Opportunity Information: Apply for PA 16 043
Apply for PA 16 043
- The HHS-NIH11 in the education, food and nutrition, health sector is offering a public funding opportunity titled "Revision Applications for Validation of Mobile/Wireless Health Tools for Measurement and Intervention (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173, 93.242, 93.286, 93.399, 93.847,.
- This funding opportunity was created on Nov 24, 2015 and posted on Nov 24, 2015.
- Applicants must submit their applications by Jan 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The NIH funding opportunity "Revision Applications for Validation of Mobile/Wireless Health Tools for Measurement and Intervention (R01)" (Funding Opportunity Number PA-16-043) is a discretionary grant program designed specifically for investigators who already hold an active, NIH-supported research project award and want to submit a revision to that existing project. The central purpose is to expand the approved scope of an ongoing NIH-funded study so it can take advantage of newer mobile and wireless health technologies, with an emphasis on validating these tools for two key research uses: (1) measuring health-related behaviors, physiological states, or clinical outcomes, and (2) delivering interventions in a reliable, scientifically defensible way. In practical terms, this FOA supports adding or strengthening mobile and wireless components in an existing research project so the resulting data and intervention delivery methods are accurate, usable, and appropriate for research and potential real-world health applications.
A major theme of the announcement is validation. Rather than simply encouraging the adoption of apps, wearable sensors, or wireless monitoring platforms, NIH is signaling that these tools need to be rigorously tested to confirm they measure what they claim to measure and that they can deliver interventions consistently across users, contexts, and time. The opportunity is aimed at bridging the gap between rapidly evolving consumer and research technologies and the standards required for credible biomedical and behavioral research. That can include validating sensor outputs against gold-standard measures, evaluating reliability across devices and settings, establishing sensitivity to change, confirming feasibility and adherence in target populations, or testing whether mobile-delivered interventions are delivered as intended and produce meaningful, measurable effects.
Although the FOA targets revisions to active projects, it does not require that the parent grant already uses mobile or wireless tools. Investigators can propose bringing these technologies into a project that previously relied on traditional measurement or in-person intervention methods. The key condition is that the applicant team must demonstrate adequate scientific and technical expertise to implement and validate the proposed tools. This matters because mobile and wireless methods often require specialized skills in areas like sensor selection and calibration, software development or integration, data security, signal processing, human factors, and managing high-frequency or continuous data streams. NIH is explicitly leaving the door open for teams to modernize their studies, but expects they can do so competently and responsibly.
The program is administered by the U.S. Department of Health and Human Services through the National Institutes of Health (listed as AgencyName: HHS-NIH11). It uses the R01 research project grant mechanism as the activity type for the revision application, meaning the revision is tied to an existing R01-type project structure and expectations for rigorous research design. The Funding Activity Categories listed (Education, Food and Nutrition, Health) and the CFDA numbers provided (93.173, 93.242, 93.286, 93.399, 93.847) indicate that multiple NIH components and public health research domains may be relevant, reflecting the cross-cutting nature of mobile health measurement and intervention work.
Eligibility is broad in terms of institution type, covering many common research-performing and public-serving organizations. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations other than small businesses; small businesses; and other entities as described in NIH eligibility guidance. While the institution eligibility list is wide, the practical gatekeeper for this FOA is that the applicant must have an active NIH-supported research project award that can serve as the parent grant for the revision.
Key administrative details in the source information show that the FOA was created and posted on November 24, 2015, and that the listed closing date was January 7, 2019 (both original and current closing date). The award ceiling and expected number of awards are not specified in the provided text, which is common in NIH announcements when budgets are determined by the scope and justification of the revision and by the availability of funds within participating institutes.
Overall, PA-16-043 is best understood as an NIH invitation to strengthen existing funded research by adding well-validated mobile and wireless measurement and intervention capabilities. It supports carefully designed expansions that keep the underlying parent study intact while enabling it to incorporate modern, scalable tools that can improve the quality, frequency, and ecological relevance of health data and intervention delivery, provided the team can demonstrate the expertise to do the validation work to NIH standards.
FAQs: NIH PA-16-043 - Revision Applications for Validation of Mobile/Wireless Health Tools for Measurement and Intervention (R01)
What is this funding opportunity?
PA-16-043 is an NIH funding opportunity for discretionary grants that supports revision applications to active, NIH-supported research project awards. The goal is to expand the approved scope of an ongoing NIH-funded study so it can incorporate and validate newer mobile and wireless health technologies used for measurement and/or intervention delivery.
What is the main purpose of PA-16-043?
The central purpose is to help investigators strengthen an already-funded NIH study by adding or improving mobile/wireless components and conducting rigorous validation. NIH is emphasizing that these tools must be tested to ensure they generate accurate, reliable research data and deliver interventions consistently.
Is this opportunity for new projects or existing NIH-funded projects?
