Opportunity Information: Apply for RFA CA 12 019
Apply for RFA CA 12 019
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Research Answers to NCIs Provocative Questions Group C (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research.
- This funding opportunity was created on Sep 21, 2012 and posted on Sep 21, 2012.
- Applicants must submit their applications by Jun 20, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments Native American tribal governments (Federally recognized) Independent school districts Private institutions of higher education Small businesses Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) County governments For profit organizations other than small businesses Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity "Research Answers to NCI's Provocative Questions - Group C (R01)" (Funding Opportunity Number RFA-CA-12-019) is a discretionary research grant issued by the National Cancer Institute (NCI) within the National Institutes of Health (NIH). It is built around NCI's Provocative Questions initiative, which identifies a set of specific, carefully framed questions meant to highlight stubborn problems, puzzling contradictions, and overlooked gaps in cancer research. Rather than covering every major priority in oncology, this program intentionally narrows the focus to topics that NCI considers both important and underexplored, with the goal of pushing investigators to take fresh approaches and produce clear, testable answers to these targeted questions.
At its core, the FOA supports R01 projects, meaning applicants are expected to propose well-justified, hypothesis-driven (or otherwise rigorously designed) research plans that can deliver meaningful advances on one of the identified provocative questions. The emphasis is on sound and innovative research strategies, so proposals should not simply extend routine lines of work. Instead, they should bring new thinking, novel methods, creative experimental designs, or unusual cross-disciplinary perspectives to questions where progress has been limited. In practical terms, reviewers are likely to be looking for proposals that directly engage the specific paradox or knowledge gap embedded in a provocative question and lay out a credible path to resolving it through strong science, rather than broad or generic cancer research aims.
This FOA sits within NIH's health-related research portfolio and is associated with multiple cancer-focused CFDA program areas: 93.393 (Cancer Cause and Prevention Research), 93.394 (Cancer Detection and Diagnosis Research), 93.395 (Cancer Treatment Research), and 93.396 (Cancer Biology Research). That range signals that the provocative questions may touch the full cancer research continuum, from prevention and etiology to biology, detection, and therapy. The mechanism is a grant (not a contract), and there is no cost sharing or matching requirement, which means applicants are not required to provide non-federal funds to receive an award.
Eligibility is broad and includes many types of U.S. organizations as well as non-U.S. entities. Eligible applicants listed include public and private institutions of higher education, nonprofits with or without 501(c)(3) status, small businesses and other for-profit organizations (other than small businesses are also included), independent school districts, and multiple levels of government such as state, county, city or township, special district governments, and public housing authorities/Indian housing authorities. The eligibility language also explicitly includes a range of minority-serving and special-designation institutions and entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). In addition, federally recognized tribal governments and other tribal organizations are eligible, as are eligible federal agencies, U.S. territories or possessions, and regional organizations. Notably, foreign (non-U.S.) organizations are also listed as eligible, which opens the door for international institutions to apply when their proposed work is well aligned with the provocative questions and fits NIH policy.
From an administrative timeline standpoint, the FOA was posted and created on September 21, 2012, with an original and current closing date of June 20, 2013, and an archive date of July 21, 2013. In other words, this particular announcement is historical and is no longer accepting applications, but it remains a useful reference point for understanding how NCI structured this round of Provocative Questions funding and what kinds of projects it sought to stimulate during that cycle.
For applicants or readers who want the full text and complete requirements, NIH provided an official announcement link hosted on the NIH grants site (http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-019.html). The contact information included in the source is aimed at technical access issues, directing users to the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV) if they have trouble viewing the announcement or linking to it.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Research Answers to NCI's Provocative Questions - Group C (R01)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-CA-12-019.
Which federal agency is offering this grant?
This is a discretionary research grant issued by the National Cancer Institute (NCI), which is part of the National Institutes of Health (NIH).
What is the main purpose of this FOA?
This FOA supports research projects designed to produce clear, testable answers to NCI's Provocative Questions, which are specific, carefully framed questions intended to highlight stubborn problems, puzzling contradictions, and overlooked gaps in cancer research.
