Opportunity Information: Apply for PAR 16 195
Apply for PAR 16 195
- The HHS-NIH11 in the health, income security and social services sector is offering a public funding opportunity titled "Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865,.
- This funding opportunity was created on Apr 15, 2016 and posted on Apr 15, 2016.
- Applicants must submit their applications by May 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The grant opportunity titled "Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R21)" (Funding Opportunity Number PAR 16-195) is a discretionary NIH research grant from the U.S. Department of Health and Human Services (Agency: HHS-NIH11). Its main goal is to stimulate new, exploratory research aimed at improving what is known about pediatric multiple organ dysfunction syndrome (MODS), with a clear emphasis on advancing the understanding of how MODS develops, how it might be prevented, and how it can be treated more effectively in children. The program is framed around the reality that MODS is relatively common in seriously ill pediatric patients and is strongly linked to high morbidity and mortality, yet the scientific and clinical community still lacks a strong, detailed understanding of its mechanisms and best management approaches. Because of that gap, the opportunity is designed to push the field toward novel ideas and early-stage investigations that could ultimately change clinical practice and outcomes.
This funding announcement uses the NIH R21 mechanism, which is specifically intended for exploratory and developmental work. In practical terms, that means applicants are encouraged to propose projects that are at an early conceptual stage, where preliminary data may be limited and the work may be higher-risk than a typical, well-established research pathway. The announcement explicitly signals that the funder is willing to support studies that take on considerable uncertainty in exchange for the possibility of major breakthroughs in pediatric MODS. It is not meant for incremental research that relies on widely accepted methods in mature fields with predictable outcomes. Projects that are narrower, lower-cost, or more straightforward and that mainly apply established approaches are described as a better fit for the R03 small grant mechanism rather than this R21.
The opportunity is broadly open in terms of who can apply, reflecting NIH norms for biomedical and health research. Eligible applicants include various levels of government (state, county, city/township, special districts), independent school districts, public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education under those nonprofit categories), for-profit organizations (including small businesses and other for-profit entities), public housing authorities/Indian housing authorities, and Native American tribal governments and tribal organizations (including both federally recognized tribes and other tribal organizations). The program is categorized under Health, Income Security and Social Services, and it is associated with CFDA numbers 93.865.
From a funding standpoint, the listed award ceiling is $200,000, indicating the upper limit of support expected under this opportunity as presented in the source information. The announcement was created and posted on April 15, 2016, with an application closing date of May 7, 2019 (both the original and current closing dates are shown as the same date in the provided data). While the source data does not specify the number of expected awards, the overarching intent is clear: NIH is trying to seed a pipeline of innovative, early-phase studies that can generate insights, test new hypotheses, and open up promising directions for later, larger-scale investigations.
At its core, the program is oriented toward translation and impact. The funding announcement emphasizes that the long-term hope is for exploratory research findings to lead to improved clinical outcomes for children who have MODS or are at risk of developing it. In other words, even though the grant is designed for early-stage work, the ultimate target is practical progress in pediatric critical care: better prediction, better prevention strategies, more effective treatments, and a stronger scientific foundation for how clinicians understand and manage MODS in children.
Frequently Asked Questions (FAQs)
What is the official title of this grant opportunity?
The opportunity is titled "Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R21)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PAR 16-195.
Which federal agency is offering this grant?
This is an NIH research grant offered by the U.S. Department of Health and Human Services (HHS), specifically under HHS-NIH11.
Is this a discretionary grant?
Yes. It is described as a discretionary NIH research grant.
What is the main purpose of this R21 opportunity?
The main purpose is to stimulate new, exploratory research that advances what is known about pediatric multiple organ dysfunction syndrome (MODS), with an emphasis on understanding how MODS develops, how it might be prevented, and how it can be treated more effectively in children.
What health condition is the program focused on?
The program focuses on multiple organ dysfunction syndrome (MODS) in children, particularly in seriously ill pediatric patients.
Why is NIH funding research on pediatric MODS through this program?
The opportunity is framed around the fact that MODS is relatively common in seriously ill pediatric patients and is strongly linked to high morbidity and mortality, yet there is still not a strong, detailed understanding of its mechanisms and best management approaches. The program is intended to help close that gap.
What kind of research approach is this opportunity trying to encourage?
It is intended to push the field toward novel ideas and early-stage investigations that could ultimately change clinical practice and outcomes for children with MODS or at risk of developing MODS.
What grant mechanism does this opportunity use?
This funding announcement uses the NIH R21 mechanism.
What does it mean that this is an NIH R21 (exploratory/developmental) opportunity?
It means the program is meant for exploratory and developmental work, including projects that may be early in concept and may have limited preliminary data. The intent is to support research that may be higher-risk than more established research pathways, in exchange for the potential for major advances.
Are high-risk ideas acceptable under this announcement?
Yes. The announcement explicitly signals a willingness to support studies that take on considerable uncertainty if they offer the possibility of major breakthroughs in pediatric MODS.
Is this opportunity intended to support incremental or routine research?
No. It is described as not meant for incremental research that relies on widely accepted methods in mature fields with predictable outcomes.
If a project is narrow, lower-cost, or mainly uses established methods, is R21 the best fit?
Not necessarily. The announcement notes that projects that are narrower, lower-cost, more straightforward, and mainly apply established approaches may be a better fit for the R03 small grant mechanism rather than this R21.
Who is eligible to apply?
