Opportunity Information: Apply for RFA HL 15 005
Apply for RFA HL 15 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Revision Applications for Research Using Aged Animal Models to Study Chronic Disorders of Heart, Lung, Blood, and Sleep (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233 National Center on Sleep Disorders Research 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Jul 9, 2014 and posted on Jul 9, 2014.
- Applicants must submit their applications by Nov 3, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $600,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $75,000.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education Special district governments County governments Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Small businesses Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
Revision Applications for Research Using Aged Animal Models to Study Chronic Disorders of Heart, Lung, Blood, and Sleep (R01) (RFA-HL-15-005) is a National Institutes of Health grant opportunity from the National Heart, Lung, and Blood Institute (NHLBI) designed to add an aging focus to research that is already underway. The core idea is that many chronic diseases affecting the heart, lungs, blood system, and sleep become more common, more severe, or biologically different with advancing age, yet a large share of preclinical work relies on young adult animals. This FOA aims to close that gap by supporting basic and translational studies that explicitly test how aging and aging-related biological processes shape disease mechanisms and responses to potential therapies.
The announcement is narrowly targeted to revision applications, meaning it is intended only for investigators who already hold an active NHLBI-funded R01 grant and want to extend that parent project. These revisions (previously referred to as competing supplements) must expand the scientific scope of the existing R01 in a way that is tightly connected to the funded aims, but adds new experiments that require age-appropriate nonhuman mammalian models. In practice, the expectation is that the parent project already uses a mammalian animal model to study disease pathogenesis and/or therapeutic strategies, and the revision would introduce aged animals to determine whether the same mechanisms, pathways, phenotypes, or treatment effects hold true in older organisms.
Projects responsive to this FOA are those that use aged animals to examine the influence of aging on chronic disorders within NHLBI mission areas. That can include chronic cardiovascular diseases, chronic lung diseases, blood disorders and hematologic conditions, and sleep and sleep-related disorders. The research emphasis spans both fundamental biology and translational questions, such as identifying age-dependent changes in inflammation, fibrosis, vascular remodeling, immune function, stem or progenitor cell behavior, tissue repair capacity, metabolic regulation, or other aging-linked processes that could plausibly alter disease onset, progression, or therapeutic responsiveness. The unifying requirement is that the revision work meaningfully addresses aging as a biological variable rather than simply repeating existing studies in older animals without a clear rationale.
Funding requested under the revision is specifically allowed to cover two major cost categories: first, obtaining aged animals, either through purchase of animals that are already aged or through the in-house aging of animals over time; and second, the added costs of conducting the new experiments, including personnel needed to execute the expanded work. The overall funding parameters reflect a modest add-on rather than a full new project: total estimated program funding is listed as $600,000 with an expected six awards, and the award ceiling is $75,000. There is no cost sharing or matching requirement.
The opportunity uses the NIH grant mechanism (Grant) and is categorized under Health. The CFDA program areas listed include 93.233 (National Center on Sleep Disorders Research), 93.837 (Cardiovascular Diseases Research), 93.838 (Lung Diseases Research), and 93.839 (Blood Diseases and Resources Research, underscoring the multi-area scope within NHLBI’s mission. The FOA was posted July 9, 2014, with an original and current closing date of November 3, 2015, and an archive date of December 4, 2015, indicating the competition is historical rather than currently open.
Eligibility is broad in terms of institution type, consistent with NIH norms, and includes public and private institutions of higher education, nonprofits (including 501(c)(3) organizations), for-profit organizations other than small businesses, small businesses, and a range of government entities (state, county, city/township, special districts), as well as tribal governments and tribal organizations. It also explicitly recognizes eligibility for organizations such as HBCUs, Hispanic-serving institutions, AANAPISIs, tribal colleges and universities, Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, and U.S. territories or possessions. At the same time, it restricts applications to domestic entities: foreign institutions and non-U.S. components of U.S. organizations are not eligible, and foreign components are not allowed under NIH policy as referenced in the announcement.
In short, this FOA is meant for active NHLBI R01 projects that already use mammalian models and now want to incorporate aged animals to directly test how aging biology changes chronic heart, lung, blood, or sleep disease mechanisms and treatment-related outcomes. It provides limited, targeted funds to acquire and maintain aged animals and to perform the additional experiments and staffing needed to integrate aging into an existing, NHLBI-supported research program.
FAQs: Revision Applications for Research Using Aged Animal Models to Study Chronic Disorders of Heart, Lung, Blood, and Sleep (R01) (RFA-HL-15-005)
What is this funding opportunity trying to accomplish?
This NIH/NHLBI funding opportunity is designed to add an explicit aging focus to research that is already underway. It supports revision applications that expand an active NHLBI-funded R01 project to include experiments in aged (older) nonhuman mammalian models, so investigators can test how aging and aging-related biology influence chronic disorders of the heart, lung, blood system, and sleep, including responses to potential therapies.
