Resource Related Research Projects for Development of Animal Models and Related Materials (R24) | Apply Online

Opportunity Summary:

The Resource Related Research Projects for Development of Animal Models and Related Materials (R24) opportunity (Funding Opportunity Number PAR 10-289) is a National Institutes of Health (NIH) funding announcement issued through the National Center for Research Resources (NCRR), specifically for consideration by the Division of Comparative Medicine. Its core aim is to support resource-focused research projects that strengthen the broader biomedical research community by improving the tools used to study disease in animals. The emphasis is not on a single investigator's hypothesis-driven biological discovery, but on building, refining, validating, and sharing animal-based research resources that many scientists can use across fields.

Projects supported under this announcement are expected to do one or more of the following: develop new animal models of human disease, substantially improve or better characterize existing animal models, or create and improve related materials and methods that make those models more useful and reliable. In parallel, the FOA also encourages work that improves the diagnosis, prevention, monitoring, or control of diseases that affect laboratory animals themselves, since underlying or poorly controlled animal disease can compromise research results and reproducibility. In practice, this can include efforts such as establishing a model with well-defined genetics and phenotype, improving colony health management strategies, developing diagnostic assays for laboratory animal pathogens, or generating standardized reagents, protocols, or data resources tied to model development and validation.

A defining requirement is that the animal model(s) and related resources must address the programmatic research interests of at least two NIH Institutes and Centers (ICs). This is intended to ensure the work has broad, cross-cutting value and is not narrowly tailored to one disease area or one NIH component. Applications that mainly serve the mission of a single NIH Institute or Center, while only loosely or superficially touching others, are explicitly described as not appropriate for this program. The announcement even gives a concrete example: a proposal focused exclusively on an animal model of cancer would be considered inappropriate if it does not meaningfully span the interests of multiple NIH ICs. The underlying message is that applicants should be able to justify how the resulting model or resource will be relevant to multiple research communities and will see use beyond a single niche.

The funding mechanism used is the NIH R24, which is a Resource-Related Research Project grant. R24 awards are commonly used when NIH wants to support a resource that requires active research and development (not just routine service) and that will benefit a wider scientific audience. Under this FOA, award size and exact scope are not fixed in advance because proposed work can vary widely, but awards are expected to be time-limited with a maximum project period of four years. The total funding NIH ultimately commits, and the number of awards made, depend on the quality of applications received, proposed budgets, project duration, and overall costs.

From an administrative standpoint, this is categorized as a discretionary grant opportunity in the health/education funding activity space, and it is listed under CFDA 93.351 (Research Infrastructure Programs). There is no cost sharing or matching requirement stated, meaning applicants are not required to provide a formal matching contribution as a condition of receiving the award. The announcement was posted September 27, 2010, later created in the system June 28, 2013, and reflects closing dates in 2013, with an archive date of July 27, 2013, indicating it is no longer active as written but remains important as a reference for the structure and intent of this R24 program.

Eligibility is broad and includes many organization types commonly able to apply for NIH grants. Eligible applicants include public and private institutions of higher education (including state-controlled institutions), nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those categories as specified), state governments, for-profit organizations other than small businesses, and a variety of tribal entities (federally recognized tribal governments and other tribal organizations). The eligibility section also explicitly includes several additional groups such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, U.S. territories or possessions, regional organizations, and even non-U.S. (foreign) organizations. In practical terms, this wide eligibility aligns with the program goal: building shared animal model resources and laboratory animal health tools can be done in many settings, including specialized research institutes, universities, and organizations with unique animal facilities or expertise.

For applicants seeking the authoritative full text, NIH provided an additional information link to the NIH Grants Guide page for PAR 10-289. The contact information included is operational rather than scientific, pointing applicants to the NIH Office of Extramural Research (OER) Webmaster for technical issues accessing or linking to the announcement.

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