Eligible applicants include state governments; county governments; city or township governments; special district governments; independent school districts; public and private institutions of higher education; nonprofit organizations (501(c)(3) and non-501(c)(3), excluding institutions of higher education under those nonprofit categories); for-profit organizations (including small businesses and other for-profit entities); public housing authorities/Indian housing authorities; Native American tribal governments (federally recognized); and other Native American tribal organizations.
Can for-profit organizations apply?
Yes. For-profit organizations, including small businesses and other for-profit entities, are listed as eligible applicants.
Can nonprofit organizations apply?
Yes. Both 501(c)(3) and non-501(c)(3) nonprofit organizations are listed as eligible (with the note that institutions of higher education are categorized separately rather than under those nonprofit categories).
Can colleges and universities apply?
Yes. Public and private institutions of higher education are listed as eligible applicants.
Can government entities apply?
Yes. Multiple levels of government are included as eligible applicants, including state, county, city/township, and special district governments, as well as independent school districts.
Are tribal governments or tribal organizations eligible?
Yes. Native American tribal governments (including federally recognized tribes) and other tribal organizations are listed as eligible applicants.
What topic areas or program category is this opportunity associated with?
The opportunity is categorized under Health, Income Security and Social Services.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA number 93.865.
What is the maximum award amount listed for this opportunity?
The listed award ceiling is $200,000, which indicates the upper limit of support expected under this opportunity based on the provided information.
Does the provided information say how many awards NIH expects to make?
No. The source data provided does not specify the number of expected awards.
When was this funding opportunity created and posted?
The announcement was created and posted on April 15, 2016.
What is the application closing date?
The application closing date is May 7, 2019 (the original and current closing dates are shown as the same date in the provided data).
What kinds of outcomes is NIH ultimately trying to influence with this program?
Although the grant supports early-stage work, it is oriented toward translation and impact. The long-term aim is for exploratory findings to contribute to improved clinical outcomes in pediatric critical care, including better prediction, prevention strategies, and more effective treatments for children with MODS or at risk of developing MODS.
What is the overall scientific and clinical gap this program is trying to address?
The program is responding to a gap where MODS is common and associated with severe outcomes in pediatric patients, but the scientific and clinical community still lacks a strong, detailed understanding of MODS mechanisms and best management approaches.
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Applicants who have applied for this opportunity (PAR 16 195) also looked into and applied for these:
| Funding Opportunity |
|---|
| Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R01) Apply for PAR 16 196 Funding Number: PAR 16 196 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R03) Apply for PAR 16 197 Funding Number: PAR 16 197 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Preclinical Research on Model Organisms to Predict Treatment Outcomes for Disorders Associated with Intellectual and Developmental Disabilities (R01) Apply for PAR 16 215 Funding Number: PAR 16 215 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $499,999 |
| Outcome Measures for Use in Treatment Trials of Individuals with Intellectual and Developmental Disabilities (R01) Apply for PAR 16 216 Funding Number: PAR 16 216 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $499,999 |
| Global Network for Womens and Childrens Health Research Data Coordinating Center (U24) Apply for RFA HD 17 010 Funding Number: RFA HD 17 010 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $1,300,000 |
| Understanding STI Co-Infection In At Risk and HIV Infected Adolescents and Young Adults (R01) Apply for RFA HD 17 011 Funding Number: RFA HD 17 011 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $300,000 |
| Characterization of the Adolescent Reproductive Transition (R01) Apply for PA 16 314 Funding Number: PA 16 314 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Safety and Outcome Measures of Pain Medications Used in Children and Pregnant Women (R03) Apply for PA 16 313 Funding Number: PA 16 313 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Safety and Outcome Measures of Pain Medications Used in Children and Pregnant Women (R01) Apply for PA 16 311 Funding Number: PA 16 311 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Characterization of the Adolescent Reproductive Transition (R03) Apply for PA 16 316 Funding Number: PA 16 316 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Safety and Outcome Measures of Pain Medications Used in Children and Pregnant Women (R21) Apply for PA 16 312 Funding Number: PA 16 312 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Understanding STI Co-Infection In At Risk and HIV Infected Adolescents and Young Adults (R21) Apply for RFA HD 17 012 Funding Number: RFA HD 17 012 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Characterization of the Adolescent Reproductive Transition (R21) Apply for PA 16 315 Funding Number: PA 16 315 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Biophysical and Biomechanical Aspects of Embryonic Development (R01) Apply for PAR 16 325 Funding Number: PAR 16 325 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $500,000 |
| Biophysical and Biomechanical Aspects of Embryonic Development (R21) Apply for PAR 16 324 Funding Number: PAR 16 324 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Limited Competition: Clinical Research Investigator Supplement (CRIS) for the Maternal Fetal Medicine Units (MFMU) Network and the Neonatal Research Network (NRN) (Admin Supp) Apply for PA 16 377 Funding Number: PA 16 377 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Contraception Research Centers Program (U54) Apply for RFA HD 17 013 Funding Number: RFA HD 17 013 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $1,500,000 |
| Coordinating Center for NICHD Population Dynamics Centers Research Infrastructure Program, FY 2017 (R24) Apply for RFA HD 17 022 Funding Number: RFA HD 17 022 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $120,000 |
| NICHD Genomic Clinical Variant Expert Curation Panels (U24) Apply for RFA HD 17 001 Funding Number: RFA HD 17 001 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $220,000 |
| Child Health Research Career Development Award (CHRCDA) Program (K12) Apply for RFA HD 18 011 Funding Number: RFA HD 18 011 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $425,000 |
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