Opportunity Information: Apply for PAR 16 197
Apply for PAR 16 197
- The HHS-NIH11 in the health, income security and social services sector is offering a public funding opportunity titled "Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865,.
- This funding opportunity was created on Apr 15, 2016 and posted on Apr 15, 2016.
- Applicants must submit their applications by May 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
This funding opportunity, titled "Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R03)" (Funding Opportunity Number PAR 16-197), is a discretionary NIH grant mechanism designed to support small, focused research projects that can quickly generate useful data and sharpen scientific direction in the field of pediatric multiple organ dysfunction syndrome (MODS). Pediatric MODS is a serious clinical condition in which two or more organ systems fail or become severely dysregulated, often in the setting of severe infection, trauma, inflammation, or other critical illness. The opportunity is aimed at improving what is still a limited understanding of why MODS develops in children, how it progresses, and which interventions might prevent it or improve outcomes once it occurs.
The central goal is to advance research that strengthens the scientific foundation for prevention and treatment of MODS in pediatric populations. The announcement emphasizes that MODS is prevalent in critically ill children and is strongly linked to high morbidity and mortality, yet the biological mechanisms, risk factors, trajectories, and optimal management strategies remain insufficiently understood. By encouraging a broad range of research approaches, the program seeks to fill key knowledge gaps across the spectrum from basic mechanisms to translational and clinically oriented work, so that future studies can be better designed and ultimately lead to measurable improvements in clinical care.
Because this is an R03 mechanism, it is generally intended for short-term, limited-scope projects that are tightly defined and feasible with modest resources. In practice, that means applicants are expected to propose studies that can produce concrete deliverables such as preliminary datasets, proof-of-concept findings, validation of an assay or model, development of a new hypothesis supported by early evidence, or pilot testing of an approach that could later be expanded. A major stated expectation is that the work funded here will position investigators to pursue larger, more comprehensive follow-on projects, particularly R01 applications, using the insights, data, and feasibility results generated under this award. The overarching intent is not only to advance knowledge for its own sake, but to speed translation into better prevention and treatment strategies for children at risk for or suffering from MODS.
Administratively, the opportunity is offered by the U.S. Department of Health and Human Services through the National Institutes of Health (Agency: HHS-NIH11), under CFDA numbers 93.865 (and also listing 93.865 in the source). The award ceiling is listed as $50,000, signaling a small grant budget appropriate to pilot or exploratory work. The posting and creation date is April 15, 2016, and the listed closing date for the final submission cycle in the provided data is May 7, 2019. The opportunity category is discretionary, the funding instrument is a grant, and the broad activity area is classified under Health, Income Security and Social Services.
Eligibility is intentionally broad and includes many organization types that might contribute to pediatric critical care and MODS research. Eligible applicants include public institutions (such as state, county, city, township, and special district governments), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, federally recognized Native American tribal governments, other Native American tribal organizations, public housing authorities/Indian housing authorities, nonprofit organizations both with and without 501(c)(3) status (excluding institutions of higher education in those categories), for-profit organizations other than small businesses, and small businesses. The listing also includes an "Others" category with a note to consult additional eligibility text, which is typical for NIH announcements that may allow additional applicant types under specific conditions.
In practical terms, the opportunity is best understood as a targeted call to strengthen the evidence base around pediatric MODS by supporting compact studies that answer high-impact questions and reduce uncertainty in the field. The program frames MODS as both common and devastating in pediatric critical illness and highlights that meaningful progress will require more and better research across multiple disciplines. The intended pathway is straightforward: use R03-scale support to generate credible early findings, then leverage those results into larger NIH-funded investigations, and ultimately convert the science into improved prevention strategies, better clinical decision-making, and more effective treatments that reduce organ failure-related complications and deaths in children.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The opportunity is titled "Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R03)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PAR 16-197.
Which agency is offering this grant?
This is offered by the U.S. Department of Health and Human Services (HHS) through the National Institutes of Health (NIH). The agency reference in the listing is HHS-NIH11.
What type of funding mechanism is this?
This is an NIH R03 mechanism, which is designed to support small, focused research projects that can be completed in a relatively short period and with modest resources.
What is the main purpose of this R03 opportunity?
