Opportunity Information: Apply for PA 14 244
Apply for PA 14 244
- The National Institutes of Health in the education food and nutrition health income security and social services sector is offering a public funding opportunity titled "Research on Chronic Overlapping Pain Conditions (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.213 Research and Training in Complementary and Integrative Health 93.273 Alcohol Research Programs 93.313 NIH Office of Research on Womens Health 93.361 Nursing Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jun 4, 2014 and posted on Jun 3, 2014.
- Applicants must submit their applications by Sep 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public housing authorities/Indian housing authorities Independent school districts For profit organizations other than small businesses Special district governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education County governments Others (see text field entitled Additional Information on Eligibility for clarification) State governments City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
Research on Chronic Overlapping Pain Conditions (R01) is a National Institutes of Health (NIH) Funding Opportunity Announcement designed to support research that clarifies why many people do not experience chronic pain as a single, isolated diagnosis, but instead live with multiple chronic pain conditions that overlap, co-occur, or evolve over time. The FOA focuses on chronic overlapping pain conditions, meaning situations where a person diagnosed with one chronic pain disorder often shows signs of additional pain conditions or later shifts into a different diagnostic category. The central aim is to strengthen the evidence base on how common these overlaps are, what drives them biologically and psychologically, how they progress across time, and what clinical approaches work best when pain conditions cluster rather than appearing alone.
The opportunity encourages epidemiological, clinical, and translational research. Epidemiological projects might quantify prevalence, incidence, and patterns of comorbidity across populations and subgroups. Clinical research is expected to address patient-level factors, including clinical risk factors and symptom trajectories, while translational studies are meant to connect clinical observations back to underlying mechanisms, such as neurobiological pathways, immune or endocrine contributions, genetic and epigenetic factors, and other biological processes that could explain shared vulnerability across conditions. The FOA also explicitly calls for attention to psychological variables, reflecting the reality that mood, stress, trauma history, cognition, coping, and related behavioral factors may shape both the development of pain overlaps and the way these conditions persist or worsen.
A major emphasis is building research groups that bridge complementary expertise. NIH signals that progress in this area depends on teams that can integrate knowledge of pain mechanisms with real-world clinical and translational experience. Applicants are encouraged to create collaborations that cut across disciplines, and to bring in researchers from outside the traditional pain field when their perspectives could expand the science, such as experts in epidemiology, women’s health, neuroscience, immunology, endocrinology, psychiatry, behavioral science, biostatistics, or data science. The FOA also encourages applicants to leverage existing resources (for example, established cohorts, registries, biobanks, electronic health record datasets, or ongoing clinical studies) and, when needed, to develop new resources that will enable more rigorous study of overlapping pain conditions over time.
Administratively, this is an R01 grant mechanism under NIH’s discretionary grant authority, supporting full research projects rather than small pilot efforts. The Funding Opportunity Number is PA-14-244, posted June 3, 2014 (created June 4, 2014). The original and final closing date listed is September 7, 2017, with an archive date of October 8, 2017, meaning this specific announcement has closed and is kept for historical reference, though similar NIH pain-related FOAs may exist under newer numbers.
Eligibility is broad and reflects NIH’s typical openness to a wide range of research institutions and organizational types. Eligible applicants include public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and certain non-501(c)(3) entities), small businesses, for-profit organizations other than small businesses, and multiple levels of government (state, county, city/township, special district). The FOA also lists eligibility for tribal governments and tribal organizations, public housing authorities/Indian housing authorities, independent school districts, and a variety of mission-specific institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It further notes that non-U.S. entities (foreign organizations), U.S. territories or possessions, regional organizations, and faith-based or community-based organizations may be eligible, along with eligible federal agencies. No cost sharing or matching requirement is indicated.
The FOA is associated with multiple CFDA numbers, reflecting participation or relevance across several NIH institutes and programs, including oral health, complementary and integrative health, alcohol research programs, women’s health, nursing research, musculoskeletal and skin diseases, diabetes/digestive/kidney research, neuroscience and neurological disorders, and child health and human development. This cross-cutting footprint underscores the idea that overlapping chronic pain conditions are not confined to one body system or one clinical specialty, and that progress will likely come from research that integrates across traditional boundaries.
For those seeking the original announcement details, NIH provided an Additional Information link to the NIH grants guide page (http://grants.nih.gov/grants/guide/pa-files/PA-14-244.html). NIH also listed contact help through the NIH Office of Extramural Research (OER) webmaster for access or linking issues (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the title of this NIH funding opportunity?
The opportunity is titled Research on Chronic Overlapping Pain Conditions (R01).
What is the Funding Opportunity Number?
The Funding Opportunity Number is PA-14-244.
Which agency is offering this opportunity?
This is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA).
What does the FOA mean by "chronic overlapping pain conditions"?
