Opportunity Information: Apply for PA 13 237
Apply for PA 13 237
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research Grants Using the Resources from the Osteoarthritis Initiative (OAI)(R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.866 Aging Research.
- This funding opportunity was created on May 31, 2013 and posted on May 31, 2013.
- Applicants must submit their applications by Jan 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Public housing authorities/Indian housing authorities Small businesses State governments Native American tribal organizations (other than Federally recognized tribal governments) Special district governments For profit organizations other than small businesses County governments City or township governments Independent school districts Native American tribal governments (Federally recognized) Private institutions of higher education Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH Funding Opportunity Announcement PA-13-237, titled "Research Grants Using the Resources from the Osteoarthritis Initiative (OAI) (R21)," was a discretionary grant program designed to stimulate new, exploratory research that makes direct use of the Osteoarthritis Initiative's publicly available resources. The central purpose was to broaden and deepen the scientific community's use of the OAI database by encouraging investigators to leverage its rich collection of longitudinal clinical information, imaging (notably MRI and X-ray), and associated data assets. By issuing this FOA, NIAMS and its partners were signaling to applicants and peer reviewers that studies grounded in OAI data were a high priority, especially projects that could quickly generate new hypotheses, methods, or early-stage findings relevant to osteoarthritis.
The opportunity specifically emphasized research that could advance understanding of osteoarthritis (OA) onset, progression, and outcomes, with a strong focus on knee OA and also including hip OA. A major theme was risk factor discovery and validation, spanning both modifiable factors (such as body weight, activity patterns, biomechanics, or other potentially changeable exposures) and non-modifiable factors (such as age, sex, genetics, or baseline anatomy). Another highlighted direction was the use of available biospecimens alongside clinical and imaging measures to identify biochemical markers of early disease or markers that predict faster progression. The FOA also encouraged studies that analyze existing OAI data to evaluate how participants respond to OA pain in real-world settings, including the effectiveness or associations of biobehavioral strategies, pharmacologic treatments, and other interventions that subjects may already be using.
Imaging-based work was a particularly prominent focus. The announcement called out projects examining whether MRI-detected changes can predict later radiographic deterioration or worsening clinical outcomes, which aligns with the need for earlier and more sensitive indicators than traditional radiographs alone. In addition, the FOA encouraged method development: creating novel, efficient, and reproducible tools to analyze large volumes of MRI and X-ray images. This includes approaches that improve diagnostic consistency, automate or standardize measurements, and support monitoring of OA-related structural change at scale. Beyond cartilage-focused outcomes, the FOA also invited research on the broader trajectory of disease, including effects on other joint-related structures such as muscle, ligaments, and bone. The goal in this area was to better identify points in the disease course where interventions could be introduced, including tailored approaches for specific subgroups, to reduce severity or slow progression.
Administratively, this was an NIH grant mechanism under the R21 activity code, which generally supports early-stage, exploratory, and developmental projects rather than large, definitive trials. The listed award ceiling was $200,000, and the announcement indicated no cost sharing or matching requirement. The program fell under NIH and aligned with health-related research activity, with CFDA numbers including 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research), 93.866 (Aging Research), and 93.213 (Research and Training in Complementary and Integrative Health), reflecting the cross-cutting nature of OA research and the range of relevant scientific approaches.
Eligibility was broad and included many types of domestic and non-domestic organizations. Eligible applicants encompassed public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit entities, small businesses, state and local governments, tribal governments and tribal organizations, school districts, public housing authorities, regional organizations, faith-based or community-based organizations, and U.S. territories or possessions. The FOA also explicitly allowed foreign organizations and foreign components of U.S. organizations, consistent with NIH policy permitting appropriately justified international involvement.
In terms of timing, the FOA was posted and created on May 31, 2013, with an original and current closing date listed as January 7, 2016, and an archive date of February 7, 2016, meaning the opportunity is no longer active but remains relevant as a reference for the type of NIH-funded work that leverages OAI resources. For full details, NIH provided the official announcement link at http://grants.nih.gov/grants/guide/pa-files/PA-13-237.html and directed technical access questions to the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).
FAQs: NIH PA-13-237 - Research Grants Using the Resources from the Osteoarthritis Initiative (OAI) (R21)
What is NIH Funding Opportunity Announcement (FOA) PA-13-237?
PA-13-237 was an NIH discretionary funding opportunity titled "Research Grants Using the Resources from the Osteoarthritis Initiative (OAI) (R21)." It was designed to stimulate new, exploratory research projects that make direct use of the Osteoarthritis Initiative's publicly available resources, especially the OAI database and related data assets.
What was the main purpose of this FOA?
The central goal was to broaden and deepen the scientific community's use of the Osteoarthritis Initiative (OAI) resources by encouraging investigators to leverage its longitudinal clinical information, imaging data (notably MRI and X-ray), and associated assets. NIH (including NIAMS and partners) emphasized that OAI-based studies were a high priority for generating new hypotheses, methods, or early-stage findings relevant to osteoarthritis.
