFDA) 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) and 93.866 (Aging Research), reflecting the joint NIDDK and NIA sponsorship. The full archived announcement was made available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-12-211.html, and the NIH Office of Extramural Research (OER) provided a webmaster contact for access or linking issues (FBOWebmaster@OD.NIH.GOV).
FAQs: Renal Function and Chronic Kidney Disease in Aging (R01) - PA-12-211
What is the "Renal Function and Chronic Kidney Disease in Aging (R01)" opportunity (PA-12-211)?
PA-12-211 is an NIH research grant announcement that supported investigator-initiated R01 projects focused on chronic kidney disease (CKD) as it relates to aging and older adults. The aim was to deepen scientific understanding of how CKD develops, progresses, and affects health later in life, and to help translate that knowledge into clearer, evidence-based guidance for diagnosing, preventing, and treating CKD in older people.
Which NIH institutes led and partnered on this funding opportunity?
The opportunity was led by the National Institute on Aging (NIA) in partnership with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
What funding mechanism did this opportunity use?
This opportunity used the NIH R01 research project grant mechanism and supported investigator-initiated research projects.
What kinds of research approaches were encouraged?
The announcement encouraged a broad range of research approaches, including basic science, clinical research, and translational science, as long as the work aligned with CKD in the context of aging and older adults.
What were the main scientific themes or topic areas?
Projects were expected to align with one or more of four themes: (1) basic research on the biology and pathophysiology of CKD in animal models; (2) research on etiology and pathophysiology of CKD in older adults; (3) epidemiology and risk-factor studies related to CKD risk, incidence, progression, and disparities with advancing age; and (4) diagnosis, medical management, and clinical outcomes for older adults with CKD.
What did the FOA say about basic research in animal models?
It invited mechanistic work in animal models examining age-related changes in renal structure and function, pathways that accelerate kidney injury with age, and biological processes that could be targeted for prevention or therapy.
What did the FOA emphasize about CKD etiology and pathophysiology in older adults?
It supported research examining why CKD arises or worsens in later life and how aging physiology interacts with common comorbidities and exposures that may influence kidney disease development or progression.
What types of epidemiology and risk-factor studies fit this opportunity?
It called for studies that clarify how CKD risk changes with advancing age, identify predictors of incident CKD or progression in older populations, and improve understanding of population patterns and disparities.
What clinical topics were included under diagnosis, management, and outcomes?
The FOA encouraged research that refines diagnostic strategies for older adults, evaluates management approaches in real-world aging populations, and links care decisions to clinical outcomes that matter in older age.
Was the focus only on kidney-centered outcomes?
No. A central emphasis was on CKD consequences in aging, encouraging applicants to address broader health impacts of CKD in older people in addition to kidney-centered outcomes.
How did the announcement frame the clinical decision-making need in older adults?
It highlighted that CKD in older adults often intersects with multimorbidity, functional limitations, medication complexity, and heterogeneous risk profiles, and it encouraged research that can improve evidence for clinical decision-making in this context.
What examples of practical research needs were mentioned?
The description included building better evidence for interpreting kidney function measures in older adults, balancing benefits and harms of interventions, and understanding how CKD influences downstream outcomes over time.
Was cost sharing or matching required?
No. The opportunity did not require cost sharing or matching.
Is PA-12-211 still open for new applications?
No. It was posted on June 13, 2012, had a closing date of September 7, 2015, and was archived on October 8, 2015. Archived opportunities are no longer open for new submissions under that specific announcement.
If it is archived, why is this announcement still useful?
Even though it is not open for new submissions, the description can still be useful as a statement of program priorities and may have been succeeded by related or reissued NIH notices or funding opportunity announcements in the same topic area.
Who was eligible to apply?
Eligibility was broad and included many types of domestic and international applicants, including government entities, higher education institutions (public and private), nonprofits (with or without 501(c)(3) status), and for-profit organizations (other than small businesses), along with a range of mission-focused and community-based organizations.
Which U.S. government entities were listed as eligible?
Eligible U.S. applicants included state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Were colleges and universities eligible?
Yes. Public and state-controlled institutions of higher education and private institutions of higher education were included as eligible applicants.
Were nonprofits eligible, and did they need 501(c)(3) status?
Nonprofits were eligible whether or not they had 501(c)(3) status.
Were for-profit organizations eligible?
Yes, for-profit organizations were eligible, except that small businesses were excluded in the eligibility language provided.
