Opportunity Information: Apply for PA 09 166
Apply for PA 09 166
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Renal Function and Chronic Kidney Disease in Aging (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Apr 17, 2009 and posted on Apr 17, 2009.
- Applicants must submit their applications by May 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Public housing authorities/Indian housing authorities State governments Small businesses Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments Public and State controlled institutions of higher education Independent school districts County governments Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Renal Function and Chronic Kidney Disease in Aging (R21) opportunity (Funding Opportunity Number PA 09 166) is a National Institutes of Health program led by the National Institute on Aging that supports exploratory and developmental research aimed at understanding chronic kidney disease (CKD) specifically in the context of aging and older adults. The core intent is to stimulate new, potentially high-impact ideas that clarify how CKD develops, progresses, and affects health and functioning later in life, and to generate evidence that can ultimately improve how CKD is identified, prevented, and treated in older populations.
The scientific scope is broad across the research pipeline and welcomes basic, clinical, and translational projects, as long as they center on CKD and its consequences in aging. Priority areas include four major themes: first, studies of the biology and pathophysiology of CKD using animal models, which could help explain age-related changes in renal structure, inflammation, fibrosis, vascular function, or repair mechanisms. Second, investigations into the etiology and pathophysiology of CKD in elderly humans, emphasizing why older adults may develop kidney disease differently, experience distinct trajectories of decline, or have different susceptibility to injury and impaired recovery. Third, epidemiology and risk factor research focused on how CKD emerges with advancing age, including population-level patterns and determinants that may include comorbidities, medication exposures, social and behavioral factors, and age-associated physiologic changes. Fourth, research on diagnosis, medical management, and clinical outcomes of CKD in older persons, including how CKD is detected and staged in late life, how treatment decisions are made in the presence of multimorbidity and frailty, and how CKD influences outcomes such as disability, hospitalization, cognitive decline, cardiovascular events, and mortality.
This FOA uses the NIH Exploratory/Developmental Grant mechanism (R21), which is typically used for early-stage or proof-of-concept work where investigators are testing new approaches, generating preliminary data, or exploring novel hypotheses that may later justify a larger R01-scale project. The announcement explicitly notes that it runs in parallel with a companion FOA of identical scientific scope under the R01 mechanism (PA 09 165), signaling that the R21 is meant for shorter, more exploratory projects while the R01 supports more mature, fully developed research programs.
In terms of funding structure, the listed award ceiling is $200,000, and the agency indicates that the size and duration of awards may vary because proposed projects can differ substantially in design and cost. The total funds awarded and the number of awards are not fixed in the announcement and will depend on the number of applications received, their quality, their proposed budgets and timelines, and program priorities at the time of award decisions. There is no cost sharing or matching requirement, which reduces barriers for applicants who cannot commit institutional matching funds.
Eligibility is expansive and includes a wide range of domestic and non-domestic applicants. Eligible organizations include public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), state and local governments, county and city or township governments, independent school districts, special district governments, public housing authorities, and Native American tribal governments and organizations (including both federally recognized and other tribal entities). The announcement also highlights eligibility for institutions and organizations that serve specific communities, such as Historically Black Colleges and Universities, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, as well as faith-based and community-based organizations. Foreign organizations and other non-U.S. entities, regional organizations, and U.S. territories or possessions are also included, which can be important for aging and CKD research that benefits from diverse populations or international comparisons.
Key administrative details indicate that the opportunity falls under the Health funding activity category and the CFDA program number 93.866 (Aging Research). It was posted and created on April 17, 2009, had an original and current closing date of May 7, 2012, and was archived on June 7, 2012. While it is archived and therefore not currently open for submission, it remains a useful reference point for understanding the NIA research priorities at the time and for shaping kidney-and-aging proposals that may fit newer NIH opportunities with similar aims. For full archived announcement details, the listed link is http://grants.nih.gov/grants/guide/pa-files/PA-09-166.html, and the NIH Office of Extramural Research webmaster contact is provided for access or linking issues.
Frequently Asked Questions (FAQs)
What is the "Renal Function and Chronic Kidney Disease in Aging (R21)" opportunity?
