Opportunity Information: Apply for PA 13 378
Apply for PA 13 378
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Research on Malignancies in the Context of HIV/AIDS (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.393 Cancer Cause and Prevention Research.
- This funding opportunity was created on Oct 21, 2013 and posted on Oct 21, 2013.
- Applicants must submit their applications by Sep 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments Public and State controlled institutions of higher education For profit organizations other than small businesses Independent school districts Small businesses Special district governments Private institutions of higher education City or township governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity PA 13-378, titled "Research on Malignancies in the Context of HIV/AIDS (R21)," supports exploratory and developmental research projects that aim to deepen what is known about cancers occurring in people living with HIV or AIDS. The focus is on improving understanding of how these malignancies arise, how they progress, how best to diagnose them, and how to treat them effectively in the context of HIV-related immune dysfunction. The announcement is aimed at studies that can clarify why cancer risks and outcomes differ in HIV-infected populations and how HIV itself, along with co-infections and other contributing factors, shapes cancer biology and clinical course. The longer-term goal is to generate evidence that can directly inform better screening strategies and more effective, tailored therapies for HIV-infected individuals.
A major emphasis of the FOA is on malignancies that are either AIDS-defining or non-AIDS-defining, reflecting the broad cancer burden seen in HIV, especially in the era of antiretroviral therapy. The NIH, through the National Cancer Institute (NCI) and the National Institute of Dental and Craniofacial Research (NIDCR), encourages applications that examine etiologic factors and cofactors (for example, viral co-infections and other exposures that may interact with HIV), immunopathogenesis (how altered immunity contributes to tumor initiation and progression), diagnostic approaches, and the consequences of these cancers across diverse populations. Projects are expected to help disentangle what is specifically driven by HIV infection versus what is driven by other pathogens, host factors, treatment effects, or social and environmental determinants, with an eye toward translating those insights into better prevention and care.
This is an R21 mechanism, which generally signals support for early-stage, high-impact, or proof-of-concept work that can open up new directions or generate key preliminary data for larger future studies. The listed award ceiling is $200,000, and the program does not require cost sharing or matching. The opportunity falls under discretionary grant funding and is categorized within education and health-related activities, with CFDA numbers 93.393 (Cancer Cause and Prevention Research) and 93.121 (Oral Diseases and Disorders Research), reflecting the involvement of both NCI and NIDCR and the relevance to cancer prevention as well as oral and craniofacial disease contexts where applicable.
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants include state, county, city, and special district governments; public and private institutions of higher education; nonprofit organizations (including those with and without 501(c)(3) status, except as limited by NIH policy); for-profit organizations (including small businesses); independent school districts; public housing authorities/Indian housing authorities; and Native American tribal governments and tribal organizations. The FOA also explicitly includes a wide range of mission-focused institutions and community-rooted entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations. Foreign organizations and foreign institutions are eligible to apply, non-U.S. components of U.S. organizations are allowed, and foreign components (as defined in NIH policy) are permitted, which makes this opportunity accessible to international teams studying HIV-associated malignancies in settings where HIV burden may be high.
Key dates in the source record indicate the FOA was posted and created on October 21, 2013, with an original and current closing date of September 7, 2016, and an archive date of October 8, 2016. The sponsoring agency is the National Institutes of Health. For full details, applicants were directed to the official NIH Grants Guide posting (http://grants.nih.gov/grants/guide/pa-files/PA-13-378.html). For technical issues accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the NIH funding opportunity PA-13-378?
PA-13-378 is an NIH funding opportunity titled "Research on Malignancies in the Context of HIV/AIDS (R21)." It supports exploratory and developmental research projects focused on cancers that occur in people living with HIV or AIDS.
What is the main purpose of this FOA?
The purpose is to deepen understanding of how malignancies arise, progress, are best diagnosed, and can be treated effectively in the context of HIV-related immune dysfunction, with the longer-term goal of informing better screening strategies and more tailored therapies for HIV-infected individuals.
What types of research does this FOA support?
The FOA supports exploratory and developmental studies that can clarify why cancer risks and outcomes differ in HIV-infected populations and how HIV, co-infections, and other contributing factors shape cancer biology and the clinical course of disease.
