Research on Malignancies in the Context of HIV/AIDS (R21) | Apply Online

Opportunity Summary:

The grant opportunity titled Research on Malignancies in the Context of HIV/AIDS (R21) (Funding Opportunity Number PA 10 291) is a National Institutes of Health discretionary grant announcement led by the National Cancer Institute (NCI) and the National Institute of Dental and Craniofacial Research (NIDCR). It supports exploratory and early-stage research projects using the NIH R21 mechanism, with the overall goal of improving scientific and clinical understanding of cancers that occur in people living with HIV infection or AIDS. The program is framed around the idea that HIV-related immune dysfunction, chronic inflammation, co-infections, and other cofactors can influence cancer risk, cancer biology, and patient outcomes in ways that differ from the general population, and that these differences need targeted research attention.

The FOA specifically encourages applications that advance knowledge about the risks, development, progression, diagnosis, and treatment of malignancies seen in individuals with underlying HIV/AIDS. It is intentionally broad and includes both AIDS-defining malignancies and non-AIDS-defining malignancies, reflecting the evolving cancer landscape in the era of antiretroviral therapy, longer life expectancy, and shifting patterns of cancer incidence among HIV-positive populations. The announcement highlights several priority scientific areas, including etiologic factors and cofactors (for example, behavioral, environmental, genetic, or infectious contributors), immunopathogenesis (how immune alterations related to HIV shape tumor initiation and progression), and the diagnosis and downstream consequences of these cancers across diverse populations. A central emphasis is placed on understanding how HIV itself contributes to cancer development and pathogenesis, including how HIV may interact with other pathogens to promote malignancy.

In terms of expected research outputs, the FOA calls for studies that accomplish two major aims. First, it seeks projects that provide clearer information about clinical outcomes of cancers in HIV-infected populations, which can include survival patterns, treatment response, toxicity profiles, recurrence rates, quality of life impacts, and other real-world outcome measures that may differ due to immune status, comorbidities, or therapy interactions. Second, it promotes research that identifies the specific contributions of HIV infection to cancer development, including mechanistic or translational work that clarifies whether and how HIV-related immunosuppression, immune activation, viral persistence, or treatment-related factors modify cancer risk or tumor behavior. The FOA also explicitly notes interest in pathogen interactions, which often points to co-infections that are known or suspected to play a role in oncogenesis in immunocompromised settings.

The award structure reflects the exploratory nature of an R21. The posted award ceiling is $200,000, and there is no cost sharing or matching requirement. The funding activity is categorized under education and health, and it aligns with multiple CFDA areas spanning oral diseases and disorders research (93.121) and a range of cancer-focused categories including cause and prevention, detection and diagnosis, treatment, and biology (93.393 through 93.396). This signals that the NIH intended to support a wide variety of approaches, from basic and mechanistic cancer biology in the context of HIV, to translational diagnostics, to clinical and population-based studies that clarify prevention and treatment needs.

Eligibility is broad and includes many institution types across the public, private, nonprofit, and for-profit spectrum. Eligible applicants listed include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status (other than institutions of higher education), state and local governments (including city/township, county, special district), independent school districts, small businesses, and for-profit organizations other than small businesses. The FOA also allows participation from Native American tribal governments (federally recognized) and other tribal organizations, public housing authorities and Indian housing authorities, and additional categories such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities, tribally controlled colleges and universities, faith-based or community-based organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations) and regional organizations. This wide eligibility reflects an intent to encourage diverse research settings and populations, which is particularly relevant given the FOA emphasis on malignancies in diverse HIV-affected communities.

Administratively, the opportunity was posted on September 29, 2010, with an original and current closing date of September 7, 2013, and an archive date of October 8, 2013. While it is archived and no longer open, the content provides a clear snapshot of NIH priorities during that period: accelerating targeted research on HIV-associated cancers, improving outcome data for HIV-positive cancer patients, and clarifying biological mechanisms and cofactor interactions that could inform better prevention, diagnostic strategies, and treatment approaches. For full details, the announcement referenced an NIH Guide link (http://grants.nih.gov/grants/guide/pa-files/PA-10-291.html) and provided NIH Office of Extramural Research webmaster contacts for access and technical linking issues.

Browse more business programs for HIV and AIDS support

Browse more opportunities from the same agency: National Institutes of Health

Browse more opportunities from the same category: Education Health

Next opportunity: Urban bird treaty existing cities grant

Previous opportunity: Research on Malignancies in the Context of HIV/AIDS (R01)

USGrants.org Applicant Portal:

Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.

Apply for PA 10 291

 

[Watch] how do funding administrators access proposals?

Applicants also applied for:

Applicants who have applied for this opportunity (PA 10 291) also looked into and applied for these:

 

Grant application guides and resources

It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!

Apply for Grants

 

 

Premium leads for funding administrators, grant writers, and loan issuers

Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.

If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.

Subscribe to Leads

 

Request more information:

Would you like to learn more about this funding opportunity, similar opportunities to "PA 10 291", eligibility, application service, and/or application tips? Submit an inquiry below:

Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.