What type of grant mechanism did PA-13-237 use?
This FOA used the NIH R21 activity code, which generally supports early-stage, exploratory, and developmental research rather than large, definitive clinical trials.
What was the maximum award amount under this opportunity?
The listed award ceiling was $200,000.
Was cost sharing or matching required?
No. The FOA indicated there was no cost sharing or matching requirement.
What research areas and topics were emphasized?
The FOA emphasized research that could advance understanding of osteoarthritis (OA) onset, progression, and outcomes. It highlighted risk factor discovery and validation, imaging-based predictors of disease change, analysis of biospecimens for biochemical markers, studies of pain response and real-world treatment use, and method development for efficient, reproducible analysis of large imaging datasets.
Was the focus only on knee osteoarthritis?
No. The opportunity had a strong focus on knee OA but also included hip OA.
What kinds of risk factors did the FOA encourage applicants to study?
It encouraged work on both modifiable risk factors (such as body weight, activity patterns, biomechanics, or other potentially changeable exposures) and non-modifiable risk factors (such as age, sex, genetics, or baseline anatomy).
Did the FOA encourage studies using biospecimens?
Yes. It highlighted using available biospecimens alongside clinical and imaging measures to identify biochemical markers of early disease and/or markers that predict faster progression.
What did the FOA say about studying osteoarthritis pain and treatments?
It encouraged studies analyzing existing OAI data to evaluate how participants respond to OA pain in real-world settings, including associations related to biobehavioral strategies, pharmacologic treatments, and other interventions that subjects may already be using.
Why was imaging such a prominent focus in PA-13-237?
Imaging-based research was emphasized because the FOA called for projects examining whether MRI-detected changes can predict later radiographic deterioration or worsening clinical outcomes. This aligns with the need for earlier and more sensitive indicators than traditional radiographs alone.
What kinds of imaging data were specifically mentioned?
The FOA specifically called out MRI and X-ray imaging resources as part of the OAI data assets investigators were expected to use directly.
Did the FOA support methods development for imaging analysis?
Yes. It encouraged creation of novel, efficient, and reproducible tools to analyze large volumes of MRI and X-ray images. Examples included approaches to improve diagnostic consistency, automate or standardize measurements, and support monitoring of OA-related structural change at scale.
Was the research scope limited to cartilage outcomes?
No. Beyond cartilage-focused outcomes, the FOA invited research on the broader trajectory of osteoarthritis, including effects on other joint-related structures such as muscle, ligaments, and bone.
What broader disease-course questions did NIH encourage investigators to address?
The FOA encouraged research aimed at identifying points in the disease course where interventions could be introduced, including tailored approaches for specific subgroups, with the goal of reducing severity or slowing progression.
What does it mean that OAI resources are "publicly available"?
Based on the FOA description, the Osteoarthritis Initiative provides publicly available resources that include a rich collection of longitudinal clinical information, imaging (MRI and X-ray), and related data assets intended for the research community to use.
Who was eligible to apply?
Eligibility was broad and included many types of domestic and non-domestic organizations, including public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit entities; small businesses; state and local governments; tribal governments and tribal organizations; school districts; public housing authorities; regional organizations; faith-based or community-based organizations; and U.S. territories or possessions.
Were foreign organizations allowed to apply?
Yes. The FOA explicitly allowed foreign organizations and foreign components of U.S. organizations, consistent with NIH policy permitting appropriately justified international involvement.
Which NIH areas or programs did this FOA align with (CFDA numbers)?
The FOA listed CFDA numbers including 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research), 93.866 (Aging Research), and 93.213 (Research and Training in Complementary and Integrative Health), reflecting the cross-cutting nature of osteoarthritis research and multiple relevant scientific approaches.
When was this FOA posted, and when did it close?
The FOA was posted and created on May 31, 2013. The original and current closing date was listed as January 7, 2016, and the archive date was February 7, 2016.
Is this funding opportunity still active?
No. The FOA is no longer active because it reached its closing date and was archived. It may still be useful as a reference for the type of NIH-funded work that leverages Osteoarthritis Initiative (OAI) resources.
Where can applicants or researchers find the official FOA text?
NIH provided the official announcement link at: http://grants.nih.gov/grants/guide/pa-files/PA-13-237.html
Who was listed as a contact for technical access questions?
For technical access questions, NIH directed inquiries to the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
What types of outcomes or deliverables was this FOA trying to accelerate?
It was intended to accelerate exploratory outcomes such as new hypotheses, new analytical methods (especially for imaging), early-stage findings about osteoarthritis onset/progression/outcomes, identification or validation of risk factors, and early indicators (including biomarkers and MRI-based predictors) that could help predict deterioration or worsening clinical outcomes.
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