Did the eligibility language specifically include certain institution types (such as HBCUs or tribal colleges)?
Yes. The eligibility language explicitly included Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and tribal governments (federally recognized and other than federally recognized).
Were U.S. territories or regional organizations eligible?
Yes. The eligibility language included regional organizations and U.S. territories or possessions.
Were faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations were explicitly included.
Could foreign organizations apply?
Yes. Foreign institutions were eligible to apply. In addition, non-U.S. components of U.S. organizations were eligible, and foreign components were allowed as defined by NIH policy.
What NIH assistance listings (CFDA numbers) were associated with this opportunity?
The opportunity was associated with 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) and 93.866 (Aging Research), reflecting the joint NIDDK and NIA sponsorship.
Where can the archived announcement be found?
The full archived announcement was made available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-12-211.html.
Who was listed as a contact for access or linking issues?
The NIH Office of Extramural Research (OER) provided a webmaster contact for access or linking issues: FBOWebmaster@OD.NIH.GOV.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 12 211) also looked into and applied for these:
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|---|
| George M. OBrien Kidney Research Core Centers (P30) Apply for RFA DK 12 008 Funding Number: RFA DK 12 008 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $750,000 |
| Research Enhancement for NIDDK Hematology Grantees (Admin Supp) Apply for PA 12 242 Funding Number: PA 12 242 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| New Technologies for the Study of Lymphatics in the Digestive and Urinary Systems (R43/R44) Apply for PA 12 258 Funding Number: PA 12 258 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $150,000 |
| Lymphatics in Health and Disease in the Digestive, Urinary, Cardiovascular and Pulmonary Systems (R01) Apply for PAR 12 259 Funding Number: PAR 12 259 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $250,000 |
| Lymphatics in Health and Disease in the Digestive, Cardiovascular and Pulmonary Systems (R21) Apply for PAR 12 260 Funding Number: PAR 12 260 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $125,000 |
| Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) Apply for PAR 12 265 Funding Number: PAR 12 265 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Assessment, Serial Evaluation and Subsequent Sequelae of Acute Kidney Injury (ASSESS AKI) Study (U01) Apply for RFA DK 12 509 Funding Number: RFA DK 12 509 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Pilot Studies of Candidate Therapies for Chronic Kidney Disease (CKD) (U01) Apply for RFA DK 12 016 Funding Number: RFA DK 12 016 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) (U01) Apply for RFA DK 12 017 Funding Number: RFA DK 12 017 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01) Apply for RFA DK 12 508 Funding Number: RFA DK 12 508 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Advancing Clinical Research in Primary Glomerular Diseases (UM1) Apply for RFA DK 12 014 Funding Number: RFA DK 12 014 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Novel Interventions to Reduce Morbidity and Mortality of Hemodialysis Patients Safety and Other Early Phase Studies (U01) Apply for RFA DK 12 010 Funding Number: RFA DK 12 010 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Multidisciplinary K12 Urologic Research (KURe) Career Development Program Apply for RFA DK 12 013 Funding Number: RFA DK 12 013 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $600,000 |
| Limited Competition Small Grant Program for NIDDK K01/K08/K23 Recipients (R03) Apply for PAR 12 285 Funding Number: PAR 12 285 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $50,000 |
| George M. OBrien Urology Cooperative Research Centers Program (U54) Apply for RFA DK 12 009 Funding Number: RFA DK 12 009 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $650,000 |
| Ancillary Studies of Acute Kidney Injury, Chronic Kidney Disease, and End Stage Renal Disease Accessing Information from Clinical Trials, Epidemiological Studies, and Databases (R01) Apply for PA 12 299 Funding Number: PA 12 299 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Early Stage Pharmacological Validation of Novel Targets and Accompanying Pre Therapeutic Leads for Diseases of Interest to the NIDDK (R01) Apply for PAR 13 007 Funding Number: PAR 13 007 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $500,000 |
| New Directions in Hematology Research (SHINE II) (R01) Apply for PAS 13 006 Funding Number: PAS 13 006 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $200,000 |
| Limited Competition Data Coordinating Center for The Environmental Determinants of Diabetes in the Young (TEDDY) Study (UC4) Apply for RFA DK 12 510 Funding Number: RFA DK 12 510 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Research Using Biosamples from Selected Type 1 Diabetes Clinical Studies (DP3) Apply for PAR 13 013 Funding Number: PAR 13 013 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
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