Research on Alcohol and HIV/AIDS (R21) | Apply Online

Opportunity Summary:

The Research on Alcohol and HIV/AIDS (R21) opportunity (Funding Opportunity Number PA-07-063) is a National Institutes of Health grant announcement from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). It uses the Exploratory/Developmental Research Grant mechanism (R21), which is designed for early-stage, innovative, and high-impact projects that are still in the exploratory phase and may not yet have extensive preliminary data. The central purpose of this FOA is to support research that clarifies how alcohol use, drinking patterns, and the environments where drinking occurs shape HIV/AIDS outcomes across the full continuum, from risk and transmission to disease progression and clinical management.

At its core, the FOA is looking for studies that identify and characterize the role of alcohol in the epidemiology and natural history of HIV/AIDS, as well as in HIV pathogenesis, prevention, treatment, and control. In practical terms, that means proposals can focus on how alcohol affects behaviors that increase HIV exposure risk, how alcohol influences adherence to prevention or treatment strategies, and how alcohol use may interact with biological processes that affect infection susceptibility, immune function, viral dynamics, comorbidities, and overall disease course. The announcement also explicitly highlights drinking behaviors and drinking environments, signaling interest not only in individual-level consumption but also in contextual factors such as social settings, bars and clubs, community norms, structural determinants, and environmental conditions that may shape both alcohol use and HIV-related outcomes.

Because this is an R21, the grant is intended to fund exploratory or developmental work, such as piloting new interventions, testing novel measurement approaches, establishing feasibility for larger-scale studies, generating preliminary evidence for future R01-level projects, or developing and refining conceptual models that link alcohol-related factors to HIV outcomes. Projects can reasonably span multiple research domains, including behavioral science, clinical research, prevention science, implementation or health services research, and biologically oriented studies, as long as the focus remains on the intersection of alcohol and HIV/AIDS.

The opportunity is categorized as discretionary funding and is offered as a grant within the NIH health funding area, associated with CFDA number 93.273 (Alcohol Research Programs). Cost sharing or matching is not required, which is consistent with many NIH mechanisms and reduces barriers for applicants that may not have discretionary funds to contribute. The FOA lists multiple receipt dates rather than a single deadline, meaning applicants could submit on standard NIH cycle dates during the active period of the announcement, as specified in the full announcement.

Eligibility is broad and includes a wide range of organizational types. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, and multiple levels of government organizations (state, county, city/township, special district). It also includes Native American tribal governments (federally recognized) and tribal organizations (not federally recognized), as well as public housing authorities and independent school districts. The FOA explicitly notes that foreign institutions are eligible to apply, that eligible federal agencies may apply, and that faith-based and community-based organizations are eligible, reflecting an intent to encourage diverse applicants with access to different populations, settings, and research capabilities.

Administrative details show the FOA was posted on November 20, 2006, with an archive date of February 2, 2010, indicating it is no longer active as a current competition, but remains available as a record. The official full announcement is linked through NIH at http://grants.nih.gov/grants/guide/pa-files/PA-07-063.html. For access or technical issues related to the announcement, the contact provided is the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV), which is a general support contact for difficulties retrieving or linking to the funding notice.

Overall, this FOA is best understood as NIAAA's targeted invitation for early-stage, creative research that tightens the evidence base around how alcohol and alcohol-related contexts influence HIV transmission risk, clinical outcomes, and the effectiveness of prevention and treatment strategies, with the goal of improving HIV/AIDS prevention, care, and control by addressing alcohol as a significant and modifiable factor.

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