Opportunity Information: Apply for RFA CA 13 022
Apply for RFA CA 13 022
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Research Answers to NCIs Provocative Questions Group D (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control.
- This funding opportunity was created on Sep 30, 2013 and posted on Sep 30, 2013.
- Applicants must submit their applications by Jun 20, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public and State controlled institutions of higher education City or township governments State governments County governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Private institutions of higher education Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Research Answers to NCI's Provocative Questions Group D (R01) (Funding Opportunity Number RFA-CA-13-022) was a National Institutes of Health grant opportunity issued under the National Cancer Institute's Provocative Questions (PQ) initiative. Its central goal was to fund bold, creative R01 research projects that directly tackle a defined set of specific "problems and paradoxes" in cancer research framed as provocative, question-style challenges. The intent was not to cover every major priority in oncology, but to push investigators toward areas judged to be important yet relatively underexplored, and to spark genuinely innovative thinking that could break through stubborn conceptual or technical barriers in the field.
This FOA supported discretionary grant funding using the NIH R01 mechanism, meaning applicants were expected to propose a well-justified, hypothesis-driven (or strongly rationale-driven) research plan with clear aims, rigorous methods, and the potential for substantial impact on cancer biology, prevention, detection/diagnosis, treatment, or control. The opportunity was aligned with multiple cancer-related CFDA program areas, including cancer cause and prevention research (93.393), detection and diagnosis (93.394), treatment (93.395), cancer biology (93.396), and cancer control (93.399). In practice, that breadth signaled that NCI was open to proposals across the cancer research spectrum, as long as they were tightly responsive to one of the designated Provocative Questions in "Group D" and were positioned to produce meaningful answers rather than incremental progress.
A notable feature of the announcement was its wide eligibility. In addition to the typical university and nonprofit research applicants, eligibility extended to state and local governments, tribal governments and tribal organizations, independent school districts, special district governments, public housing authorities/Indian housing authorities, and both nonprofit and for-profit organizations (including small businesses and other for-profits). Importantly, the FOA explicitly allowed non-U.S. entities to apply, including foreign organizations and foreign institutions, and it also permitted foreign components of U.S. organizations as defined in NIH policy. The eligibility language further highlighted inclusion of a range of institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and Asian American and Native American Pacific Islander-serving institutions, as well as faith-based and community-based organizations where relevant. No cost sharing or matching requirement applied, which is consistent with standard NIH research project grants and reduces barriers for applicants whose institutions might not be able to provide matching funds.
Timeline-wise, the opportunity was posted and created on September 30, 2013, with an original and current closing date of June 20, 2014, and it was later archived on July 21, 2014. The full announcement was available via the NIH Grants Guide (link provided in the source), and applicants needing help accessing or linking to the FOA were directed to contact the NIH Office of Extramural Research (OER) webmaster via the listed email. Overall, RFA-CA-13-022 represented a targeted call for high-impact cancer research proposals that were explicitly shaped around NCI's curated list of provocative, under-addressed questions, using the R01 mechanism to support substantial, investigator-driven projects aimed at producing clear, actionable scientific answers.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "Research Answers to NCI's Provocative Questions Group D (R01)" and it was issued by the National Institutes of Health (NIH) under the National Cancer Institute (NCI) Provocative Questions (PQ) initiative.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-CA-13-022.
Who issued this grant opportunity?
This was an NIH grant opportunity issued under the National Cancer Institute (NCI).
What is the main purpose or goal of this FOA?
The central goal was to fund bold, creative R01 research projects that directly tackle a defined set of specific "problems and paradoxes" in cancer research framed as provocative, question-style challenges. The emphasis was on producing meaningful answers to designated Provocative Questions (Group D), not incremental progress.
What is the "Provocative Questions (PQ) initiative" in this context?
In this FOA, the PQ initiative refers to NCI framing important but relatively underexplored cancer research issues as explicit, provocative questions. Applicants were expected to align their proposals tightly with one of the designated questions in Group D and pursue genuinely innovative thinking to overcome stubborn conceptual or technical barriers.
Is this FOA intended to cover all major oncology priorities?
No. The stated intent was not to cover every major priority in oncology, but to push investigators toward areas judged to be important yet relatively underexplored, and to stimulate innovative approaches that could break through barriers in the field.
What grant mechanism does this opportunity use?
This FOA used the NIH R01 mechanism (Research Project Grant).
What type of research approach was expected under this R01 FOA?
Applicants were expected to propose a well-justified, hypothesis-driven (or strongly rationale-driven) research plan with clear aims, rigorous methods, and the potential for substantial impact. The expectation was that the project would be positioned to produce meaningful answers to a specified Group D Provocative Question.
What kinds of cancer research areas could be supported?
The FOA signaled openness across the cancer research spectrum, including cancer biology, prevention, detection/diagnosis, treatment, and control, as long as the proposal was tightly responsive to one of the designated Group D Provocative Questions.
Which CFDA program areas were associated with this opportunity?
The FOA was aligned with multiple cancer-related CFDA program areas, including:
- 93.393 (cancer cause and prevention research)
- 93.394 (detection and diagnosis)
- 93.395 (treatment)
- 93.396 (cancer biology)
- 93.399 (cancer control)
Who was eligible to apply?
Eligibility was broad. It included typical university and nonprofit research applicants, and also extended to state and local governments, tribal governments and tribal organizations, independent school districts, special district governments, public housing authorities/Indian housing authorities, and both nonprofit and for-profit organizations (including small businesses and other for-profits).
Are for-profit organizations allowed to apply?