What are "Provocative Questions" in the context of this program?
Provocative Questions are a set of targeted questions identified by NCI to focus attention on areas where progress has been limited. They are designed to spotlight underexplored issues in cancer research and encourage investigators to pursue fresh approaches that address specific paradoxes or knowledge gaps.
What grant mechanism does this opportunity use?
This FOA supports the R01 mechanism, which is an NIH research project grant.
What kind of research projects is NCI looking for under this FOA?
The FOA emphasizes sound and innovative research strategies. Applicants are expected to propose well-justified, rigorously designed research plans (for example, hypothesis-driven studies or other strong designs) that directly engage one of the identified provocative questions.
Does the FOA encourage routine extensions of existing research?
No. The FOA indicates that proposals should not simply extend routine lines of work. Instead, they should bring new thinking, novel methods, creative experimental designs, or cross-disciplinary perspectives to the targeted provocative question.
How specific do the proposed aims need to be to the Provocative Questions?
Based on the FOA description, reviewers are likely to look for projects that directly address the specific paradox or knowledge gap embedded in a provocative question, rather than broad or generic cancer research aims.
What areas of cancer research can this FOA cover?
The FOA is associated with multiple cancer-focused CFDA program areas, signaling it may span the research continuum from prevention and etiology to biology, detection/diagnosis, and therapy/treatment.
Which CFDA program areas are associated with this opportunity?
- 93.393 - Cancer Cause and Prevention Research
- 93.394 - Cancer Detection and Diagnosis Research
- 93.395 - Cancer Treatment Research
- 93.396 - Cancer Biology Research
Is this funding offered as a grant or a contract?
This opportunity is offered as a grant (not a contract).
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal funds as a condition of award.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. organizations and non-U.S. entities. Eligible applicants listed include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), small businesses, other for-profit organizations, independent school districts, and multiple levels of government.
Are nonprofit organizations eligible (including those without 501(c)(3) status)?
Yes. The eligibility list includes nonprofits with or without 501(c)(3) status.
Are for-profit organizations eligible?
Yes. The eligibility list includes small businesses and also includes other for-profit organizations (in addition to small businesses).
Are K-12 or local education agencies eligible?
The eligibility list includes independent school districts.
Are government entities eligible to apply?
Yes. The eligibility list includes multiple levels of government, such as state, county, city or township, special district governments, and public housing authorities/Indian housing authorities.
Are tribal governments or tribal organizations eligible?
Yes. The eligibility language includes federally recognized tribal governments and other tribal organizations.
Are minority-serving institutions specifically included in the eligibility language?
Yes. The eligibility description explicitly includes a range of minority-serving and special-designation institutions and entities, including:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-Serving Institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
Are U.S. territories or possessions eligible?
Yes. The eligibility description includes U.S. territories or possessions.
Are foreign (non-U.S.) organizations eligible?
Yes. The eligibility list notably includes foreign (non-U.S.) organizations, indicating international institutions may apply when their work aligns with the provocative questions and fits NIH policy.
Is this FOA still open for applications?
No. This announcement is historical. The current closing date listed is June 20, 2013, and the archive date is July 21, 2013, so it is no longer accepting applications.
When was this FOA posted?
The FOA was posted/created on September 21, 2012.
Where can I find the official FOA text?
The official NIH announcement is available here: http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-12-019.html
Who should I contact if I have trouble viewing the announcement online?
For technical access issues (such as trouble viewing the announcement or linking to it), the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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| Research Answers to NCIs Provocative Questions Group C (R21) Apply for RFA CA 12 020 Funding Number: RFA CA 12 020 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research Answers to NCIs Provocative Questions Group D (R01) Apply for RFA CA 12 021 Funding Number: RFA CA 12 021 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research Answers to NCIs Provocative Questions Group D (R21) Apply for RFA CA 12 022 Funding Number: RFA CA 12 022 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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| Exceptional Unconventional Research Enabling Knowledge Acceleration (EUREKA) for Neuroscience and Disorders of the Nervous System (R01) Apply for RFA NS 13 007 Funding Number: RFA NS 13 007 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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