Opportunity Information: Apply for RFA CA 16 010
Apply for RFA CA 16 010
- The HHS-NIH11 in the education, health sector is offering a public funding opportunity titled "Revision Applications to R01 Awards for Research on the NCI's Provocative Questions (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
- This funding opportunity was created on Mar 29, 2016 and posted on Mar 29, 2016.
- Applicants must submit their applications by Oct 28, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The grant opportunity "Revision Applications to R01 Awards for Research on the NCI's Provocative Questions (R01)" (RFA-CA-16-010) is a National Institutes of Health funding announcement from HHS/NIH (specifically the National Cancer Institute) that supports add-on, revision funding to existing NIH R01 grants. Instead of funding entirely new standalone projects, this program is designed for investigators who already hold an active R01 and who want to expand their currently funded work by adding new, well-justified research aims. The overall purpose is to accelerate progress on targeted, high-impact cancer research problems framed by NCI as its "Provocative Questions" (PQs), which are meant to highlight important questions that are understudied, technically challenging, or especially promising for breakthroughs.
A key feature of this FOA is that it only accepts revision applications tied to an active parent R01 award, and the proposed work must be framed as additional specific aims that expand the scope of that parent project. In practical terms, applicants are expected to show a clear scientific and logistical connection between what the R01 is already doing and what the new PQ-focused aims would add. The revision is not meant to replace the original work or redirect the grant into an unrelated area; it is meant to extend the funded research in a way that is both feasible within the existing project context and responsive to one of the designated PQs.
The research focus must align with one of 12 specific NCI Provocative Questions that were previously published for new applications under RFA-CA-15-008 and RFA-CA-15-009. The FOA encourages projects that directly address these PQs, as well as projects that strengthen the overall PQ initiative by validating outcomes from PQ-related research or by supporting adoption and dissemination of PQ research results in ways that can influence cancer research and clinical care. This emphasis signals that NCI is not only interested in novel discovery, but also in confirming, translating, and spreading findings that could change how cancer is understood, studied, prevented, diagnosed, or treated.
From an administrative standpoint, the opportunity is a discretionary grant mechanism, and it sits within NIH health and education-related funding activity categories. Eligible applicants span a broad range of organizations, including state and local governments, public and private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses), and other entities as allowed by the full eligibility language. While many NIH programs skew heavily toward academic institutions, the eligibility list here reflects NIH's broader policy of allowing a range of organizational types, as long as they can appropriately administer the award and carry out the research.
The funding parameters in the source data indicate an award ceiling of $150,000 and an expected total of 3 awards. That combination suggests a relatively competitive, targeted supplement-style program intended to stimulate a small number of focused expansions of existing R01 projects rather than support a large portfolio of new awards. The original and current closing date for the opportunity was October 28, 2016, and the FOA was created and posted on March 29, 2016, placing it as a time-limited funding call aimed at quickly mobilizing investigators already working under R01 support.
Finally, the program is associated with multiple CFDA numbers (93.393, 93.394, 93.395, 93.396, 93.399), which correspond to various NIH/NCI assistance listings related broadly to cancer research and related activities. Overall, the FOA can be read as an NCI strategy to leverage existing NIH-funded infrastructure and teams, push them to tackle carefully selected high-priority cancer questions, and help move PQ-related findings toward validation and real-world impact, all through a revision mechanism that adds new aims to an active R01 rather than starting from scratch.
Frequently Asked Questions (FAQs)
What is the full title and identifier of this grant opportunity?
The opportunity is titled "Revision Applications to R01 Awards for Research on the NCI's Provocative Questions (R01)" and the funding announcement identifier is RFA-CA-16-010.
Which agency is offering this opportunity?
This is a National Institutes of Health (NIH) funding announcement under HHS/NIH, specifically from the National Cancer Institute (NCI).
What is the purpose of this funding announcement?
The purpose is to provide add-on (revision) funding to existing NIH R01 grants so investigators can expand their currently funded work by adding new, well-justified research aims that address NCI's Provocative Questions (PQs) in cancer research.
Is this funding for new standalone projects?
No. This opportunity is designed for revision applications tied to an active parent R01 award. It supports additional aims that expand the scope of the existing R01 rather than creating an entirely new independent project.
Who is this opportunity intended for?
It is intended for investigators who already hold an active NIH R01 and want to extend that project with additional PQ-focused research aims that are clearly connected to the parent award.
What does "revision application" mean in this context?
In this context, a revision application is a request for additional funds to add new specific aims to an active R01. The new work should extend and build on what the parent R01 is already doing, rather than replacing or redirecting it into an unrelated area.
Does the proposed research need to be connected to the parent R01?
Yes. Applicants are expected to demonstrate a clear scientific and logistical connection between the existing R01 project and the new PQ-related aims being proposed under the revision.
Can the revision be used to replace the original aims of the R01?
No. The revision is not meant to replace the original work. It is intended to add new aims that expand the scope of the parent project in a feasible, well-justified way.
What scientific topics does this FOA prioritize?
The research must align with one of 12 specific NCI Provocative Questions (PQs) that were previously published for new applications under RFA-CA-15-008 and RFA-CA-15-009.
Are only brand-new discovery projects encouraged?
No. In addition to projects that directly address the PQs, the FOA also encourages work that strengthens the overall PQ initiative, including validating outcomes from PQ-related research and supporting adoption and dissemination of PQ research results that can influence cancer research and clinical care.
How many Provocative Questions (PQs) are covered by this opportunity?
The FOA specifies that the research must align with one of 12 NCI Provocative Questions.
Where do the Provocative Questions referenced by this FOA come from?
