Opportunity Information: Apply for RFA CA 13 016
Apply for RFA CA 13 016
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Research Answers to NCIs Provocative Questions Group A (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control.
- This funding opportunity was created on Sep 30, 2013 and posted on Sep 30, 2013.
- Applicants must submit their applications by Jun 20, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Independent school districts Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses County governments For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) State governments Public housing authorities/Indian housing authorities Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity titled "Research Answers to NCI's Provocative Questions - Group A (R01)" (Funding Opportunity Number RFA-CA-13-016) is a discretionary research grant issued by the National Institutes of Health (NIH), specifically tied to the National Cancer Institute's (NCI) Provocative Questions initiative. Its central aim is to fund bold, creative, and high-impact cancer research projects that directly tackle a defined set of stubborn problems in cancer biology, prevention, detection, diagnosis, treatment, and control. What makes this program different from broader cancer funding announcements is that it is organized around targeted "provocative questions" that highlight paradoxes, gaps, or underexplored observations in cancer research. The intention is not to cover every cancer priority area, but to push investigators toward questions that NCI believes are important and potentially transformative, yet historically have not drawn enough focused attention.
This FOA uses the NIH R01 mechanism, meaning it is designed for substantial, hypothesis-driven or problem-driven research projects that can deliver clear advances in knowledge. The funded work is expected to be innovative and responsive to the specific provocative questions defined by NCI for this group, rather than general cancer research that happens to be interesting. In practice, applicants would need to frame their proposed aims so they clearly answer or make meaningful progress on one of the identified questions, typically by bringing fresh conceptual approaches, new technologies, novel datasets, unconventional models, or interdisciplinary methods to bear on a problem that has resisted traditional approaches.
From an administrative standpoint, the opportunity was posted on September 30, 2013, with an original and final application due date of June 20, 2014, and it was archived on July 21, 2014. There is no cost-sharing or matching requirement, which is consistent with many NIH research grant programs and lowers the barrier for participation by institutions and organizations that may not be able to provide significant non-federal funds.
Eligibility is broad and includes a wide range of domestic and international applicants. Eligible organizations include public and private institutions of higher education, nonprofits with or without 501(c)(3) status (other than institutions of higher education), small businesses, and for-profit organizations that are not small businesses. Government entities at multiple levels are eligible as well, including state governments, county governments, city or township governments, special district governments, independent school districts, and certain housing authorities. The FOA also explicitly includes tribal governments and tribal organizations (both federally recognized and other than federally recognized, depending on category), and it welcomes applications from organizations serving historically underrepresented communities in biomedical research. Examples listed include Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Faith-based and community-based organizations are also included. Importantly, non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations may apply, and foreign components (as defined by NIH policy) are allowed, signaling an openness to international expertise where it strengthens the science.
The activity falls under health-related research and is associated with multiple CFDA program areas within NCI's mission space, including cancer cause and prevention research (93.393), detection and diagnosis research (93.394), treatment research (93.395), cancer biology research (93.396), and cancer control (93.399). Taken together, these classifications reflect that the provocative questions can span the full cancer research pipeline, from fundamental mechanisms to clinical implications and population-level outcomes, as long as the proposed work squarely addresses one of NCI's designated questions.
For applicants seeking the original full announcement details, NIH provided an additional information link to the archived FOA page (http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-13-016.html). For technical issues accessing or linking to the announcement, the listed point of contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Research Answers to NCI's Provocative Questions - Group A (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-CA-13-016.
Which agency is offering this grant?
This is a discretionary research grant issued by the National Institutes of Health (NIH), specifically tied to the National Cancer Institute (NCI).
What is the main purpose of this funding opportunity?
The central aim is to fund bold, creative, and high-impact cancer research projects that directly tackle a defined set of stubborn problems across cancer biology, prevention, detection, diagnosis, treatment, and control.
What makes this program different from broader cancer research funding announcements?
Rather than covering broad cancer priorities, this program is organized around targeted "provocative questions" identified by NCI. These questions are meant to highlight paradoxes, gaps, or underexplored observations in cancer research that NCI believes are important and potentially transformative, yet historically have not drawn enough focused attention.
What types of research topics are supported?
The supported topics can span the full cancer research pipeline, including fundamental mechanisms, prevention, detection, diagnosis, treatment, and cancer control, as long as the proposed project squarely addresses one of NCI's designated provocative questions for Group A.
What is meant by "provocative questions" in this context?
"Provocative questions" are targeted research questions defined by NCI to push investigators toward specific, challenging problems or overlooked observations in cancer research. The intent is to stimulate innovative work on issues that have resisted traditional approaches.