Which cancers are emphasized under this opportunity?
A major emphasis is on both AIDS-defining malignancies and non-AIDS-defining malignancies, reflecting the broad cancer burden seen in HIV, particularly in the era of antiretroviral therapy.
Does the FOA focus on prevention, diagnosis, and treatment, or only one of these areas?
It spans multiple points along the research-to-care continuum, including etiologic research (how cancers arise), immunopathogenesis (how altered immunity contributes), diagnostic approaches, and strategies that can inform better prevention and treatment in HIV-infected populations.
What kinds of contributing factors does NIH want applicants to examine?
NIH encourages applications that examine etiologic factors and cofactors, including viral co-infections and other exposures that may interact with HIV, as well as host factors, treatment effects, and social and environmental determinants that may influence cancer risk and outcomes.
What does the FOA mean by immunopathogenesis in the context of HIV-associated malignancies?
In this FOA, immunopathogenesis refers to how altered immune function related to HIV infection may contribute to tumor initiation and progression, and how HIV-related immune dysfunction influences cancer biology and disease course.
Is the FOA interested in studies that separate the effects of HIV from other causes?
Yes. Projects are expected to help disentangle what is specifically driven by HIV infection versus what is driven by other pathogens, host characteristics, treatment effects, or social and environmental determinants.
What is the funding mechanism used in PA-13-378?
This opportunity uses the NIH R21 mechanism, which generally supports early-stage, high-impact, proof-of-concept, or exploratory/developmental work intended to open new directions or generate key preliminary data for larger future studies.
What is the maximum award amount mentioned for this R21?
The listed award ceiling is $200,000.
Is cost sharing or matching required?
No. The program does not require cost sharing or matching.
Which NIH institutes are involved in sponsoring or encouraging applications under this FOA?
The National Cancer Institute (NCI) and the National Institute of Dental and Craniofacial Research (NIDCR) are specifically noted as encouraging applications, and the sponsoring agency is the National Institutes of Health (NIH).
What CFDA numbers are associated with this grant opportunity?
The opportunity lists CFDA numbers 93.393 (Cancer Cause and Prevention Research) and 93.121 (Oral Diseases and Disorders Research).
How is this opportunity categorized in the source record?
It is described as discretionary grant funding and categorized within education and health-related activities.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. and non-U.S. organizations, including various levels of government, higher education institutions, nonprofit and for-profit organizations (including small businesses), independent school districts, housing authorities, and tribal governments and tribal organizations.
Are nonprofits eligible even if they do not have 501(c)(3) status?
The FOA states that nonprofit organizations are eligible, including those with and without 501(c)(3) status, except as limited by NIH policy.
Are for-profit organizations eligible to apply?
Yes. For-profit organizations (including small businesses) are listed as eligible applicants.
Are tribal governments and tribal organizations eligible?
Yes. Native American tribal governments and tribal organizations are listed as eligible.
Does the FOA explicitly encourage applications from mission-focused or community-rooted institutions?
Yes. The FOA explicitly includes institutions and entities such as HBCUs, Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, and also faith-based and community-based organizations.
Can non-U.S. (foreign) organizations apply?
Yes. Foreign organizations and foreign institutions are eligible to apply.
Are non-U.S. components of U.S. organizations allowed?
Yes. Non-U.S. components of U.S. organizations are allowed.
Are foreign components permitted under NIH policy for this FOA?
Yes. The FOA states that foreign components (as defined in NIH policy) are permitted.
What are the key dates listed for this opportunity?
The source record indicates the FOA was posted and created on October 21, 2013. The original and current closing date is September 7, 2016, and the archive date is October 8, 2016.
Where can applicants find the official announcement?
Applicants were directed to the NIH Grants Guide posting at http://grants.nih.gov/grants/guide/pa-files/PA-13-378.html.
Who should be contacted for technical issues accessing the announcement?
