Opportunity Information: Apply for RFA DA 14 014

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Revision Applications to Promote Collaborative Research on Addiction at NIH (CRAN) Comorbidity Related Research (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.399 Cancer Control.
  • This funding opportunity was created on Jul 15, 2013 and posted on Jul 15, 2013.
  • Applicants must submit their applications by Sep 24, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $150,000.00 in funding.
  • Eligible applicants include: Public housing authorities/Indian housing authorities Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education City or township governments Small businesses For profit organizations other than small businesses Native American tribal governments (Federally recognized) County governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education State governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Apply for RFA DA 14 014

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Opportunity Summary:

Revision Applications to Promote Collaborative Research on Addiction at NIH (CRAN) Comorbidity Related Research (R01) is a National Institutes of Health (NIH) funding opportunity (RFA-DA-14-014) designed to provide additional, targeted support for researchers who already hold an active NIH R01 award and want to expand that ongoing project in ways that advance the goals of the Collaborative Research on Addiction at NIH (CRAN). The central idea is not to start a brand-new standalone study, but to submit a revision application that augments an existing R01 so the parent project can contribute more directly to CRAN priorities, especially in cross-cutting areas that connect substance use, substance use disorders, and addiction with other health outcomes. This particular call emphasizes comorbidity-related research, meaning projects that address addiction alongside other co-occurring conditions, complications, or intersecting health consequences.

The opportunity falls under the discretionary grant category and uses the NIH grant funding instrument. It is positioned within health and education-related research areas and aligns with multiple CFDA program listings, including Alcohol Research Programs (93.273), Drug Abuse and Addiction Research Programs (93.279), and Cancer Control (93.399). That mix of program areas signals an interest in research that bridges traditional boundaries, such as work that links addiction science with broader biomedical and public health questions, including disease prevention and control topics when relevant. The stated purpose is to strengthen collaborative and integrative research that improves understanding of substance use and addiction and their related health consequences, rather than keeping those topics siloed.

Financially, the FOA lists an estimated total funding amount of about $3,000,000 and an award ceiling of $150,000. In practical terms, that ceiling functions as a cap on the amount of additional funds that can be requested through the revision mechanism for any single award, encouraging focused, additive aims that meaningfully extend the parent R01 without turning the revision into an entirely new project. The FOA specifies that cost sharing or matching is not required, which is consistent with many NIH research grant mechanisms and reduces the burden on applicants to provide non-federal funds.

Eligibility is broad and includes many types of organizations typically able to apply for NIH research funding. Eligible applicants include public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, where applicable), small businesses, for-profit organizations other than small businesses, independent school districts, and a wide range of local and state government entities (cities, townships, counties, states, special district governments, and public housing authorities/Indian housing authorities). The eligibility list also explicitly incorporates a variety of mission-driven and community-serving institutions and entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies. Importantly, the announcement states that non-U.S. entities (foreign organizations and foreign institutions) may apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined under the NIH Grants Policy Statement. This reflects NIH’s willingness to support research capacity and collaborations that extend beyond the United States when scientifically justified.

Timing details show the opportunity was posted and created on July 15, 2013, with an original and current closing date of September 24, 2013, and an archive date of October 25, 2013. Those dates indicate it was a time-limited solicitation with a specific submission window, typical of RFAs aimed at advancing a defined programmatic priority over a particular period. Even though the FOA is archived, its structure is still useful as a model for how NIH uses revision supplements to steer active projects toward emerging or high-priority scientific needs.

Administration and oversight sit within the NIH, and the full announcement was made available through the NIH grants guide. Applicants were directed to the NIH Office of Extramural Research (OER) for technical help accessing or linking to the announcement, with contact through the OER webmaster. Overall, the FOA is best understood as a targeted investment meant to accelerate CRAN-relevant science by leveraging the momentum, infrastructure, and proven feasibility of already-funded R01 projects, while nudging those projects toward collaborative, cross-cutting addiction and comorbidity research questions with clear public health relevance.

FAQs: Revision Applications to Promote Collaborative Research on Addiction at NIH (CRAN) Comorbidity Related Research (R01) (RFA-DA-14-014)

What is this funding opportunity?

