Opportunity Information: Apply for RFA CE 12 007

  • The Centers for Disease Control and Prevention in the health sector is offering a public funding opportunity titled "Research to Prevent Prescription Drug Overdoses" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.136 Injury Prevention and Control Research and State and Community Based Programs.
  • This funding opportunity was created on Feb 28, 2012 and posted on Feb 28, 2012.
  • Applicants must submit their applications by May 2, 2012 Letter of Intent Due Date April 2, 2012 Application Due Date May 2, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $600,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
  • Eligible Applicants Eligible Organizations Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education The following types of Higher Education Institutions are always encouraged to apply for CDC support as Public or Private Institutions of Higher Education Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Alaska Native and Native Hawaiian Serving Institutions Nonprofits Other Than Institutions of Higher Education Nonprofits (Other than Institutions of Higher Education) For Profit Organizations Small Businesses For Profit Organizations (Other than Small Businesses) Governments State Governments County Governments City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) Eligible Agencies of the Federal Government U.S. Territory or Possession Other Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American tribal organizations (other than Federally recognized tribal governments) Faith based or Community based Organizations Regional Organizations Bona Fide Agents A Bona Fide Agent is an agency/organization identified by the state as eligible to submit an application under the state eligibility in lieu of a state application. If applying as a bona fide agent of a state or local government, a legal, binding agreement from the state or local government as documentation of the status is required. Attach with Other Attachment Forms when submitting via www.grants.gov. Non domestic (non U.S.) Entities (Foreign Organizations) are not eligible to apply. Foreign (non U.S.) components of U.S. Organizations are not allowed.
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Opportunity Summary:

The Centers for Disease Control and Prevention (CDC), through its National Center for Injury Prevention and Control (NCIPC), offered this discretionary funding opportunity (RFA-CE-12-007) to support research focused on preventing unintentional poisonings from prescription drug overdoses in the United States. The program is centered on adolescents and adults ages 15 to 64, reflecting a broad population segment affected by overdose risk. The core purpose is to strengthen the scientific evidence base for overdose prevention by funding exploratory and developmental studies that test new, potentially high-impact ideas rather than only scaling established interventions. In practice, this means the CDC was looking for projects that could generate early evidence, clarify what works and why, and inform future, larger studies and policy or program decisions aimed at reducing overdose injuries and deaths.

The award mechanism was a Cooperative Agreement, which typically indicates substantial involvement by CDC staff beyond what is common in a standard grant. While the specific roles can vary by project, cooperative agreements often include CDC collaboration on technical guidance, alignment with public health priorities, and shared learning across funded recipients. The activity category was Health, and the CFDA listing was 93.136 (Injury Prevention and Control Research and State and Community Based Programs), placing it within CDCs injury and violence prevention research portfolio rather than a purely clinical or pharmaceutical research lane.

A notable emphasis of the announcement was the expectation of multidisciplinary work. The CDC explicitly framed prescription drug overdose as a complex public health problem that benefits from perspectives spanning epidemiology, community medicine, pharmacology, biostatistics, behavioral and social sciences, public policy, public health law, and justice-related disciplines. This suggests the agency wanted proposals that go beyond describing trends and instead explore real-world prevention levers, such as prescribing practices, patient and provider behavior, community-level risk environments, regulatory and legal approaches, and system-level interventions that can be implemented and evaluated.

Financially, the opportunity anticipated making about three awards, with an estimated total funding amount of $600,000. The award ceiling was $200,000, and there was no stated award floor. The announcement also specified that cost sharing or matching was not required, which can lower the barrier to participation for applicants without access to non-federal matching funds.

Eligibility was broad across the U.S. landscape, including public and private institutions of higher education (with encouragement for Hispanic-serving institutions, HBCUs, tribally controlled colleges and universities, and Alaska Native/Native Hawaiian-serving institutions), nonprofits, for-profit organizations (including small businesses), and a wide range of government entities (state, county, city/township, special district, tribal governments, eligible federal agencies, and U.S. territories or possessions). The announcement also allowed bona fide agents to apply on behalf of a state or local government, provided a formal, binding agreement documenting that status was included. At the same time, the program was limited to domestic applicants: non-U.S. entities were not eligible, and foreign components of U.S. organizations were not permitted.

The timeline was clearly defined: the opportunity was posted on February 28, 2012, with a Letter of Intent due April 2, 2012, and full applications due May 2, 2012. The archive date was June 1, 2012, indicating the funding round had a short application window typical of targeted research solicitations.