For technical issues accessing the announcement, the listed contact is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 13 378) also looked into and applied for these:
| Funding Opportunity |
|---|
| Research on Malignancies in the Context of HIV/AIDS (R01) Apply for PA 13 377 Funding Number: PA 13 377 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Sub Saharan African Collaborative HIV and Cancer Consortia (U54) Apply for RFA CA 13 010 Funding Number: RFA CA 13 010 Agency: National Institutes of Health Category: Education Health Funding Amount: $750,000 |
| FY 2014 American Schools and Hospitals Abroad (ASHA) Program Apply for APS ASHA 14 000001 Funding Number: APS ASHA 14 000001 Agency: Agency for International Development Category: Education Health Funding Amount: $2,000,000 |
| Cancer Detection, Diagnostic and Treatment Technologies for Global Health (UH2/UH3) Apply for RFA CA 13 015 Funding Number: RFA CA 13 015 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Population based Research Optimizing Screening through Personalized Regimens (PROSPR) Revision to Enhance the Collection of Cervical Cancer Screening Data (U54) Apply for RFA CA 14 001 Funding Number: RFA CA 14 001 Agency: National Institutes of Health Category: Education Health Funding Amount: $650,000 |
| Cancer Center Support Grants (CCSGs) for NCI designated Cancer Centers (P30) Apply for PAR 13 386 Funding Number: PAR 13 386 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Low Cost, Pragmatic, Patient Centered Randomized Controlled Intervention Trials (UH2/UH3) Apply for RFA HL 14 019 Funding Number: RFA HL 14 019 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Development of Opioid and Adjuvant Fixed Combination Dosage Forms for the Treatment of Chronic Pain with Reduced Addiction Potential (R41/R42) Apply for PA 13 388 Funding Number: PA 13 388 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Development of Opioid and Adjuvant Fixed Combination Dosage Forms for the Treatment of Chronic Pain with Reduced Addiction Potential (R43/R44) Apply for PA 13 387 Funding Number: PA 13 387 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NCI Community Oncology Research Program(NCORP) Community Sites (UM1) Apply for RFA CA 13 013 Funding Number: RFA CA 13 013 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NCI Community Oncology Research Program (NCORP) Research Bases (UM1) Apply for RFA CA 13 012 Funding Number: RFA CA 13 012 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NCI Community Oncology Research Program (NCORP) Minority/Underserved Community Sites (UM1) Apply for RFA CA 13 014 Funding Number: RFA CA 13 014 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Exceptional Unconventional Research Enabling Knowledge Acceleration (EUREKA) for Neuroscience and Disorders of the Nervous System (R01) Apply for RFA MH 14 214 Funding Number: RFA MH 14 214 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Indo US Collaborative Program on Affordable Medical Devices (R03) Apply for PAR 13 390 Funding Number: PAR 13 390 Agency: National Institutes of Health Category: Education Health Funding Amount: $75,000 |
| NCI Small Grants Program for Cancer Research (NCI Omnibus R03) Apply for PAR 14 007 Funding Number: PAR 14 007 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Identification of Gene Variants for Addiction Related Traits by Next Gen Sequencing in Model Organisms Selectively Bred for Addiction Traits (UH2/UH3) Apply for PAR 14 010 Funding Number: PAR 14 010 Agency: National Institutes of Health Category: Education Health Funding Amount: $125,000 |
| The Palliative Care Research Cooperative (PCRC) Enhancing Sustainability and Building the Science of Palliative Care (R01) Apply for RFA NR 14 003 Funding Number: RFA NR 14 003 Agency: National Institutes of Health Category: Education Health Funding Amount: $350,000 |
| Revision Applications for Research on Genomic Underpinnings of Response to Rehabilitation Interventions (R01) Apply for PAR 14 012 Funding Number: PAR 14 012 Agency: National Institutes of Health Category: Education Health Funding Amount: $100,000 |
| Genomic Underpinnings of Response to Rehabilitation Interventions (R01) Apply for PAR 14 011 Funding Number: PAR 14 011 Agency: National Institutes of Health Category: Education Health Funding Amount: $350,000 |
| Functional Genetics, Epigenetics, and Non coding RNAs in Substance Abuse (R01) Apply for PA 14 014 Funding Number: PA 14 014 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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