This is a National Institutes of Health (NIH) funding opportunity announcement (FOA) titled "Revision Applications to Promote Collaborative Research on Addiction at NIH (CRAN) Comorbidity Related Research (R01)" (RFA-DA-14-014). It supports revision applications that add targeted, CRAN-relevant work onto an already active NIH R01 award.

Is this for a brand-new R01 project?

No. The central purpose is to expand or augment an existing, active NIH R01 award through a revision application. It is not intended to fund a brand-new standalone study.

What does "revision application" mean in this context?

In this FOA, a revision application is a request for additional, targeted support to extend an already-funded parent R01 project so it contributes more directly to CRAN goals. The revision should be additive and focused, rather than transforming the project into an entirely new study.

What is the overall goal of the FOA?

The stated purpose is to strengthen collaborative and integrative research that improves understanding of substance use, substance use disorders, and addiction, along with related health consequences, with an emphasis on cross-cutting work that connects addiction science to other health outcomes.

What does CRAN refer to?

CRAN stands for the Collaborative Research on Addiction at NIH. This FOA is designed to help existing R01 projects advance CRAN priorities by adding revision aims that align with those collaborative, cross-cutting priorities.

What does "comorbidity-related research" mean for this opportunity?

This call emphasizes projects that address addiction in combination with other co-occurring conditions, complications, or intersecting health consequences. The focus is on the connection between substance use/addiction and other health outcomes, rather than treating addiction research as a siloed topic.

What type of grant mechanism and category does this use?

The opportunity is described as a discretionary grant and uses the NIH grant funding instrument. It is built around the NIH R01 context, but specifically supports revisions to active R01 awards.

Which research areas does this FOA align with?

It is positioned within health and education-related research areas and is aligned with multiple CFDA program listings, including Alcohol Research Programs (93.273), Drug Abuse and Addiction Research Programs (93.279), and Cancer Control (93.399). This mix signals interest in research that bridges addiction science with broader biomedical and public health questions, including prevention and control topics when relevant.

How much total funding is estimated for this FOA?

The FOA lists an estimated total funding amount of about $3,000,000.

What is the maximum award amount per project?

The award ceiling listed is $150,000. This functions as a cap on the amount of additional funds that can be requested through the revision mechanism for any single award.

Does the FOA require cost sharing or matching funds?

No. The FOA specifies that cost sharing or matching is not required.

Who is eligible to apply?

Eligibility includes a wide range of organizations typically able to apply for NIH research funding, including public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, where applicable), small businesses, for-profit organizations other than small businesses, independent school districts, and many local and state government entities (such as cities, townships, counties, states, special district governments, and public housing authorities/Indian housing authorities).

Are mission-driven and community-serving institutions explicitly included?

Yes. The eligibility list explicitly includes institutions and entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies.

Can non-U.S. (foreign) organizations apply?

Yes. The announcement states that non-U.S. entities (foreign organizations and foreign institutions) may apply. It also states that non-U.S. components of U.S. organizations are eligible, and that foreign components are allowed as defined under the NIH Grants Policy Statement.

When was this opportunity posted, and what were the deadlines?

The opportunity was posted and created on July 15, 2013. The original and current closing date was September 24, 2013. The archive date is October 25, 2013.

Is this FOA still open?

No. The FOA is archived (archive date: October 25, 2013), and the listed closing date was September 24, 2013, indicating it was time-limited with a defined submission window.

Who administers and oversees this funding opportunity?

Administration and oversight sit within the NIH, and the full announcement was made available through the NIH grants guide.

Where were applicants directed for technical help with accessing or linking to the announcement?

Applicants were directed to the NIH Office of Extramural Research (OER) for technical help, with contact through the OER webmaster.

How should applicants think about the scope of the revision given the award ceiling?

Based on the FOA description, the $150,000 ceiling encourages focused, additive aims that extend the parent R01 in meaningful ways, without turning the revision into a new project.

Why does the FOA reference multiple CFDA listings like alcohol, drug abuse, and cancer control?

The alignment with multiple CFDA program listings suggests an interest in boundary-crossing research that connects addiction science to broader biomedical and public health questions, including prevention and control topics when relevant.

What is the FOA trying to accelerate or leverage?

It is described as a targeted investment meant to accelerate CRAN-relevant science by leveraging the momentum, infrastructure, and proven feasibility of already-funded R01 projects, while nudging those projects toward collaborative, cross-cutting addiction and comorbidity research questions with clear public health relevance.

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