Opportunity Information: Apply for RFA CA 16 006
Apply for RFA CA 16 006
- The HHS-NIH11 in the education, health sector is offering a public funding opportunity titled "Research Centers for Barretts Esophagus Translational Research Network (BETRNet)(U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396.
- This funding opportunity was created on Mar 17, 2016 and posted on Mar 17, 2016.
- Applicants must submit their applications by May 23, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $900,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Research Centers for Barretts Esophagus Translational Research Network (BETRNet) (U54) funding opportunity (RFA-CA-16-006) is a National Cancer Institute (NCI) cooperative agreement designed to build a coordinated, multi-institutional set of translational research centers focused on Barretts esophagus and esophageal adenocarcinoma. The central purpose is to respond to the rising incidence of esophageal adenocarcinoma in the United States by strengthening and accelerating research that connects basic biological insights to practical strategies for prevention, early detection, and improved clinical management. The program is built around the idea that a deeper, validated understanding of the biology of esophageal adenocarcinoma and its key precursor lesion, Barretts esophagus, is necessary to develop preventive measures that genuinely improve patient outcomes.
Under this announcement, NCI planned to support three to four Research Centers that would function as the primary scientific and clinical engines of the BETRNet program. These centers are expected to be trans-disciplinary and multi-institutional, meaning they should bring together complementary expertise across fields (for example, clinical gastroenterology, oncology, pathology, epidemiology, genomics, immunology, computational biology, and bioinformatics) and coordinate efforts across more than one organization when appropriate. The emphasis on translational work signals that proposed activities should not sit purely in the basic science lane or purely in clinical observation; they should be structured to move knowledge along the pipeline toward usable interventions, tools, or evidence that can shape prevention and patient care.
BETRNet is structured as a network rather than a collection of isolated awards. In addition to the Research Centers supported by this FOA, the program includes a single Coordinating Center funded through a companion announcement (RFA-CA-16-007). The Coordinating Center is intended to enable the network to function as a unified program by supporting and organizing major shared activities. In particular, it facilitates network interactions and collaborations, manages or supports participation in a patient registry and virtual biorepository, and helps organize cross-network pilot projects. This means awardees are expected to operate with an explicit commitment to collaboration, shared standards, and active participation in network-wide initiatives rather than pursuing only center-specific priorities.
A major shared component of BETRNet is the patient registry-virtual biorepository, which is meant to serve as a centralized, shared resource for the entire program. The goal of this platform is to enable broader and faster progress by making well-annotated patient data and associated biospecimen resources accessible across the network under appropriate governance and protections. By supporting shared access to harmonized clinical data and biospecimens, the registry/biorepository is positioned to reduce duplication, increase statistical power, improve reproducibility, and allow researchers to test and validate findings across multiple sites and patient populations.
Administratively, this opportunity was offered as a cooperative agreement (U54), which typically indicates substantial scientific or programmatic involvement by the NIH compared with a standard research project grant. The sponsoring agency is the U.S. Department of Health and Human Services, National Institutes of Health, with NCI as the program lead (listed as HHS-NIH11). The activity category is listed under Education and Health, and the associated CFDA numbers are 93.393, 93.394, 93.395, and 93.396. The announcement was posted on March 17, 2016, created the same day, and had a closing date of May 23, 2016.
In terms of funding expectations, the award ceiling listed is $900,000, and the program anticipated making about four awards under this FOA, aligning with the stated plan to fund three to four Research Centers. Eligibility was broad and included state and county governments, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status, excluding higher education institutions in those categories), for-profit organizations other than small businesses, small businesses, and other entities as described in the FOA’s additional eligibility details. Overall, the opportunity was designed to create a tightly connected research network capable of producing shared resources, coordinated studies, and collaborative pilot efforts that collectively push the Barretts esophagus and esophageal adenocarcinoma field toward validated prevention and better patient management.
BETRNet (U54) RFA-CA-16-006: Frequently Asked Questions (FAQs)
1) What is the BETRNet U54 funding opportunity (RFA-CA-16-006)?
BETRNet stands for the Research Centers for Barretts Esophagus Translational Research Network. RFA-CA-16-006 is a National Cancer Institute (NCI) cooperative agreement (U54) intended to build a coordinated, multi-institutional network of translational research centers focused on Barretts esophagus and esophageal adenocarcinoma.
2) What problem is this program designed to address?
The program is designed to respond to the rising incidence of esophageal adenocarcinoma in the United States by strengthening and accelerating research that connects basic biological insights to practical strategies for prevention, early detection, and improved clinical management.
3) What is the central purpose of BETRNet?
