Opportunity Information: Apply for PAR 14 012
Apply for PAR 14 012
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Revision Applications for Research on Genomic Underpinnings of Response to Rehabilitation Interventions (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research.
- This funding opportunity was created on Dec 5, 2013 and posted on Dec 5, 2013.
- Applicants must submit their applications by Jun 23, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $100,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Special district governments County governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Independent school districts Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
This grant opportunity (PAR 14-012) is an NIH National Institute of Nursing Research (NINR) call for R01 revision applications, meaning it is not a stand-alone new R01 competition. It is specifically aimed at investigators who already have an active NINR-funded R01 and want to propose an administrative or scientific expansion of that ongoing project to add a focused line of work on genomics and rehabilitation response. The central purpose is to strengthen the evidence base for how genomic variation and related biological mechanisms influence why some people benefit more than others from rehabilitation interventions, with the practical goal of improving functional abilities and quality of life for individuals living with impairments or disability tied to injury, aging, or chronic illness. The FOA frames rehabilitation broadly around maintaining, improving, or restoring function, including common real-world outcomes such as activities of daily living and overall quality of life.
The research emphasis is on understanding and applying the “genomic underpinnings” of response to rehabilitation. Applications can take one of two main directions. First, investigators can focus on discovering or clarifying genomic variants and mechanisms that are associated with outcomes among people receiving rehabilitation interventions. In practice, this could include identifying genetic variants linked to differential recovery trajectories, exploring gene expression or epigenetic patterns that correlate with functional improvement, or examining biologic pathways that help explain symptom burden, resilience, inflammation, tissue repair, neuroplasticity, or other mechanistic contributors to rehabilitation response. Second, investigators can propose to develop and test genomics-informed rehabilitation interventions. That includes tailoring or adapting rehabilitation strategies based on genomic or mechanistic information, as well as interventions that emphasize symptom management or self-management as part of a broader approach to improving function. The overall thrust is translational: building a clearer mechanistic understanding and using it to inform intervention design, targeting, or personalization.
The FOA strongly encourages interdisciplinary research teams, with an explicit emphasis on including nurse scientists as part of the project leadership or team structure. Applicants are also encouraged to leverage existing infrastructure and expertise from Clinical and Translational Science Award (CTSA) sites and/or other federally funded research centers when feasible. This reflects an expectation that genomics-focused rehabilitation research may require specialized resources such as biobanking, genomics cores, data management expertise, clinical research support, community engagement infrastructure, or advanced biostatistics and bioinformatics.
Eligibility hinges on the revision-only nature of the announcement. The Program Director/Principal Investigator must hold an active NINR R01 award, and that parent R01 must have at least two years remaining at the time the proposed revision would begin. Foreign institutions are not eligible, non-U.S. components of U.S. organizations are not eligible, and foreign components are not allowed under NIH policy for this FOA. A wide range of domestic applicant organizations are eligible (including higher education institutions, nonprofits, for-profit entities other than small businesses, small businesses, state/local/tribal governments, and various minority-serving institutions and community-based or faith-based organizations), but they must meet the core requirement of submitting as a revision to an existing active NINR R01.
From an administrative standpoint, the opportunity is categorized as a discretionary grant in the Health/Education activity area under CFDA 93.361 (Nursing Research), with no cost-sharing requirement. The posted date was December 5, 2013, and the application closing date was June 23, 2014 (the opportunity is now archived as of July 24, 2014). The listed award ceiling is $100,000, signaling that proposed revisions should generally be scoped as add-on aims or an expansion that is feasible within a capped supplement-like budget, rather than a full-scale new multi-million-dollar project.
In short, PAR 14-012 supports investigators already funded by NINR to extend their ongoing R01 work by adding genomics-driven questions or genomics-informed intervention development related to rehabilitation outcomes. The intent is to move the field toward a clearer, biologically grounded understanding of individual variation in rehabilitation response and to translate that understanding into more effective, potentially more personalized strategies to improve function and quality of life in populations living with disability or functional impairment.
Frequently Asked Questions (FAQs): PAR-14-012 (NINR) R01 Revision Applications
1) What is PAR-14-012?
PAR-14-012 is a National Institutes of Health (NIH) National Institute of Nursing Research (NINR) funding opportunity announcement (FOA) that invites R01 revision applications to add genomics-focused rehabilitation response work to an already active NINR-funded R01.
2) Is this a stand-alone new R01 grant competition?
No. This FOA is revision-only. It is intended for investigators who already hold an active NINR R01 and want to propose an administrative or scientific expansion of that ongoing parent project.
3) Who is eligible to apply as the Program Director/Principal Investigator (PD/PI)?
The PD/PI must have an active NINR R01 award. In addition, the parent R01 must have at least two years remaining at the time the proposed revision would begin.
4) What is the main purpose of this FOA?
