Research Resource for Human Organs and Tissues (U42) | Apply Online

Opportunity Summary:

The National Institutes of Health (NIH) funding opportunity titled "Research Resource for Human Organs and Tissues (U42)" (Funding Opportunity Number RFA-OD-13-002) supports the continuation of a national research resource that supplies human organs and tissues to biomedical researchers in the United States. This program is meant to sustain and build on a previously supported effort that operated under RFA RR 07-006, with the central goal of keeping high-quality human biospecimens reliably available for research use. The award mechanism is a cooperative agreement (U42), which generally means the NIH expects substantial involvement in shaping or overseeing aspects of the project compared with a standard grant, reflecting the importance of consistent operations, compliance, and service to the broader research community.

At its core, the resource is expected to function as an organized, service-oriented infrastructure that makes it easier for qualified investigators to obtain human tissues and organs for biomedical studies. The scope explicitly includes facilitating procurement (sourcing tissues and organs through appropriate channels), preservation (ensuring proper handling, storage, and methods that protect specimen integrity), and distribution (getting materials to researchers efficiently and in a way that maintains quality and traceability). The emphasis is on supporting biomedical research broadly, so the resource is not simply a local biobank; it is intended to be a dependable national capability that researchers across the U.S. can access, presumably with clear procedures for requesting materials, eligibility verification, and prioritization when supply is limited.

The opportunity was posted on December 20, 2012, with an application due date of February 21, 2013, and it was later archived on March 24, 2013. NIH anticipated making one award, with an estimated total funding level of $1,500,000. There is no cost sharing or matching requirement listed, which typically lowers barriers for applicants that may not have additional non-federal funds available to support the work. The funding activity category is labeled under "Food and Nutrition Health," but the program’s description and the associated CFDA program numbers indicate a broader biomedical and research infrastructure mission that can serve multiple disease and translational research areas.

The listing references multiple CFDA numbers, reflecting the cross-cutting relevance of a human organs and tissues resource to a range of NIH priorities and institutes. These include programs associated with the National Center for Advancing Translational Sciences and Research Infrastructure Programs, as well as disease- and system-focused areas such as blood diseases and resources, arthritis and musculoskeletal/skin research, diabetes and digestive/kidney research, allergy and infectious diseases, and microbiology and infectious diseases. This mix signals that the resource is expected to be broadly useful across many biomedical fields, rather than targeted to a single disease area, and that NIH views the availability of well-managed human specimens as foundational infrastructure that accelerates translational and basic science alike.

Eligibility is broad across U.S.-based organizations, spanning public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) organizations), state and local governments, tribal governments and tribal organizations, and for-profit entities including small businesses. The notice also highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations and U.S. territories or possessions. At the same time, it clearly excludes non-U.S. entities: foreign institutions are not eligible, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed, reinforcing that the supported resource is meant to operate within the United States for the benefit of U.S. biomedical researchers.

Operationally, an award like this typically implies strong expectations around standardization, quality assurance, ethical and regulatory compliance, and transparent access for the research community. While the short description does not list specific requirements, the stated mission of procurement, preservation, and distribution usually involves establishing documented workflows, chain-of-custody and specimen tracking, consistent methods for preservation to maintain scientific usefulness, and a distribution system that can meet investigator needs while protecting donor privacy and adhering to applicable regulations. Because this is framed as a "research resource," it also implies a service model: the resource is expected to enable others’ research by supplying materials in a dependable, well-managed way, rather than focusing primarily on generating its own independent research findings.

For applicants or interested parties, the full announcement was available through the NIH grants guide at the provided link (http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-13-002.html). The contact information included is primarily technical support through the NIH Office of Extramural Research (OER) webmaster for access or linking issues, indicating that detailed scientific or programmatic questions would typically be handled through NIH channels specified in the full FOA text.

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