Resources to Assist Investigations in Primary Immunodeficiency Diseases (U24) | Apply Online

Opportunity Summary:

The grant opportunity "Resources to Assist Investigations in Primary Immunodeficiency Diseases (U24)" (Funding Opportunity Number RFA-AI-08-066) is a National Institutes of Health program administered through the National Institute of Allergy and Infectious Diseases. Its main goal is to support the continued maintenance and further development of key shared resources that make research on primary immunodeficiency diseases (PIDs) easier, faster, and more collaborative. Rather than funding a single research project focused on one disease mechanism or one patient cohort, this opportunity is geared toward building and sustaining infrastructure that many investigators can rely on over time, especially resources that help connect patients, clinicians, laboratories, and researchers working across different institutions.

The announcement lays out three major categories of resources that applicants are expected to maintain and expand. First is a registry of individuals with primary immunodeficiency disease. In practical terms, this means developing and operating an organized system to collect, manage, and make available information about people diagnosed with PIDs, typically including clinical history, diagnostic details, and other structured data that can help investigators identify patterns, define subgroups, and find potential participants for future studies. A functioning registry also tends to serve as a bridge between clinical sites and research programs by standardizing data collection and improving the ability to conduct multi-site or longitudinal work.

Second is a repository of reagents and other materials intended to support PID research. This component focuses on the physical and informational tools that scientists need in order to run experiments and validate findings. Depending on the scope of the award, a repository could include biological specimens, cell lines, DNA samples, validated antibodies, assay reagents, plasmids, standardized controls, or other specialized materials that are difficult for individual labs to generate and maintain on their own. The central idea is to reduce duplication of effort, improve consistency across studies, and ensure that the broader research community has access to well-characterized materials that can accelerate discovery and translation.

Third is an educational and outreach function, aimed at training, dissemination of information, and encouraging collaborative research in the PID field. This part of the program is meant to strengthen the research ecosystem by sharing best practices, improving awareness of available resources, and helping investigators, trainees, clinicians, and other stakeholders stay current on advances in PID science and care. Educational resources might include workshops, training modules, seminars, curated informational materials, or other efforts that support workforce development and community building. The emphasis on collaboration reflects a recognition that PID research often requires coordinated efforts among multiple disciplines, such as clinical immunology, genetics, infectious diseases, and translational laboratory science.

The mechanism used is a U24 cooperative agreement, which signals that the NIH expects substantial involvement in the funded activities beyond what is typical for a standard grant. In cooperative agreements, the awardee still runs the day-to-day operations, but NIH program staff usually play an active role in oversight, coordination, and strategic direction. Consistent with that collaborative structure, the opportunity specifies that a Steering Committee will be formed after award to assist the recipient in carrying out these activities. A Steering Committee commonly helps set priorities, establish policies for access and distribution of resources, address ethical and governance issues, and ensure the resource remains aligned with the needs of the research community and the institute.

From an administrative standpoint, the opportunity is categorized as discretionary funding and is associated with CFDA numbers 93.855 (Allergy, Immunology and Transplantation Research) and 93.856 (Microbiology and Infectious Diseases Research). The estimated total funding listed is $600,000, and there is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of the award. The posting date is January 12, 2009, with an original closing date of March 9, 2009, later extended to a current closing date of April 14, 2009, and an archive date of May 14, 2009, indicating this is an older, time-limited solicitation rather than an open, rolling program announcement.

Eligibility is broad and includes a wide range of organization types: state and local governments, county and city governments, special district governments, public and private institutions of higher education, public and state-controlled universities, independent school districts, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (including small businesses and other for-profit entities), public housing authorities/Indian housing authorities, and a variety of tribal entities. The eligibility information also explicitly includes groups such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, and even non-U.S. entities and regional organizations. Taken together, that eligibility language suggests NIH was primarily focused on ensuring the best-positioned organization could operate these national or international resources, regardless of whether the applicant was a university, nonprofit, government unit, or other capable institution.

Overall, this funding opportunity is best understood as support for shared research infrastructure in primary immunodeficiency diseases: building and maintaining a patient registry, operating a reagent/materials repository, and providing educational and collaborative tools that expand the field's capacity. The cooperative agreement structure and the planned Steering Committee underscore that NIH intended these resources to be coordinated, community-facing, and responsive to evolving needs, with ongoing input and partnership between the awardee and the institute.

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