This opportunity is specifically for revisions to existing, active NIH-supported research project awards. A parent NIH award must already exist and be active in order to submit a revision under this FOA.
Do we need to already be using mobile or wireless tools in the parent grant?
No. The parent award does not need to already include mobile or wireless tools. Applicants may propose adding these technologies to a study that previously used traditional measurement approaches or in-person intervention delivery. The key expectation is that the team can implement and validate the tools appropriately.
What types of technologies are in scope?
The FOA is aimed at mobile and wireless health technologies such as apps, wearable sensors, wireless monitoring platforms, and related tools that can be used to measure health-related factors or to deliver interventions. The focus is less on adopting technology for its own sake and more on validating that the technology works reliably for research use.
What are the two primary research uses emphasized in the FOA?
The FOA highlights validation for two key uses:
- Measurement of health-related behaviors, physiological states, or clinical outcomes.
- Intervention delivery using mobile/wireless tools in a reliable, scientifically defensible way.
What does NIH mean by "validation" in this FOA?
Validation refers to rigorous testing to confirm that a mobile/wireless tool measures what it claims to measure or delivers an intervention as intended. Examples described in the opportunity include validating sensor outputs against gold-standard measures, evaluating reliability across devices and settings, establishing sensitivity to change, confirming feasibility and adherence in target populations, and testing whether mobile-delivered interventions are delivered consistently and produce measurable effects.
What kinds of validation activities are mentioned as examples?
Examples of validation work mentioned include:
- Comparing sensor outputs to gold-standard measures.
- Testing reliability across devices, contexts, and time.
- Demonstrating sensitivity to change.
- Assessing feasibility and adherence in the target population.
- Confirming interventions are delivered as intended and produce meaningful, measurable effects.
What is the grant mechanism or activity type?
The FOA uses the R01 research project grant mechanism for the revision application. This means the revision is tied to an existing R01-type project structure and expects rigorous research design consistent with NIH standards.
Which federal agency administers this program?
The program is administered by the U.S. Department of Health and Human Services (HHS) through the National Institutes of Health (NIH). The provided agency listing is HHS-NIH11.
What fields or public health domains does this opportunity relate to?
The funding activity categories listed are Education, Food and Nutrition, and Health. The FOA is described as cross-cutting and relevant to multiple NIH components and public health research domains due to the broad applicability of mobile/wireless measurement and intervention tools.
What CFDA numbers are associated with this opportunity?
The CFDA numbers listed for this opportunity are: 93.173, 93.242, 93.286, 93.399, and 93.847.
Who is eligible to apply?
Institutional eligibility is broad and includes, among others:
- State, county, and city/township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments and other tribal organizations
- Public housing authorities/Indian housing authorities
- Nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those categories)
- For-profit organizations other than small businesses
- Small businesses
- Other entities as described in NIH eligibility guidance
However, the practical requirement is that the applicant must have an active NIH-supported research project award that can serve as the parent grant for the revision.
What is the most important eligibility requirement in practice?
Beyond the broad institutional eligibility list, the key gatekeeping requirement is having an active NIH-supported research project award to revise. This FOA is designed for revisions, not standalone applications without a parent award.
What expertise does NIH expect applicant teams to demonstrate?
The FOA emphasizes that teams must demonstrate adequate scientific and technical expertise to implement and validate mobile/wireless tools. The opportunity notes that mobile and wireless methods can require specialized skills such as sensor selection and calibration, software development or integration, data security, signal processing, human factors, and managing high-frequency or continuous data streams.
Why does this FOA emphasize validation instead of simply encouraging technology adoption?
The FOA highlights a gap between rapidly evolving consumer/research technologies and the standards required for credible biomedical and behavioral research. NIH is signaling that these tools need careful testing to ensure they are accurate, reliable, and suitable for research and potential real-world health applications.
What is meant by "expanding the approved scope" of an ongoing study?
In the context provided, it means adding or strengthening mobile/wireless measurement and/or intervention components while keeping the underlying parent study intact. The revision is intended to modernize and enhance what the study can do (for example, improving data quality, frequency, or real-world relevance) by incorporating validated tools.
Is the award ceiling listed?
No. The provided information states that the award ceiling is not specified.
Is the expected number of awards listed?
No. The provided information states that the expected number of awards is not specified.
When was the FOA created and posted?
The FOA was created and posted on November 24, 2015.
What is the closing date listed for this FOA?
The provided information lists a closing date of January 7, 2019 (shown as both the original and current closing date).
How should applicants think about the overall intent of PA-16-043?
Based on the provided description, PA-16-043 is best understood as an NIH invitation to strengthen existing NIH-funded research by adding well-validated mobile and wireless tools for measurement and intervention delivery, with an emphasis on rigorous methods and the expertise needed to execute validation to NIH standards.
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