The central purpose is to advance research that improves the understanding, prevention, and treatment/management of pediatric Multiple Organ Dysfunction Syndrome (MODS), and to fill key knowledge gaps that currently limit progress in clinical care.
What is pediatric MODS in the context of this announcement?
Pediatric MODS is described as a serious clinical condition in which two or more organ systems fail or become severely dysregulated, often occurring in children with severe infection, trauma, inflammation, or other critical illness.
Why is NIH emphasizing pediatric MODS?
The announcement highlights that MODS is prevalent among critically ill children and is strongly associated with high morbidity and mortality, while the underlying mechanisms, risk factors, disease trajectories, and best management strategies remain insufficiently understood.
What kinds of research does this opportunity aim to support?
The program encourages a broad range of approaches across the spectrum of research, including basic mechanistic studies, translational research, and clinically oriented work, as long as the focus is on advancing understanding and management of pediatric MODS.
What is meant by "small, focused research projects" under an R03?
Within the context provided, it means projects that are tightly defined, feasible with modest resources, and capable of quickly generating useful data or clarifying scientific direction in pediatric MODS research.
What deliverables are expected from projects funded under this R03?
Expected deliverables include concrete early outputs such as preliminary datasets, proof-of-concept findings, validation of an assay or model, development of a new hypothesis supported by initial evidence, or pilot testing of an approach that could be expanded later.
Is this grant intended to fund large, long-term studies?
No. The provided information frames the R03 as short-term and limited in scope, intended to generate early findings rather than support large, comprehensive investigations.
How does NIH expect R03 results to be used after the award?
A stated expectation is that findings and feasibility results from this award will position investigators to pursue larger follow-on projects, particularly R01 applications, building on the data and insights generated under the R03.
What is the award ceiling listed for this opportunity?
The award ceiling is listed as $50,000.
What is the funding instrument for this opportunity?
The funding instrument is a grant.
How is the opportunity category described?
The opportunity category is listed as discretionary.
What is the broad activity area classification?
The broad activity area is classified under Health, Income Security and Social Services.
What CFDA number(s) are associated with this opportunity?
The listing associates this opportunity with CFDA 93.865 (and it is also repeated as 93.865 in the source information provided).
When was this opportunity posted/created?
The posting and creation date is April 15, 2016.
What is the closing date listed in the provided information?
The closing date for the final submission cycle in the provided data is May 7, 2019.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include state governments; county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; and small businesses. The listing also includes an "Others" category with a note to consult additional eligibility text.
Are both nonprofit and for-profit organizations eligible?
Yes. The eligibility list includes nonprofit organizations (with and without 501(c)(3) status, with the noted exclusion regarding institutions of higher education in those nonprofit categories) and for-profit organizations other than small businesses, as well as small businesses.
Are tribal entities eligible to apply?
Yes. Federally recognized Native American tribal governments and other Native American tribal organizations are explicitly listed as eligible applicants.
Are educational institutions eligible to apply?
Yes. Public and state-controlled institutions of higher education and private institutions of higher education are included in the eligible applicant types.
Are government entities eligible to apply?
Yes. The eligibility list includes multiple public-sector applicants, including state governments and local governments (county, city, township), as well as special district governments and independent school districts.
What problem is this funding opportunity trying to address?
It is intended to address the limited understanding of why pediatric MODS develops, how it progresses, which children are at risk, and which interventions might prevent MODS or improve outcomes once MODS occurs.
How does this program define impact in practical terms?
The program frames impact as strengthening the scientific foundation for prevention and treatment, accelerating translation into better prevention and treatment strategies, improving clinical decision-making, and ultimately reducing organ failure-related complications and deaths in children.
Does the announcement prioritize any particular research stage (basic vs. clinical)?
Based on the provided information, it encourages a broad range of research stages, spanning basic mechanisms through translational and clinically oriented work, as long as the work advances understanding and management of pediatric MODS.
What is the overall "pathway" NIH is encouraging through this R03?
The intended pathway described is: use R03-scale support to generate credible early findings and feasibility results, leverage those results into larger NIH-funded investigations (especially R01s), and ultimately translate the science into improved prevention and treatment strategies for children.
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