Yes. The eligibility explicitly included both nonprofit and for-profit organizations, including small businesses and other for-profits.
Are government entities allowed to apply?
Yes. Eligibility extended to state and local governments, tribal governments and tribal organizations, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA explicitly allowed non-U.S. entities to apply, including foreign organizations and foreign institutions.
Are foreign components of U.S. organizations allowed?
Yes. The FOA permitted foreign components of U.S. organizations as defined in NIH policy.
Did the FOA mention any specific institution types as included in eligibility?
Yes. The eligibility language highlighted inclusion of a range of institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and Asian American and Native American Pacific Islander-serving institutions, as well as faith-based and community-based organizations where relevant.
Is cost sharing or matching required?
No. The FOA stated that no cost sharing or matching requirement applied.
When was this opportunity posted/created?
The opportunity was posted and created on September 30, 2013.
What was the application closing date?
The original and current closing date was June 20, 2014.
Is this funding opportunity still active?
No. It was later archived on July 21, 2014.
Where was the full announcement made available?
The full announcement was available via the NIH Grants Guide (a link was provided in the source information).
Who could applicants contact for help accessing or linking to the FOA?
Applicants needing help accessing or linking to the FOA were directed to contact the NIH Office of Extramural Research (OER) webmaster via the listed email in the announcement.
What made this FOA distinct compared to broader cancer research solicitations?
It was a targeted call focused on NCI's curated list of Provocative Questions (specifically Group D). The defining feature was a requirement for tight responsiveness to one of those questions and an emphasis on bold, creative work designed to produce clear, actionable scientific answers rather than incremental advances.
What level of impact was NCI aiming for with supported projects?
The intent was to support projects with the potential for substantial impact on cancer biology, prevention, detection/diagnosis, treatment, or control, especially by addressing underexplored but important problems framed as provocative questions.
Browse more opportunities from the same category: Education Health
Next opportunity: Research Answers to NCIs Provocative Questions Group D (R21)
Previous opportunity: Research Answers to NCIs Provocative Questions Group C (R01)
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Applicants who have applied for this opportunity (RFA CA 13 022) also looked into and applied for these:
| Funding Opportunity |
|---|
| Research Answers to NCIs Provocative Questions Group D (R21) Apply for RFA CA 13 023 Funding Number: RFA CA 13 023 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research Answers to NCIs Provocative Questions Group B (R21) Apply for RFA CA 13 019 Funding Number: RFA CA 13 019 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research Answers to NCIs Provocative Questions Group C (R21) Apply for RFA CA 13 021 Funding Number: RFA CA 13 021 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research Answers to NCIs Provocative Questions Group E (R01) Apply for RFA CA 13 024 Funding Number: RFA CA 13 024 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research Answers to NCIs Provocative Questions Group E (R21) Apply for RFA CA 13 025 Funding Number: RFA CA 13 025 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Interpreting Variation in Human Non Coding Genomic Regions Using Computational Approaches and Experimental Assessment (R01) Apply for RFA HG 13 013 Funding Number: RFA HG 13 013 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Planning for a National Center for Particle Beam Radiation Therapy Research (P20) Apply for PAR 13 371 Funding Number: PAR 13 371 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Research on Malignancies in the Context of HIV/AIDS (R21) Apply for PA 13 378 Funding Number: PA 13 378 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research on Malignancies in the Context of HIV/AIDS (R01) Apply for PA 13 377 Funding Number: PA 13 377 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Sub Saharan African Collaborative HIV and Cancer Consortia (U54) Apply for RFA CA 13 010 Funding Number: RFA CA 13 010 Agency: National Institutes of Health Category: Education Health Funding Amount: $750,000 |
| FY 2014 American Schools and Hospitals Abroad (ASHA) Program Apply for APS ASHA 14 000001 Funding Number: APS ASHA 14 000001 Agency: Agency for International Development Category: Education Health Funding Amount: $2,000,000 |
| Cancer Detection, Diagnostic and Treatment Technologies for Global Health (UH2/UH3) Apply for RFA CA 13 015 Funding Number: RFA CA 13 015 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Population based Research Optimizing Screening through Personalized Regimens (PROSPR) Revision to Enhance the Collection of Cervical Cancer Screening Data (U54) Apply for RFA CA 14 001 Funding Number: RFA CA 14 001 Agency: National Institutes of Health Category: Education Health Funding Amount: $650,000 |
| Cancer Center Support Grants (CCSGs) for NCI designated Cancer Centers (P30) Apply for PAR 13 386 Funding Number: PAR 13 386 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Low Cost, Pragmatic, Patient Centered Randomized Controlled Intervention Trials (UH2/UH3) Apply for RFA HL 14 019 Funding Number: RFA HL 14 019 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Development of Opioid and Adjuvant Fixed Combination Dosage Forms for the Treatment of Chronic Pain with Reduced Addiction Potential (R41/R42) Apply for PA 13 388 Funding Number: PA 13 388 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Development of Opioid and Adjuvant Fixed Combination Dosage Forms for the Treatment of Chronic Pain with Reduced Addiction Potential (R43/R44) Apply for PA 13 387 Funding Number: PA 13 387 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NCI Community Oncology Research Program(NCORP) Community Sites (UM1) Apply for RFA CA 13 013 Funding Number: RFA CA 13 013 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NCI Community Oncology Research Program (NCORP) Research Bases (UM1) Apply for RFA CA 13 012 Funding Number: RFA CA 13 012 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NCI Community Oncology Research Program (NCORP) Minority/Underserved Community Sites (UM1) Apply for RFA CA 13 014 Funding Number: RFA CA 13 014 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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