Opportunity Information: Apply for PA 06 368
Apply for PA 06 368
- The National Institutes of Health in the education environment food and nutrition health income security and social services sector is offering a public funding opportunity titled "Research On Ethical Issues In Human Subjects Research (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.361 Nursing Research 93.395 Cancer Treatment Research 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.855 Allergy, Immunology and Transplantation Research 93.856 Microbiology and Infectious Diseases Research 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.989 International Research and Research Training.
- This funding opportunity was created on Apr 26, 2010 and posted on Apr 26, 2006.
- Applicants must submit their applications by May 7, 2011 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education Public and State controlled institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Independent school districts Public housing authorities/Indian housing authorities County governments.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity PA 06 368, titled "Research On Ethical Issues In Human Subjects Research (R21)," supports exploratory and developmental studies that investigate ethical issues arising in research involving human participants. The central goal is to generate early stage evidence, concepts, and practical approaches that can improve the ethical design and conduct of human subjects research across many biomedical, behavioral, and social science settings. Because it uses the R21 mechanism, the emphasis is on innovative, preliminary, and potentially high-impact projects that may be at an earlier stage than what would typically be expected for a larger, longer R01 study.
This announcement uses the NIH Exploratory/Developmental Research Grant (R21) mechanism and is described as running in parallel with companion announcements that have the same scientific scope but different grant mechanisms (PA 06 369 for R01 and PA 06 367 for R03). In practice, that means applicants should choose the mechanism that best fits the maturity, scale, and resource needs of their proposed work. NIH notes that project size and duration can vary by application, but the R21 under this FOA is capped at a two-year project period.
Budget limits are clearly defined. Direct costs may not exceed $275,000 total across the two-year R21 period, and no more than $200,000 in direct costs may be requested in any single year. The opportunity does not require cost sharing or matching. Although the listing includes an "award ceiling" figure of $200,000, the text clarifies that the $200,000 figure applies as a per-year cap, with the overall two-year direct cost cap set at $275,000.
Eligibility is broad and includes a wide range of domestic and international organizations. Eligible applicants include for-profit and non-profit organizations; public or private institutions such as universities, colleges, hospitals, and laboratories; units of state and local government; eligible federal agencies; and faith-based or community-based organizations. Tribal entities are also eligible, including federally recognized tribes, non-federally recognized tribal governments, and tribally designated organizations. The opportunity explicitly states that foreign institutions are eligible to apply, which can be important for ethics research that addresses global or cross-border human subjects issues.
The opportunity is open to any qualified Project Director/Principal Investigator (PD/PI) with the skills, knowledge, and resources to conduct the proposed research, working through an eligible institution. NIH also reiterates its long-standing encouragement for applications from individuals from underrepresented racial and ethnic groups and from individuals with disabilities. Applicants may submit more than one application as long as each proposed project is scientifically distinct, which allows a single investigator or institution to pursue multiple ethics questions without forcing them into a single, overly broad proposal.
From an administrative and review-routing standpoint, NIH indicates that applications will be assigned to NIH Institutes and Centers (ICs) using standard Public Health Service referral guidelines and specific IC program interests. The CFDA program numbers listed span a wide set of NIH mission areas, reflecting that ethical issues in human subjects research cut across disease areas and research domains, including but not limited to cancer, mental health, addiction, aging, infectious disease, child health, neurological disorders, cardiovascular and lung diseases, diabetes and kidney diseases, and international research and training.
Timing information in the source details indicates that the announcement was posted on April 26, 2006, and later archived (with an archive date of June 7, 2011). The original and current closing language references multiple receipt dates, meaning applications were accepted on standard NIH submission cycles during the active period of the FOA, with applicants directed to the full announcement for the exact due dates and instructions. The full FOA text is linked through the NIH Grants Guide (PA 06 368), and NIH provides contact information through the NIH Office of Extramural Research (OER) for access or technical linking issues.
Overall, this R21 opportunity is designed for short, focused projects that can quickly test ideas, develop methods, collect pilot data, or explore emerging ethical challenges in human subjects research, with flexible topic fit across NIH program areas, broad organizational eligibility (including foreign institutions), and defined two-year and budget limits consistent with the R21 mechanism.
FAQs: NIH PA-06-368 - Research on Ethical Issues in Human Subjects Research (R21)
What is PA-06-368?
PA-06-368 is a National Institutes of Health (NIH) funding opportunity titled "Research On Ethical Issues In Human Subjects Research (R21)." It supports exploratory and developmental research that examines ethical issues that arise in studies involving human participants.
What is the main purpose of this funding opportunity?
The central goal is to generate early-stage evidence, concepts, and practical approaches that can improve the ethical design and conduct of human subjects research across biomedical, behavioral, and social science settings.
What grant mechanism does PA-06-368 use?
This opportunity uses the NIH Exploratory/Developmental Research Grant (R21) mechanism.
Why does the R21 mechanism matter for project design?
Because this is an R21, NIH emphasizes innovative, preliminary, and potentially high-impact projects. The expectation is that projects may be at an earlier stage than what would typically be expected for a larger and longer R01 study.
How long can an R21 project last under this announcement?
The R21 project period under this FOA is capped at two years.
What are the budget limits for this R21?
Direct costs may not exceed $275,000 total across the two-year project period, and no more than $200,000 in direct costs may be requested in any single year.
Is there an overall award ceiling and how should it be interpreted?