Who is this opportunity for?
It is narrowly targeted to investigators who already hold an active R01 grant funded by the National Heart, Lung, and Blood Institute (NHLBI) and who want to extend that parent project via a revision application.
What type of application is allowed (new grant vs. revision)?
Only revision applications are intended under this announcement. The revision must expand the scientific scope of the existing NHLBI-funded R01 while staying tightly connected to the funded aims.
What does "revision application" mean in this context?
In this announcement, a revision application is an application that extends an already-funded NHLBI R01 by adding new, connected work. The new work should add experiments that require age-appropriate nonhuman mammalian models, rather than proposing an unrelated project.
What is the central scientific gap this FOA addresses?
Many chronic diseases affecting heart, lung, blood, and sleep become more common, more severe, or biologically different with advancing age. However, much preclinical research relies on young adult animals. This FOA supports research that directly tests whether disease mechanisms, phenotypes, pathways, and treatment effects differ in older organisms.
What kinds of animal models are expected?
The expectation described is that the parent R01 already uses a mammalian animal model to study disease pathogenesis and/or therapeutic strategies, and the revision adds aged animals to determine whether findings in younger animals hold true in older animals.
Does the revision have to be closely tied to the parent R01?
Yes. The revision must expand the scientific scope of the existing R01 in a way that is tightly connected to the funded aims, while adding new experiments that require age-appropriate nonhuman mammalian models.
What research areas are considered responsive?
Projects are responsive if they use aged animals to examine how aging influences chronic disorders within NHLBI mission areas, including chronic cardiovascular diseases, chronic lung diseases, blood disorders/hematologic conditions, and sleep or sleep-related disorders.
Is the FOA limited to basic science, or can it include translational studies?
It supports both basic and translational studies, as long as the work explicitly tests how aging and aging-related biological processes shape disease mechanisms and responses to potential therapies.
What kinds of aging-related processes are highlighted as relevant?
The announcement points to age-dependent changes such as inflammation, fibrosis, vascular remodeling, immune function, stem or progenitor cell behavior, tissue repair capacity, metabolic regulation, and other aging-linked processes that could alter disease onset, progression, or therapeutic responsiveness.
Is it enough to repeat existing experiments in older animals?
No. The revision work must meaningfully address aging as a biological variable. Simply repeating existing studies in older animals without a clear rationale is not described as responsive.
What costs can the revision funding be used for?
Two major cost categories are specifically allowed: (1) obtaining aged animals, either by purchasing animals that are already aged or by aging animals in-house over time, and (2) the added costs of conducting the new experiments, including personnel needed to carry out the expanded work.
How much funding is available per award?
The award ceiling listed is $75,000, reflecting a modest add-on to an existing project rather than support for a full new project.
What is the total program budget and expected number of awards?
The total estimated program funding is $600,000, with an expected six awards.
Is there any cost sharing or matching requirement?
No. The announcement states there is no cost sharing or matching requirement.
Which NIH institute is sponsoring this opportunity?
The opportunity is from the National Institutes of Health (NIH), specifically the National Heart, Lung, and Blood Institute (NHLBI).
What is the grant mechanism and category?
The mechanism is an NIH Grant using the R01 framework (as a revision to an existing R01). The opportunity is categorized under Health.
Which CFDA program areas are associated with this FOA?
The CFDA program areas listed are 93.233 (National Center on Sleep Disorders Research), 93.837 (Cardiovascular Diseases Research), 93.838 (Lung Diseases Research), and 93.839 (Blood Diseases and Resources Research).
What types of organizations are eligible to apply?
Eligibility includes a wide range of U.S. organization types: public and private institutions of higher education, nonprofits (including 501(c)(3) organizations), for-profit organizations other than small businesses, small businesses, and government entities (state, county, city/township, special districts), as well as tribal governments and tribal organizations. The announcement also explicitly recognizes eligibility for HBCUs, Hispanic-serving institutions, AANAPISIs, tribal colleges and universities, Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, and U.S. territories or possessions.
Are foreign institutions or foreign components eligible?
No. The announcement restricts applications to domestic entities. Foreign institutions and non-U.S. components of U.S. organizations are not eligible, and foreign components are not allowed as referenced in the announcement.
When was the FOA posted and what were the key dates?
The FOA was posted on July 9, 2014. The original and current closing date was November 3, 2015, and the archive date was December 4, 2015.
Is this opportunity currently open?
No. Based on the listed closing date (November 3, 2015) and archive date (December 4, 2015), the competition is historical rather than currently open.
What is the main takeaway for potential applicants?
This FOA was intended for active NHLBI-funded R01 projects that already use mammalian models and want to incorporate aged animals to directly test how aging biology changes chronic heart, lung, blood, or sleep disease mechanisms and treatment-related outcomes, using limited targeted funds to acquire/maintain aged animals and run the added experiments (including staffing).
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