Opportunity Information: Apply for RFA AI 13 054
Apply for RFA AI 13 054
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Resources to Assist Investigations in Primary Immunodeficiency Diseases (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Dec 11, 2013 and posted on Dec 11, 2013.
- Applicants must submit their applications by Apr 17, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $600,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $600,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) County governments For profit organizations other than small businesses Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Special district governments Public and State controlled institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
Resources to Assist Investigations in Primary Immunodeficiency Diseases (U24) is a National Institutes of Health (NIH) cooperative agreement funding opportunity aimed at strengthening the shared infrastructure that makes primary immunodeficiency disease (PID) research possible and faster. Rather than funding a single hypothesis-driven research project, this announcement focuses on sustaining and improving core, community-facing resources that many investigators can use. The overarching goal is to accelerate discovery and translation in PID by ensuring the field has a robust way to identify and characterize patients, access well-annotated biological materials, and train and connect researchers and clinicians through coordinated educational activities.
The FOA centers on three established resource types that applicants are expected to maintain and enhance. First is a registry of individuals with primary immunodeficiency diseases, intended to serve as a centralized platform for collecting, organizing, and sharing high-value clinical and research information about PID populations. This kind of registry typically supports natural history studies, genotype-phenotype investigations, identification of patients for clinical or translational studies, and improved understanding of rare disorders where single institutions may see only small numbers of cases. Second is a repository (biorepository) of cells and other research materials that can be distributed to qualified investigators. By supporting standardized collection, processing, storage, quality control, annotation, and distribution, the repository helps ensure that researchers can obtain reliable samples that are otherwise difficult to access, particularly for rare PID subtypes. Third is an education and outreach component intended to provide training opportunities, disseminate reliable information, and encourage collaboration across the PID community, which may include clinicians, laboratory scientists, trainees, and patient-facing stakeholders. Applicants are expected not only to keep these components running, but to propose concrete plans for improvement over the project period.
This opportunity uses the U24 funding mechanism, meaning it is a cooperative agreement rather than a traditional grant. In practice, that signals substantial NIH involvement during the award, often including coordination, programmatic input, and ongoing collaboration to ensure the resource meets community needs and stays aligned with NIH priorities. The announcement anticipates a single award, suggesting NIH intends to support one coordinating entity to manage and integrate these resources at a national level, rather than funding multiple separate hubs. The estimated total funding is $600,000, with an award ceiling of $600,000, and there is no cost-sharing or matching requirement.
Eligibility is broad across U.S.-based organizations and governments. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and for-profits other than small businesses), and various levels of government (state, county, city/township, special district), along with public housing authorities/Indian housing authorities. The FOA also explicitly lists several institution types and community-based entities as eligible, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies. Foreign institutions are not eligible, and non-U.S. components of U.S. organizations are not eligible. In addition, foreign components (as defined by NIH policy) are not allowed, reinforcing that the funded infrastructure must be U.S.-based and domestically operated.
Key administrative details reflect an older, archived opportunity cycle. The funding opportunity number is RFA-AI-13-054, it was posted and created on December 11, 2013, and the original and current closing date was April 17, 2014. The archive date is May 18, 2014. The activity aligns with NIH’s health mission and is associated with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research), consistent with the focus on immunologic disorders and infectious disease susceptibility that often characterize PID. For access issues with the full announcement, the listed point of contact is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV, and the full FOA was hosted on the NIH grants guide website.
In practical terms, a competitive application under this FOA would be expected to lay out how the applicant will operate these PID resources reliably at scale, improve their utility and reach, and ensure they are accessible and valuable to the broader research community. That typically means clear governance and oversight, rigorous data and biospecimen standards, plans for responsible sharing and privacy protections, strategies to grow participation and engagement, and well-designed training and dissemination activities that actively build collaboration and capacity in PID research.
FAQs: Resources to Assist Investigations in Primary Immunodeficiency Diseases (U24)
What is the purpose of this funding opportunity?
This NIH cooperative agreement is designed to strengthen shared, community-facing infrastructure for primary immunodeficiency disease (PID) research. Instead of supporting a single hypothesis-driven research project, it supports resources many investigators can use to accelerate discovery and translation in PID.
What is the name and mechanism of the opportunity?
The opportunity is titled "Resources to Assist Investigations in Primary Immunodeficiency Diseases (U24)" and uses the U24 mechanism, which is a cooperative agreement rather than a traditional grant.