In this FOA, chronic overlapping pain conditions refer to situations where a person diagnosed with one chronic pain disorder often has signs of additional pain conditions that overlap or co-occur, or where their condition evolves over time and may shift into a different diagnostic category. The focus is on chronic pain that does not appear as a single isolated diagnosis, but as conditions that cluster or change over time.
What is the main purpose of the FOA?
The central aim is to strengthen the evidence base on how common overlapping chronic pain conditions are, what drives them biologically and psychologically, how they progress across time, and what clinical approaches work best when pain conditions cluster rather than appearing alone.
What kinds of research does this FOA encourage?
The FOA encourages epidemiological, clinical, and translational research focused on chronic overlapping pain conditions.
What types of questions are epidemiological studies expected to address?
Epidemiological projects might quantify prevalence, incidence, and patterns of comorbidity across populations and subgroups.
What types of questions are clinical studies expected to address?
Clinical research is expected to address patient-level factors, including clinical risk factors and symptom trajectories over time.
What does the FOA mean by translational research in this context?
Translational studies are intended to connect clinical observations back to underlying mechanisms, such as neurobiological pathways, immune or endocrine contributions, genetic and epigenetic factors, and other biological processes that could explain shared vulnerability across pain conditions.
Does the FOA emphasize psychological or behavioral factors?
Yes. The FOA explicitly calls for attention to psychological variables, reflecting that factors like mood, stress, trauma history, cognition, and coping may influence how overlapping pain conditions develop and how they persist or worsen.
Is team science or cross-disciplinary collaboration encouraged?
Yes. A major emphasis is building research groups that bridge complementary expertise. NIH signals that progress depends on teams that integrate knowledge of pain mechanisms with real-world clinical and translational experience, including collaborations that cut across disciplines.
Are applicants encouraged to include experts outside traditional pain research?
Yes. The FOA encourages bringing in researchers from outside the traditional pain field when their perspectives could expand the science, including expertise such as epidemiology, women's health, neuroscience, immunology, endocrinology, psychiatry, behavioral science, biostatistics, or data science.
Does the FOA encourage using existing datasets or research resources?
Yes. Applicants are encouraged to leverage existing resources such as established cohorts, registries, biobanks, electronic health record (EHR) datasets, or ongoing clinical studies.
Can applicants propose developing new resources for this research area?
Yes. The FOA notes that, when needed, applicants may develop new resources that enable more rigorous study of overlapping pain conditions over time.
What grant mechanism is used for this opportunity?
This FOA uses the R01 grant mechanism, intended to support full research projects rather than small pilot efforts.
Is cost sharing or matching required?
No cost sharing or matching requirement is indicated in the information provided.
When was this FOA posted and created?
The FOA was posted on June 3, 2014 and created on June 4, 2014.
Is this funding opportunity still open?
No. The original and final closing date listed is September 7, 2017, and the archive date is October 8, 2017. This specific announcement has closed and is maintained for historical reference.
Does the FOA suggest that similar opportunities may exist?
Yes. While this specific FOA is closed, the description notes that similar NIH pain-related FOAs may exist under newer funding opportunity numbers.
Who is eligible to apply?
Eligibility is broad and includes many organization types, including public and private institutions of higher education; nonprofit organizations (both 501(c)(3) and certain non-501(c)(3) entities); small businesses; for-profit organizations other than small businesses; and multiple levels of government (state, county, city/township, and special district).
Are tribal governments and tribal organizations eligible?
Yes. The FOA lists eligibility for tribal governments and tribal organizations.
Are public housing authorities eligible?
Yes. The FOA includes public housing authorities/Indian housing authorities as eligible applicants.
Are independent school districts eligible?
Yes. Independent school districts are listed among eligible applicants.
Are minority-serving institutions specifically included?
Yes. The FOA explicitly includes several mission-specific institution types, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are foreign organizations or non-U.S. entities eligible?
Yes. The FOA notes that non-U.S. entities (foreign organizations) may be eligible.
Are U.S. territories or possessions included?
Yes. The FOA notes eligibility may include U.S. territories or possessions.
Are faith-based or community-based organizations eligible?
Yes. The FOA states that faith-based or community-based organizations may be eligible.
Are federal agencies eligible to apply?
Yes. The FOA indicates that eligible federal agencies may apply.
Why are multiple CFDA numbers associated with this FOA?
The FOA is associated with multiple CFDA numbers reflecting participation or relevance across several NIH institutes and programs (including areas such as oral health, complementary and integrative health, alcohol research, women's health, nursing research, musculoskeletal and skin diseases, diabetes/digestive/kidney research, neuroscience and neurological disorders, and child health and human development). This underscores that overlapping chronic pain conditions cut across body systems and clinical specialties.
Where can someone find the original NIH announcement page?
NIH provided an Additional Information link to the NIH grants guide page: http://grants.nih.gov/grants/guide/pa-files/PA-14-244.html.
Who should be contacted for access or linking issues related to the NIH page?
NIH listed contact help through the NIH Office of Extramural Research (OER) webmaster: FBOWebmaster@OD.NIH.GOV.
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