What grant mechanism does this FOA use?
This FOA uses the NIH R01 mechanism.
What does it mean that this is an R01 opportunity?
It means the opportunity is designed for substantial, hypothesis-driven or problem-driven research projects that can deliver clear advances in knowledge, with expectations that the work is innovative and directly responsive to one of the defined provocative questions.
How closely does an application need to align with the provocative questions?
The funded work is expected to be responsive to the specific provocative questions defined by NCI for this group, rather than general cancer research that is simply of interest. Applicants would need to frame their aims so they clearly answer, or make meaningful progress on, one of the identified questions.
What kinds of approaches does NCI expect or encourage for these projects?
Based on the description, applicants are expected to bring innovative elements to bear on the problem, such as fresh conceptual approaches, new technologies, novel datasets, unconventional models, or interdisciplinary methods, particularly for problems that have resisted traditional approaches.
Is cost sharing or matching required?
No. The opportunity states there is no cost-sharing or matching requirement.
When was the opportunity posted?
The opportunity was posted on September 30, 2013.
What was the application due date?
The original and final application due date was June 20, 2014.
Is the funding opportunity still open?
No. The FOA was archived on July 21, 2014, indicating it is no longer active for new submissions under that announcement.
Who is eligible to apply?
Eligibility is broad and includes domestic and international applicants across many organization types, including higher education institutions, nonprofits, small businesses, for-profit organizations that are not small businesses, and multiple levels of government entities.
Are U.S. colleges and universities eligible?
Yes. Public and private institutions of higher education are listed as eligible organizations.
Are nonprofit organizations eligible to apply?
Yes. Nonprofits with or without 501(c)(3) status (other than institutions of higher education) are eligible.
Are small businesses eligible?
Yes. Small businesses are listed among eligible applicants.
Are for-profit organizations eligible?
Yes. For-profit organizations that are not small businesses are explicitly included as eligible.
Are government organizations eligible to apply?
Yes. Multiple government entity types are eligible, including state governments, county governments, city or township governments, special district governments, independent school districts, and certain housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The FOA explicitly includes tribal governments and tribal organizations, including categories covering federally recognized entities and other-than-federally recognized entities (depending on category).
Does the FOA encourage applications from organizations serving underrepresented communities?
Yes. It welcomes applications from organizations serving historically underrepresented communities in biomedical research.
Which types of minority-serving institutions are specifically mentioned?
Examples listed include Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are included among eligible applicants.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. Non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply.
Can a non-U.S. component of a U.S. organization apply?
Yes. Non-U.S. components of U.S. organizations may apply.
Are foreign components allowed under NIH policy?
Yes. Foreign components (as defined by NIH policy) are allowed, indicating openness to international expertise when it strengthens the science.
What is the general research area for this opportunity?
The activity falls under health-related research and is focused on cancer research within NCI's mission areas.
Which CFDA program areas are associated with this FOA?
The FOA is associated with multiple CFDA areas: cancer cause and prevention research (93.393), detection and diagnosis research (93.394), treatment research (93.395), cancer biology research (93.396), and cancer control (93.399).
Where can someone find the original full announcement details?
NIH provided an archived FOA page link: http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-13-016.html
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues, the listed point of contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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| Research Answers to NCIs Provocative Questions Group A (R21) Apply for RFA CA 13 017 Funding Number: RFA CA 13 017 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research Answers to NCIs Provocative Questions Group B (R01) Apply for RFA CA 13 018 Funding Number: RFA CA 13 018 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research Answers to NCIs Provocative Questions Group C (R01) Apply for RFA CA 13 020 Funding Number: RFA CA 13 020 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research Answers to NCIs Provocative Questions Group D (R01) Apply for RFA CA 13 022 Funding Number: RFA CA 13 022 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research Answers to NCIs Provocative Questions Group D (R21) Apply for RFA CA 13 023 Funding Number: RFA CA 13 023 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research Answers to NCIs Provocative Questions Group B (R21) Apply for RFA CA 13 019 Funding Number: RFA CA 13 019 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research Answers to NCIs Provocative Questions Group C (R21) Apply for RFA CA 13 021 Funding Number: RFA CA 13 021 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research Answers to NCIs Provocative Questions Group E (R01) Apply for RFA CA 13 024 Funding Number: RFA CA 13 024 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research Answers to NCIs Provocative Questions Group E (R21) Apply for RFA CA 13 025 Funding Number: RFA CA 13 025 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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