What does it mean that this is a U24 cooperative agreement?
A U24 cooperative agreement indicates substantial NIH involvement during the award. This typically includes coordination, programmatic input, and ongoing collaboration to help ensure the supported resource stays aligned with NIH priorities and meets community needs.
What kinds of activities are funded under this FOA?
The FOA focuses on sustaining and improving core PID resources that serve the broader research community. The expected scope emphasizes operating, maintaining, integrating, and enhancing shared infrastructure rather than conducting a single stand-alone research project.
Which resource components are applicants expected to maintain and enhance?
Applicants are expected to maintain and improve three established resource types: (1) a registry of individuals with primary immunodeficiency diseases, (2) a repository/biorepository of cells and other research materials for distribution to qualified investigators, and (3) an education and outreach component that supports training, reliable information dissemination, and collaboration across the PID community.
What is the role of the PID patient registry in this program?
The registry is intended to be a centralized platform for collecting, organizing, and sharing high-value clinical and research information about PID populations. It typically supports natural history studies, genotype-phenotype investigations, identification of patients for clinical or translational studies, and improved understanding of rare disorders where single institutions may only see small numbers of cases.
What is the purpose of the biorepository/repository component?
The repository is meant to provide standardized collection, processing, storage, quality control, annotation, and distribution of cells and other research materials. This helps qualified investigators obtain reliable, well-annotated samples that can be difficult to access, especially for rare PID subtypes.
What is meant by "education and outreach" in this FOA?
The education and outreach component is intended to provide training opportunities, disseminate reliable information, and encourage collaboration across the PID community. The FOA describes potential audiences such as clinicians, laboratory scientists, trainees, and patient-facing stakeholders.
Are applicants expected to only maintain existing resources, or also improve them?
Applicants are expected to keep the three components running and to propose concrete plans for improvement over the project period, with the goal of increasing utility, reach, and overall impact for the PID research community.
How many awards does NIH anticipate making?
The announcement anticipates a single award, indicating NIH intended to support one coordinating entity to manage and integrate these PID resources at a national level rather than funding multiple separate hubs.
What is the estimated funding amount and award ceiling?
The estimated total funding is $600,000, and the award ceiling is $600,000.
Is cost-sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and governments. Eligible applicants include public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special district), as well as public housing authorities/Indian housing authorities.
Are specific institution types explicitly included as eligible?
Yes. The FOA explicitly lists several institution types and community-based entities as eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, eligible federal agencies, and others included in the FOA eligibility language.
Are foreign institutions or non-U.S. components eligible?
No. Foreign institutions are not eligible, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed. The FOA reinforces that the funded infrastructure must be U.S.-based and domestically operated.
What is the funding opportunity number?
The funding opportunity number is RFA-AI-13-054.
When was this FOA posted, and what are the key dates?
The FOA was posted/created on December 11, 2013. The original and current closing date was April 17, 2014. The archive date is May 18, 2014.
Is this opportunity current or archived?
Based on the dates provided (closing date in April 2014 and archive date in May 2014), this is an archived opportunity cycle.
What NIH mission areas or program categories are associated with this FOA?
The activity aligns with NIH's health mission and is associated with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research), reflecting the immunologic and infectious disease dimensions often associated with PID.
Where was the full FOA hosted?
The full FOA was hosted on the NIH Grants Guide website.
Who is the contact for access issues with the full announcement?
For access issues, the listed point of contact is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What would a competitive application generally need to address, based on the FOA description?
Based on the information provided, a competitive application would be expected to explain how the applicant will operate PID resources reliably at scale, improve their utility and reach, and ensure broad accessibility and value to the research community. The FOA description highlights typical expectations such as governance and oversight, rigorous data and biospecimen standards, responsible sharing and privacy protections, strategies to grow participation and engagement, and well-designed training and dissemination activities that build collaboration and capacity in PID research.
Is the intent to fund a single hypothesis-driven research project?
No. The FOA emphasizes sustaining and improving shared infrastructure resources for the PID field rather than funding a single hypothesis-driven research project.
What is the overarching goal of supporting these PID resources?
The overarching goal is to accelerate discovery and translation in PID by ensuring the field has robust ways to identify and characterize patients, access well-annotated biological materials, and train and connect researchers and clinicians through coordinated educational activities.
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