Overall, this funding opportunity was designed to seed innovative, early-stage research that could reveal promising strategies to prevent prescription drug overdoses and other unintentional drug poisonings. By prioritizing novel approaches aligned with the NCIPC research agenda and encouraging cross-disciplinary collaboration, the CDC aimed to accelerate practical evidence that could translate into improved prevention programs, policies, and systems impacting overdose risk among teens and adults across the U.S. For access issues or administrative questions, the CDC Procurement and Grants Office listed support via phone (770-488-2700) and email (PGOTIM@cdc.gov).

Frequently Asked Questions (FAQs)

What is the focus of this CDC funding opportunity (RFA-CE-12-007)?

This discretionary funding opportunity from the Centers for Disease Control and Prevention (CDC), through the National Center for Injury Prevention and Control (NCIPC), supported research to prevent unintentional poisonings from prescription drug overdoses in the United States. The intent was to strengthen the scientific evidence base for overdose prevention by funding exploratory and developmental studies.

What population was this program centered on?

The program was centered on adolescents and adults ages 15 to 64, reflecting a broad segment of the U.S. population affected by overdose risk.

What kinds of studies was the CDC looking to fund?

The announcement emphasized exploratory and developmental studies that test new, potentially high-impact ideas. The goal was to generate early evidence, clarify what works (and why), and inform future larger studies as well as policy or program decisions aimed at reducing overdose injuries and deaths.

Was this opportunity meant to scale proven interventions or to test new ideas?

It was positioned to test new ideas rather than only scaling established interventions. The emphasis was on seeding innovative approaches and building early-stage evidence.

What type of award mechanism was used?

The award mechanism was a Cooperative Agreement, which typically involves substantial CDC staff involvement beyond what is common in a standard grant.

What does it mean that the award was a Cooperative Agreement?

A Cooperative Agreement generally indicates that CDC staff may collaborate with recipients in ways such as providing technical guidance, helping align work with public health priorities, and supporting shared learning across funded recipients. Specific roles can vary by project.

What is the activity category for this opportunity?

The activity category was Health.

What CFDA program was associated with this announcement?

The CFDA listing was 93.136: Injury Prevention and Control Research and State and Community Based Programs.

How many awards were anticipated?

The opportunity anticipated making about three awards.

What was the estimated total funding available?

The estimated total funding amount was $600,000.

What was the maximum award amount (award ceiling)?

The award ceiling was $200,000.

Was there a minimum award amount (award floor)?

No award floor was stated in the information provided.

Was cost sharing or matching required?

No. Cost sharing or matching was not required.

Why did the CDC emphasize multidisciplinary work?

The CDC framed prescription drug overdose as a complex public health problem that benefits from multiple perspectives. Disciplines explicitly referenced included epidemiology, community medicine, pharmacology, biostatistics, behavioral and social sciences, public policy, public health law, and justice-related disciplines.

What kinds of prevention approaches or levers were highlighted as relevant?

The description suggested proposals should go beyond describing trends and explore real-world prevention levers such as prescribing practices, patient and provider behavior, community-level risk environments, regulatory and legal approaches, and system-level interventions that can be implemented and evaluated.

Who was eligible to apply?

Eligibility was broad and included public and private institutions of higher education, nonprofits, for-profit organizations (including small businesses), and many types of government entities (state, county, city/township, special district, tribal governments, eligible federal agencies, and U.S. territories or possessions).

Did the opportunity encourage applications from specific types of institutions?

Yes. The opportunity encouraged participation by Hispanic-serving institutions, HBCUs, tribally controlled colleges and universities, and Alaska Native/Native Hawaiian-serving institutions.

Could a bona fide agent apply on behalf of a state or local government?

Yes. A bona fide agent could apply on behalf of a state or local government, but the application needed to include a formal, binding agreement documenting that bona fide agent status.

Were non-U.S. organizations eligible to apply?

No. The program was limited to domestic applicants; non-U.S. entities were not eligible.

Were foreign components of U.S. organizations allowed?

No. Foreign components of U.S. organizations were not permitted.

When was the opportunity posted?

The opportunity was posted on February 28, 2012.

Was a Letter of Intent required, and when was it due?

A Letter of Intent was part of the timeline, and it was due April 2, 2012.

When were full applications due?

Full applications were due May 2, 2012.

What does the archive date mean, and what was it for this opportunity?

The archive date indicates the funding round had closed and was no longer active for new submissions. The archive date listed was June 1, 2012.

What was the overall purpose of the funding program?

The overall purpose was to seed innovative early-stage research aligned with the NCIPC research agenda that could identify promising strategies to prevent prescription drug overdoses and other unintentional drug poisonings, ultimately informing improved prevention programs, policies, and systems.

Who should be contacted for access issues or administrative questions?

The CDC Procurement and Grants Office was listed as the contact for support via phone at 770-488-2700 and email at PGOTIM@cdc.gov.

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