Opportunity Information: Apply for PA 10 160

  • The National Institutes of Health in the education environment health income security and social services sector is offering a public funding opportunity titled "Research on Autism and Autism Spectrum Disorders (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.173 Research Related to Deafness and Communication Disorders 93.242 Mental Health Research Grants 93.361 Nursing Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on May 1, 2013 and posted on Mar 30, 2010.
  • Applicants must submit their applications by May 1, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) State governments City or township governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Small businesses Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments For profit organizations other than small businesses Special district governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The National Institutes of Health (NIH) grant opportunity titled "Research on Autism and Autism Spectrum Disorders (R21)" (Funding Opportunity Number PA-10-160) supports exploratory research aimed at improving understanding and outcomes related to autism spectrum disorders (ASD). The core intent is to fund studies that clarify the causes and development of ASD (etiology), how ASD occurs and is distributed across populations (epidemiology), how ASD is identified and measured (diagnosis), what approaches improve symptoms and functioning (treatment), and how services can be delivered more effectively in real-world settings (service delivery). The announcement explicitly welcomes a wide range of approaches, including basic science, clinical research, and applied or community-facing studies, with the overall scope aligned to the goals laid out in the Interagency Autism Coordinating Committee (IACC) Strategic Plan for ASD Research.

This opportunity uses the NIH R21 mechanism, which is designed for early-stage, developmental, or highly innovative projects where the work may be more speculative than a typical full-scale research project. The expectation is that R21 projects can be higher risk but potentially high reward, meaning they may test new ideas, generate preliminary data, develop novel tools or methodologies, build or validate models, or open up new lines of inquiry that could later justify larger studies. In practical terms, an R21 is meant to help investigators explore promising concepts that are not yet mature enough for a longer, more resource-intensive grant, but that could produce a major payoff if the approach works.

The FOA runs in parallel with two related announcements that share the same scientific scope but use different NIH grant mechanisms: PA-10-158 for the R01 mechanism (typically used for more fully developed and comprehensive projects) and PA-10-159 for the R03 mechanism (often used for small, short-term projects). Applicants who are deciding between mechanisms would generally look at whether their proposed work is best framed as exploratory development (R21), a small pilot with limited aims (R03), or a more complete and definitive research plan (R01).

Funding under this announcement is not guaranteed; awards depend on the availability of federal funds and on whether enough high-quality, competitive applications are submitted. The listed award ceiling is $200,000. There is no cost sharing or matching requirement, which means applicants are not required to contribute non-federal funds as a condition of the award.

Eligibility is broad and includes many types of organizations. Eligible applicants include public and private institutions of higher education, nonprofits (both with and without 501(c)(3) status), small businesses, other for-profit organizations (excluding small businesses in that specific category), independent school districts, and multiple levels of government (state, county, city or township, special district governments, and certain housing authorities). The eligibility language also extends to a range of specific institution types and communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, tribal governments and tribal organizations, faith-based and community-based organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations) and regional organizations. The announcement notes that some eligibility details are clarified in the full FOA text.

Administratively, this is a discretionary grant program categorized under multiple federal activity areas (including education, environment, health, income security, and social services) and mapped to several CFDA numbers that reflect NIH institutes and research domains relevant to ASD, such as mental health, child health and human development, neuroscience and neurological disorders, nursing research, communication disorders, and environmental health. The original posting date is March 30, 2010, with later record dates reflecting the lifecycle of the announcement in the federal listings; the announcement is archived as of June 1, 2013, and the listed closing dates fall in 2013. The administering agency is NIH, and the full announcement was available through the NIH grants policy/guide site at the link provided in the source information. For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster.

Frequently Asked Questions (FAQs)

What is the title and funding opportunity number for this NIH grant?

The opportunity is titled "Research on Autism and Autism Spectrum Disorders (R21)" and the Funding Opportunity Number is PA-10-160.

What is the main purpose of PA-10-160?