The central purpose is to accelerate translational research that links biological understanding of esophageal adenocarcinoma and its key precursor lesion, Barretts esophagus, to usable interventions, tools, or evidence that can improve prevention and patient outcomes.
4) What does "translational research" mean in the context of this opportunity?
In this program, translational research means proposed activities should be structured to move knowledge along a pipeline from basic biological insights toward practical strategies for prevention, early detection, and better clinical management, rather than remaining only in basic science or only in clinical observation.
5) How many awards did NCI expect to make under this FOA?
The program anticipated making about four awards under this FOA, aligning with the plan to support three to four Research Centers.
6) What is the award ceiling listed for this opportunity?
The award ceiling listed is $900,000.
7) What type of funding mechanism is used (U54), and what does it imply?
This opportunity uses a cooperative agreement mechanism (U54). As described in the opportunity summary, this typically indicates substantial scientific or programmatic involvement by NIH compared with a standard research project grant.
8) Which agency is sponsoring and leading this opportunity?
The sponsoring agency is the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), with the National Cancer Institute (NCI) as the program lead (listed as HHS-NIH11).
9) What is the overall structure of BETRNet?
BETRNet is structured as a network rather than a set of isolated awards. It includes Research Centers funded under RFA-CA-16-006 and a single Coordinating Center funded through a companion announcement (RFA-CA-16-007).
10) What is the companion funding announcement, and what is it for?
The companion announcement is RFA-CA-16-007, which funds a single Coordinating Center. The Coordinating Center is intended to enable the network to operate as a unified program by supporting and organizing major shared activities.
11) What are Research Centers expected to be like?
Research Centers are expected to be trans-disciplinary and multi-institutional. This means bringing together complementary expertise across fields and coordinating efforts across more than one organization when appropriate.
12) What kinds of expertise are relevant for a BETRNet Research Center?
Examples of relevant expertise listed include clinical gastroenterology, oncology, pathology, epidemiology, genomics, immunology, computational biology, and bioinformatics.
13) Are awardees expected to collaborate across the network?
Yes. The program description emphasizes that awardees are expected to operate with an explicit commitment to collaboration, shared standards, and active participation in network-wide initiatives, rather than pursuing only center-specific priorities.
14) What shared resources or shared components are central to BETRNet?
A major shared component is a patient registry-virtual biorepository intended to serve as a centralized, shared resource for the entire program.
15) What is the purpose of the patient registry-virtual biorepository?
The goal is to enable broader and faster progress by making well-annotated patient data and associated biospecimen resources accessible across the network under appropriate governance and protections.
16) What benefits does a shared registry/biorepository provide to the network?
As described, shared access to harmonized clinical data and biospecimens can reduce duplication, increase statistical power, improve reproducibility, and allow researchers to test and validate findings across multiple sites and patient populations.
17) What kinds of network-wide activities does the Coordinating Center support?
The Coordinating Center facilitates network interactions and collaborations, manages or supports participation in a patient registry and virtual biorepository, and helps organize cross-network pilot projects.
18) Does the opportunity emphasize prevention and early detection?
Yes. The stated focus includes practical strategies for prevention, early detection, and improved clinical management related to Barretts esophagus and esophageal adenocarcinoma.
19) What is the key precursor lesion highlighted in the opportunity?
Barretts esophagus is described as the key precursor lesion to esophageal adenocarcinoma.
20) What is meant by building a "coordinated, multi-institutional set" of centers?
It means the program is intended to link multiple translational research centers into a single, coordinated network where sites align on shared efforts, participate in network-wide initiatives, and contribute to common resources such as the registry/biorepository.
21) When was this funding announcement posted, and what were the key dates?
The announcement was posted on March 17, 2016, created the same day, and had a closing date of May 23, 2016.
22) What is the activity category listed for this opportunity?
The activity category is listed under Education and Health.
23) What CFDA numbers are associated with this opportunity?
The associated CFDA numbers listed are 93.393, 93.394, 93.395, and 93.396.
24) Who is eligible to apply (in general terms)?
Eligibility is described as broad and includes state and county governments; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (with and without 501(c)(3) status, excluding higher education institutions in those categories); for-profit organizations other than small businesses; small businesses; and other entities as described in the FOA's additional eligibility details.
25) Is this program intended to support independent projects or an integrated network?
It is intended to support an integrated network. The description explicitly frames BETRNet as a network with shared resources and coordinated studies, rather than a collection of isolated awards.
26) What outcomes is the overall program aiming to accelerate?
The program aims to accelerate validated prevention approaches and better patient management by strengthening and speeding research that connects biological insights to practical strategies and by enabling coordinated studies and shared resources across sites.
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