Revision Applications to P50 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (P50) | Apply Online

Opportunity Summary:

The grant opportunity PAR 13 318, titled "Revision Applications to P50 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (P50)," is a National Institutes of Health (NIH) funding announcement under the National Cancer Institute (NCI) that is specifically designed for existing NCI P50 Specialized Center awardees. It is not a stand-alone new center award. Instead, it supports revision applications (often called competing or non-competing revisions depending on context, but here framed as a revision mechanism) from currently funded SPOREs (Specialized Programs of Research Excellence) or ICMIC Specialized Centers that already operate under the NCI P50 grant mechanism. The overall purpose is to let these active center grants expand their research scope in a targeted way, by adding an additional project that strengthens the parent center's work in early cancer detection.

The scientific focus centers on improving cancer screening, early detection, and diagnostic approaches by bringing together two areas that are often developed separately: imaging technologies and biomarker science. NCI is looking for projects that intentionally combine imaging and biomarker strategies rather than treating them as parallel tracks. On the imaging side, the FOA emphasizes multi-modality imaging strategies, which generally means using more than one imaging method or platform in a coordinated way (for example, combining anatomical and functional imaging, or integrating imaging approaches that capture different biological features). On the biomarker side, the FOA highlights multiplexed biomarker methodologies, meaning approaches capable of measuring multiple biomarkers at once, potentially improving sensitivity, specificity, and overall clinical usefulness for detecting early-stage disease. The underlying idea is that integrating multi-modality imaging with multiplex biomarker measurements can produce stronger, more reliable early detection tools than either approach alone.

A key requirement is that the proposed work must correspond to an added project that expands the scope of the entire parent P50 award. In practical terms, the revision is expected to function as an extension of the center's overall research program rather than a small add-on or isolated experiment. The added project should fit within the center structure and contribute to the broader center objectives, leveraging the infrastructure, collaborations, and translational pathways typical of SPORE or ICMIC programs. The emphasis on early detection and diagnosis implies that applications should be oriented toward approaches that can realistically move the field toward earlier identification of cancers, improved characterization of suspicious findings, or better differentiation of benign versus malignant processes, with the combined imaging-biomarker framework as the centerpiece.

From an administrative standpoint, this is a discretionary grant opportunity with no cost-sharing or matching requirement. It falls under CFDA 93.394, Cancer Detection and Diagnosis Research, and is managed by NIH/NCI. The funding listing provides an award ceiling of $150,000, indicating the maximum amount available under this revision opportunity, which signals that the added project is intended to be focused and strategic rather than the scale of a full new center component. The opportunity was posted August 6, 2013, created August 7, 2013, had an original and final closing date of December 11, 2015, and was archived January 11, 2016, meaning it is no longer open but remains a useful reference for similar future NCI revision initiatives.

Eligibility is broad in terms of institutional types, but it is limited in practice to organizations that already hold eligible, active NCI P50 SPORE or ICMIC Specialized Center awards. The listing includes state and local governments, tribal organizations, public and private institutions of higher education, nonprofits (with and without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, public housing authorities/Indian housing authorities, and other organizational categories described in the FOA. It also explicitly includes a range of mission-serving institutions such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian-serving institutions, among others. At the same time, it clearly restricts foreign participation: non-U.S. entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed.

For applicants needing the full details, NIH provided an official FOA link through the NIH Grants Guide (http://grants.nih.gov/grants/guide/pa-files/PAR-13-318.html). The contact information included is primarily for technical access or linking problems, directing users to the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

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Previous opportunity: Revision Applications to P01 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (P01)

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