The listing includes an "award ceiling" figure of $200,000, and the FOA text clarifies that $200,000 is a per-year direct cost cap, while the overall two-year direct cost cap is $275,000.
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching.
What kinds of research topics fit this FOA?
Projects should investigate ethical issues arising in research involving human participants and aim to improve ethical design and conduct. The topic fit is flexible across many biomedical, behavioral, and social science research settings.
What kinds of projects are especially well-suited to this opportunity?
This FOA is designed for short, focused studies that can quickly test ideas, develop methods, collect pilot data, or explore emerging ethical challenges in human subjects research.
Are there companion opportunities with the same scope?
Yes. NIH describes PA-06-368 as running in parallel with companion announcements that share the same scientific scope but use different grant mechanisms: PA-06-369 (R01) and PA-06-367 (R03).
How do applicants choose between the R21, R01, and R03 companion announcements?
Applicants should choose the mechanism that best fits the maturity, scale, and resource needs of the proposed work. The R21 is positioned for exploratory and developmental research compared to larger R01 projects and smaller R03 projects.
Who is eligible to apply as an organization?
Eligibility is broad and includes domestic and international organizations. Eligible applicants include for-profit and non-profit organizations; public or private institutions (such as universities, colleges, hospitals, and laboratories); units of state and local government; eligible federal agencies; and faith-based or community-based organizations.
Are tribal entities eligible to apply?
Yes. Tribal entities are eligible, including federally recognized tribes, non-federally recognized tribal governments, and tribally designated organizations.
Are foreign institutions eligible to apply?
Yes. The opportunity explicitly states that foreign institutions are eligible to apply, which is relevant for ethics research that addresses global or cross-border human subjects issues.
Who can serve as the Project Director/Principal Investigator (PD/PI)?
Any qualified PD/PI with the skills, knowledge, and resources to carry out the proposed research may apply through an eligible institution.
Does NIH encourage applications from specific groups of investigators?
Yes. NIH reiterates encouragement for applications from individuals from underrepresented racial and ethnic groups and from individuals with disabilities.
Can an investigator or institution submit more than one application?
Yes. Applicants may submit more than one application as long as each proposed project is scientifically distinct.
How will applications be assigned within NIH?
NIH indicates that applications will be assigned to NIH Institutes and Centers (ICs) using standard Public Health Service referral guidelines and specific IC program interests.
Which NIH program areas are connected to this FOA?
The CFDA program numbers listed span a wide range of NIH mission areas, reflecting that ethical issues in human subjects research cut across many disease areas and research domains (including areas such as cancer, mental health, addiction, aging, infectious disease, child health, neurological disorders, cardiovascular and lung diseases, diabetes and kidney diseases, and international research and training).
When was this funding opportunity posted, and what is its current status?
The announcement was posted on April 26, 2006, and it was later archived with an archive date of June 7, 2011.
Were there specific application due dates?
The closing language references multiple receipt dates, meaning applications were accepted on standard NIH submission cycles during the active period of the FOA. Applicants were directed to the full announcement for exact due dates and instructions.
Where can applicants find the full FOA text?
The full FOA text is linked through the NIH Grants Guide as PA-06-368.
Who should be contacted for access or technical link issues?
NIH provides contact information through the NIH Office of Extramural Research (OER) for access or technical linking issues.
Browse more opportunities from the same category: Education Environment Food and Nutrition Health Income Security and Social Services
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| Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R01) Apply for PAR 07 379 Funding Number: PAR 07 379 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Enhancing Zebrafish Research with Research Tools and Techniques (R01) Apply for PAR 08 139 Funding Number: PAR 08 139 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships (F31) to Promote Diversity in Health Related Research Apply for PA 07 106 Funding Number: PA 07 106 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (F32) Apply for PA 07 107 Funding Number: PA 07 107 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellows (F33) Apply for PA 07 172 Funding Number: PA 07 172 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2009 02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR R43/R44) Apply for PA 09 080 Funding Number: PA 09 080 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: $100,000 |
| PHS 2009 02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR R41/R42) Apply for PA 09 081 Funding Number: PA 09 081 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: $100,000 |
| NIH Support for Conferences and Scientific Meetings (Parent R13/U13) Apply for PA 08 149 Funding Number: PA 08 149 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships (F31) to Promote Diversity in Health Related Research Apply for PA 09 209 Funding Number: PA 09 209 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (F32) Apply for PA 09 210 Funding Number: PA 09 210 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Research Project Grant (Parent R01) Apply for PA 10 067 Funding Number: PA 10 067 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Academic Research Enhancement Award (Parent R15) Apply for PA 10 070 Funding Number: PA 10 070 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| NIH Support for Conferences and Scientific Meetings (Parent R13/U13) Apply for PA 10 071 Funding Number: PA 10 071 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2010 02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR R43/R44) Apply for PA 10 050 Funding Number: PA 10 050 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2010 02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR R41/R42) Apply for PA 10 051 Funding Number: PA 10 051 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships to Promote Diversity in Health Related Research (Parent F31 Diversity) Apply for PA 10 109 Funding Number: PA 10 109 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (Parent F32) Apply for PA 10 110 Funding Number: PA 10 110 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Understanding and Promoting Health Literacy (R01) Apply for PAR 10 133 Funding Number: PAR 10 133 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R01) Apply for PAR 10 136 Funding Number: PAR 10 136 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
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