It is a National Institutes of Health (NIH) funding opportunity (Funding Opportunity Number PA-09-166) led by the National Institute on Aging (NIA) to support exploratory and developmental research focused on chronic kidney disease (CKD) in the context of aging and older adults.
What is the main goal of this funding opportunity?
The core intent is to stimulate new, potentially high-impact ideas that clarify how CKD develops, progresses, and affects health and functioning later in life, and to generate evidence that can improve how CKD is identified, prevented, and treated in older populations.
What types of research are supported (basic, clinical, translational)?
The scientific scope is broad and welcomes basic, clinical, and translational projects, as long as the project is centered on CKD and its consequences in aging.
What are the main scientific priority areas or themes?
The opportunity highlights four major themes:
- Biology and pathophysiology in animal models: Studies that help explain age-related changes in renal structure, inflammation, fibrosis, vascular function, or repair mechanisms.
- Etiology and pathophysiology in elderly humans: Work examining why older adults may develop kidney disease differently, experience distinct trajectories of decline, or show different susceptibility to injury and impaired recovery.
- Epidemiology and risk factors: Research on how CKD emerges with advancing age, including population patterns and determinants such as comorbidities, medication exposures, social and behavioral factors, and age-associated physiologic changes.
- Diagnosis, management, and outcomes in older persons: Studies on detection and staging in late life, treatment decisions amid multimorbidity and frailty, and outcomes such as disability, hospitalization, cognitive decline, cardiovascular events, and mortality.
Does the opportunity require a focus on older adults?
Yes. Projects should center on CKD specifically in the context of aging and older adult populations, including how CKD develops and affects health and functioning later in life.
What grant mechanism does this opportunity use?
This opportunity uses the NIH Exploratory/Developmental Grant mechanism (R21), which is commonly used for early-stage or proof-of-concept research, including testing new approaches, generating preliminary data, or exploring novel hypotheses.
How does this R21 relate to the companion R01 announcement?
The announcement notes it runs in parallel with a companion FOA of identical scientific scope under the R01 mechanism (PA-09-165). The R21 is positioned for shorter, more exploratory projects, while the R01 supports more mature, fully developed research programs.
What is the funding ceiling for an award under this opportunity?
The listed award ceiling is $200,000. The announcement also notes that award size and duration may vary depending on differences in project design and costs.
Are the number of awards and total available funds fixed?
No. The total funds awarded and the number of awards are not fixed. They depend on factors including the number of applications received, application quality, proposed budgets and timelines, and program priorities at the time of award decisions.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes a wide range of domestic and non-domestic applicants. Eligible organizations include (as described in the announcement) public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and multiple levels and types of government entities.
Are state and local government entities eligible?
Yes. The opportunity lists eligibility for state and local governments, including county and city or township governments, independent school districts, special district governments, and public housing authorities.
Are Native American tribal governments and organizations eligible?
Yes. Eligibility includes Native American tribal governments and organizations, including both federally recognized and other tribal entities.
Are organizations serving specific communities explicitly included?
Yes. The announcement highlights eligibility for institutions and organizations that serve specific communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and faith-based and community-based organizations.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The announcement indicates that foreign organizations and other non-U.S. entities, regional organizations, and U.S. territories or possessions are included.
What is the funding activity category and CFDA number?
The opportunity falls under the Health funding activity category and lists CFDA program number 93.866 (Aging Research).
When was this opportunity posted, and what were the closing and archive dates?
It was posted and created on April 17, 2009. The original and current closing date listed is May 7, 2012. It was archived on June 7, 2012.
Is this opportunity currently open for submission?
No. The announcement is archived, meaning it is not currently open for submission.
Why is an archived opportunity still useful?
It can be a useful reference for understanding NIA research priorities at the time and for shaping kidney-and-aging proposals that may align with newer NIH opportunities with similar aims.
Where can I find the full archived announcement?
The archived announcement is available at: http://grants.nih.gov/grants/guide/pa-files/PA-09-166.html.
Who is listed as the contact for access or linking issues?
The NIH Office of Extramural Research webmaster contact is provided in the listing for access or linking issues.
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