The PQs referenced here are those previously published for new applications under RFA-CA-15-008 and RFA-CA-15-009.
What type of funding mechanism is this?
The opportunity is described as a discretionary grant mechanism within NIH health and education-related funding activity categories.
Which organizations are eligible to apply?
Eligible applicants include a broad range of organizations, such as state and local governments, public and private institutions of higher education, nonprofits (501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses), and other entities as allowed by the full eligibility language.
Are for-profit entities allowed to apply?
Yes. The eligibility list includes for-profit organizations, including small businesses.
Are nonprofits eligible, and does it matter whether they are 501(c)(3)?
Yes. The eligibility list includes nonprofits that are 501(c)(3) as well as nonprofits that are not 501(c)(3).
Are government entities eligible?
Yes. State and local governments are included in the eligible applicant types.
What is the maximum award amount mentioned for this opportunity?
The funding parameters in the provided information indicate an award ceiling of $150,000.
How many awards were expected under this FOA?
The information indicates an expected total of 3 awards.
What does the award ceiling and expected number of awards suggest about competitiveness?
With a $150,000 ceiling and an expected 3 awards, the program appears to be a targeted, competitive opportunity aimed at supporting a small number of focused expansions of existing R01 projects.
When was this FOA posted?
The FOA was created and posted on March 29, 2016.
What was the application closing date?
The original and current closing date listed for the opportunity was October 28, 2016.
What CFDA numbers are associated with this opportunity?
The opportunity is associated with multiple CFDA numbers: 93.393, 93.394, 93.395, 93.396, and 93.399.
Why is NCI using a revision mechanism for the Provocative Questions initiative?
Based on the provided description, the FOA reflects an NCI strategy to leverage existing NIH-funded R01 infrastructure and teams, accelerate progress on high-impact and understudied cancer research questions (PQs), and help move PQ-related findings toward validation and real-world impact by adding new aims to active grants rather than starting from scratch.
Browse more opportunities from the same category: Education, Health
Next opportunity: OJJDP FY 16 Smart on Juvenile Justice: Statewide Juvenile Justice Reform Planning Training & Technical Assistance
Previous opportunity: TRANSFORM/Primary Health Care Unit (PHCU)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA CA 16 010
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA CA 16 010) also looked into and applied for these:
| Funding Opportunity |
|---|
| Revisions to Add Provocative Question-Relevant Research to Active Research Projects (P01) Apply for RFA CA 16 013 Funding Number: RFA CA 16 013 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $150,000 |
| Revisions Applications to P50 Awards for Research on NCI's Provocative Questions (P50) Apply for RFA CA 16 012 Funding Number: RFA CA 16 012 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $150,000 |
| Revision Applications to U01 Awards for Research on the NCI's Provocative Questions (U01) Apply for RFA CA 16 011 Funding Number: RFA CA 16 011 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $150,000 |
| Integrating Biospecimen Science into Clinical Assay Development (U01) Apply for PAR 16 166 Funding Number: PAR 16 166 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $250,000 |
| Novel Strategies for Targeting HIV-CNS Reservoirs without Reactivation (R01) Apply for RFA MH 17 101 Funding Number: RFA MH 17 101 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Novel Strategies for Targeting HIV-CNS Reservoirs without Reactivation (R21) Apply for RFA MH 17 100 Funding Number: RFA MH 17 100 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Pilot and Feasibility Studies Evaluating the Role of RNA Modifications (the 'epitranscriptome') in Cancer Biology (R21) Apply for PA 16 177 Funding Number: PA 16 177 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Exploratory Grants in Cancer Epidemiology and Genomics Research (R21) Apply for PA 16 175 Funding Number: PA 16 175 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| NCI Clinical and Translational Exploratory/Developmental Studies (R21) Apply for PAR 16 176 Funding Number: PAR 16 176 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Improved Technologies and Ligands for Non-invasive Brain Imaging (R43/R44) Apply for RFA DA 17 011 Funding Number: RFA DA 17 011 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Improved Technologies and Ligands for Non-invasive Brain Imaging (R41/R42) Apply for RFA DA 17 010 Funding Number: RFA DA 17 010 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Paul Calabresi Career Development Award for Clinical Oncology (K12) Apply for PAR 16 189 Funding Number: PAR 16 189 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Tools for Cell Line Identification (R43/R44) Apply for PA 16 186 Funding Number: PA 16 186 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Laboratory and Diagnostic Tools to Advance Microbiome-Brain Research (R43/R44) Apply for RFA DA 17 017 Funding Number: RFA DA 17 017 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $150,000 |
| Laboratory and Diagnostic Tools to Advance Microbiome-Brain Research (R41) Apply for RFA DA 17 016 Funding Number: RFA DA 17 016 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $150,000 |
| Improving Smoking Cessation in Socioeconomically Disadvantaged Populations via Scalable Interventions (R01) Apply for PAR 16 202 Funding Number: PAR 16 202 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Improving Smoking Cessation in Socioeconomically Disadvantaged Populations via Scalable Interventions (R21) Apply for PAR 16 201 Funding Number: PAR 16 201 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Growing Great Ideas: Research Education Course in Product Development and Entrepreneurship for Life Science Researchers (R25) Apply for RFA DA 17 007 Funding Number: RFA DA 17 007 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $250,000 |
| NLM Career Development Award in Biomedical Informatics and Data Science (K01) Apply for PAR 16 204 Funding Number: PAR 16 204 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Leveraging Cognitive Neuroscience to Improve Assessment of Cancer Treatment-Related Cognitive Impairment (R21) Apply for PAR 16 213 Funding Number: PAR 16 213 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA CA 16 010", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.