This NIH opportunity supports exploratory research intended to improve understanding and outcomes related to autism spectrum disorders (ASD). The scope includes studies focused on ASD causes and development (etiology), how ASD occurs across populations (epidemiology), how ASD is identified and measured (diagnosis), approaches that improve symptoms and functioning (treatment), and improving how services are delivered in real-world settings (service delivery).

What kinds of research approaches are encouraged under this announcement?

The announcement welcomes a wide range of approaches, including basic science, clinical research, and applied or community-facing studies, as long as they align with the overall scientific scope described in the opportunity.

How does this opportunity relate to the IACC Strategic Plan?

The overall scope is aligned to the goals laid out in the Interagency Autism Coordinating Committee (IACC) Strategic Plan for ASD Research.

What NIH grant mechanism is used for this opportunity?

This opportunity uses the NIH R21 mechanism.

What is an R21 and what type of projects is it meant to support?

The R21 mechanism is designed for early-stage, developmental, or highly innovative projects. It is intended for exploratory work that may be more speculative than a typical full-scale project and may involve higher risk but potentially high reward.

What are examples of the kinds of outcomes an R21 project might aim for?

Based on the description in this announcement, an R21 may be used to test new ideas, generate preliminary data, develop novel tools or methodologies, build or validate models, or open new lines of inquiry that could later support a larger study.

Is funding guaranteed if an application is submitted?

No. Awards are not guaranteed and depend on the availability of federal funds and whether a sufficient number of high-quality, competitive applications are submitted.

What is the maximum award amount mentioned for this opportunity?

The listed award ceiling is $200,000.

Is cost sharing or matching required?

No. There is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of the award.

Are there related NIH autism research announcements with other mechanisms?

Yes. This FOA runs in parallel with two related announcements that share the same scientific scope but use different mechanisms: PA-10-158 (R01) and PA-10-159 (R03).

How should an applicant think about choosing between R21, R03, and R01 for the same scientific scope?

The description suggests selecting a mechanism based on the maturity and scale of the proposed work: R21 for exploratory development, R03 for a small, short-term project with limited aims, and R01 for a more fully developed and comprehensive research plan.

Who is eligible to apply?

Eligibility is broad and includes many types of organizations, including public and private institutions of higher education, nonprofits (with and without 501(c)(3) status), small businesses, other for-profit organizations (excluding small businesses in that specific category), independent school districts, and multiple levels of government (such as state, county, city or township, special district governments, and certain housing authorities).

Do specific institution types and communities have eligibility mentioned explicitly?

Yes. The eligibility language extends to specific institution types and communities, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, tribal governments and tribal organizations, faith-based and community-based organizations, and U.S. territories or possessions.

Are non-U.S. organizations allowed to apply?

Yes. The opportunity includes non-U.S. entities (foreign organizations) and regional organizations in the eligibility language, with a note that some eligibility details are clarified in the full FOA text.

What federal agency administers this grant opportunity?

The administering agency is the National Institutes of Health (NIH).

What type of grant program is this described as?

It is described as a discretionary grant program.

How is this opportunity categorized in federal activity areas?

The announcement is categorized under multiple federal activity areas, including education, environment, health, income security, and social services.

What CFDA areas are associated with this opportunity?

The listing references several CFDA numbers reflecting NIH institutes and research domains relevant to ASD, including areas such as mental health, child health and human development, neuroscience and neurological disorders, nursing research, communication disorders, and environmental health.

When was this opportunity originally posted, and what is its current status?

The original posting date is March 30, 2010. The announcement is archived as of June 1, 2013, and the listed closing dates fall in 2013.

Where was the full announcement available?

The full announcement was available through the NIH grants policy/guide website at the link provided in the source information.

Who is listed as a contact for access or technical issues?

For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster.

Does the summary indicate that the full FOA contains additional details?

Yes. The announcement notes that some eligibility details are clarified in the full FOA text.

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