The central purpose is to strengthen the evidence base for how genomic variation and related biological mechanisms influence differential response to rehabilitation interventions, with the practical aim of improving functional abilities and quality of life for people living with impairments or disability related to injury, aging, or chronic illness.
5) How does the FOA define rehabilitation?
The FOA frames rehabilitation broadly as efforts to maintain, improve, or restore function. It highlights real-world outcomes such as activities of daily living and overall quality of life.
6) What kinds of research does this FOA emphasize?
The emphasis is on understanding and applying the genomic underpinnings of response to rehabilitation. The FOA supports work that links genomics and biological mechanisms to why some individuals benefit more than others from rehabilitation interventions.
7) What are the two main directions applicants can take?
Applications can generally fall into one of two directions:
- Discovery/clarification of genomic variants and mechanisms associated with rehabilitation outcomes among people receiving rehabilitation interventions.
- Development and testing of genomics-informed rehabilitation interventions, including tailoring or adapting strategies based on genomic/mechanistic information.
8) What are examples of “discovery” or mechanistic genomics questions that fit?
Examples described in the FOA context include work to identify or examine:
- Genetic variants linked to different recovery trajectories
- Gene expression patterns or epigenetic patterns that correlate with functional improvement
- Biologic pathways related to symptom burden, resilience, inflammation, tissue repair, neuroplasticity, or other mechanistic contributors to rehabilitation response
9) What are examples of genomics-informed rehabilitation interventions under this FOA?
The FOA indicates interventions may include approaches that:
- Tailor or adapt rehabilitation strategies based on genomic or mechanistic information
- Incorporate symptom management or self-management as part of improving function
10) Is the intent basic science, applied research, or translational research?
The thrust is translational: building a clearer mechanistic understanding of rehabilitation response and using that understanding to inform intervention design, targeting, or personalization.
11) Are interdisciplinary teams encouraged?
Yes. The FOA strongly encourages interdisciplinary research teams.
12) Does the FOA specifically mention nurse scientists?
Yes. The FOA explicitly emphasizes including nurse scientists as part of the project leadership or team structure.
13) Are applicants encouraged to use CTSA sites or other federally funded research centers?
Yes. Applicants are encouraged to leverage infrastructure and expertise from Clinical and Translational Science Award (CTSA) sites and/or other federally funded research centers when feasible.
14) Why might CTSA or other center infrastructure be relevant for this work?
The FOA reflects that genomics-focused rehabilitation research may require specialized resources such as:
- Biobanking resources
- Genomics cores
- Data management expertise
- Clinical research support
- Community engagement infrastructure
- Advanced biostatistics and bioinformatics
15) Are foreign institutions eligible?
No. Foreign institutions are not eligible for this FOA.
16) Are non-U.S. components of U.S. organizations eligible?
No. Non-U.S. components of U.S. organizations are not eligible.
17) Are foreign components allowed?
No. Foreign components are not allowed under NIH policy for this FOA.
18) What types of U.S. organizations are eligible (assuming the revision requirement is met)?
The FOA indicates a wide range of domestic organizations may be eligible, including:
- Higher education institutions
- Nonprofits
- For-profit entities (other than small businesses)
- Small businesses
- State, local, or tribal governments
- Minority-serving institutions
- Community-based or faith-based organizations
All eligibility is still contingent on submitting as a revision to an existing active NINR R01 that meets the time-remaining requirement.
19) What is the CFDA number and activity area for this opportunity?
The FOA is listed under CFDA 93.361 (Nursing Research) and categorized as a discretionary grant in the Health/Education activity area.
20) Is cost sharing required?
No. The FOA indicates no cost-sharing requirement.
21) What is the award ceiling, and what does it imply for scope?
The listed award ceiling is $100,000. This signals the revision should be scoped as add-on aims or a feasible expansion within a capped, supplement-like budget, rather than a full-scale, multi-million-dollar new project.
22) What are the key dates for this FOA?
The FOA posted date was December 5, 2013. The application closing date was June 23, 2014. The opportunity is archived as of July 24, 2014.
23) What populations or conditions are the focus of the research?
The FOA targets rehabilitation outcomes and quality of life for individuals living with impairments or disability tied to injury, aging, or chronic illness.
24) What kinds of outcomes does the FOA highlight?
The FOA highlights functional and real-world outcomes, including activities of daily living and overall quality of life, as well as mechanistically linked domains such as symptom burden and biological recovery processes.
25) What is the overall “big picture” goal of PAR-14-012?
The FOA aims to move the field toward a more biologically grounded understanding of individual variation in rehabilitation response and to translate that knowledge into more effective and potentially more personalized strategies that improve function and quality of life.
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| Using Social Media to Understand and Address Substance Use and Addiction (R01) Apply for RFA CA 14 008 Funding Number: RFA CA 14 008 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Using Social Media to Understand and Address Substance Use and Addiction (R21) Apply for RFA CA 14 009 Funding Number: RFA CA 14 009 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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