Opportunity Information: Apply for RFA CA 16 011
Apply for RFA CA 16 011
- The HHS-NIH11 in the education, health sector is offering a public funding opportunity titled "Revision Applications to U01 Awards for Research on the NCI's Provocative Questions (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
- This funding opportunity was created on Mar 29, 2016 and posted on Mar 29, 2016.
- Applicants must submit their applications by Oct 28, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The grant opportunity titled "Revision Applications to U01 Awards for Research on the NCI's Provocative Questions (U01)" (RFA-CA-16-011) is a National Cancer Institute (NCI) funding announcement that supports add-on work to existing, active NCI U01 cooperative agreement awards. Rather than funding entirely new standalone projects, it is designed for current U01 awardees who want to submit a revision application that adds new, clearly defined research activities as additional specific aims. In practical terms, the revision must expand the scope of the already-funded parent U01 project, building on its foundation while proposing extra work that fits tightly with the parent award's goals and structure.
A central requirement is that the proposed new aims must align with one of 12 "Provocative Questions" (PQs) identified by NCI and published for new applications in RFA-CA-15-008 and RFA-CA-15-009. The Provocative Questions program is meant to push the field toward important problems in cancer research that are not being adequately addressed, often because they are high-risk, technically challenging, or cross traditional boundaries. This FOA specifically channels revision funding into those PQ areas, meaning the additional aims in the revision application should directly tackle a selected PQ topic rather than simply extending the parent project in an incremental way.
The announcement also emphasizes that revisions can do more than just generate new data. It explicitly encourages research that helps validate outcomes emerging from PQ-related research, as well as efforts aimed at adopting, adapting, or disseminating PQ-driven results in ways that could influence cancer research practices and clinical care. This can include work that strengthens evidence for earlier findings, tests reproducibility or generalizability, or helps move promising PQ insights closer to real-world use. The common thread is that the added aims should produce meaningful forward motion on a PQ and show a plausible pathway to impact, whether through strengthened scientific conclusions, new research tools or approaches, or steps that facilitate translation into clinical or broader research settings.
Mechanistically, the funding instrument is a cooperative agreement (U01), which typically means the project is carried out with substantial scientific or programmatic involvement from NIH/NCI staff compared with a standard research project grant. The activity category is listed under education and health, and the opportunity falls under multiple CFDA numbers (93.393, 93.394, 93.395, 93.396, 93.399), reflecting the various NIH/NCI program authorities that may support cancer-related research. The applicant pool is broad on paper, including state and local governments, public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses), and other entities as allowed in the full eligibility text. However, the practical eligibility bottleneck is that applicants must already hold an active NCI U01 award that can serve as the parent grant for the revision.
In terms of funding scale and timing, the FOA lists an award ceiling of $150,000 and anticipates making about three awards. The posting and creation dates are March 29, 2016, and the application closing date is October 28, 2016 (with no difference between original and current close dates in the provided record). Overall, the opportunity is best understood as a targeted supplement-like mechanism for existing NCI U01 teams to accelerate or broaden their work specifically in directions that answer one of the NCI Provocative Questions, using new specific aims that extend the parent project and are framed to deliver clear scientific or translational value.
FAQs: Revision Applications to U01 Awards for Research on the NCI's Provocative Questions (U01) (RFA-CA-16-011)
What is the purpose of this grant opportunity?
This funding announcement from the National Cancer Institute (NCI) supports revision applications to existing, active NCI U01 cooperative agreement awards. It is meant to fund add-on work that expands the scope of a currently funded parent U01 project by adding new, clearly defined research activities as additional specific aims.
Is this opportunity for brand-new standalone projects?
No. This opportunity is specifically for revision applications to active NCI U01 awards. The application must build on an existing parent U01 and propose additional aims that expand the funded project rather than create a separate, standalone study.
Who is eligible to apply?
The applicant pool is broad in general (including state and local governments, public and private institutions of higher education, nonprofit organizations, for-profit organizations including small businesses, and other entities allowed by the full eligibility text). However, the practical requirement is that the applicant must already have an active NCI U01 award that can serve as the parent grant for the revision.
What does the revision application need to add to the parent U01?
The revision must propose new, clearly defined research activities as additional specific aims. These aims must expand the scope of the already-funded parent U01 project and fit tightly with the parent award's goals and structure.
Do the new aims need to address specific NCI topics?
Yes. The new aims are required to align with one of the 12 NCI "Provocative Questions" (PQs) identified by NCI and published for new applications in RFA-CA-15-008 and RFA-CA-15-009. The added aims should directly tackle a selected PQ topic rather than simply extend the parent project in an incremental way.
What are the "Provocative Questions" (PQs) in this context?
The Provocative Questions program is designed to push cancer research toward important problems that are not being adequately addressed, often because they are high-risk, technically challenging, or cross traditional boundaries. This FOA directs revision funding specifically into those PQ areas.
Can the revision focus on validation or follow-up work rather than entirely new discovery?
Yes. The announcement explicitly encourages work that helps validate outcomes emerging from PQ-related research, including strengthening evidence for earlier findings and testing reproducibility or generalizability.
Does the FOA support adoption, adaptation, or dissemination of PQ-driven results?
Yes. Revisions may include efforts aimed at adopting, adapting, or disseminating PQ-driven results in ways that could influence cancer research practices and clinical care, as long as the added aims clearly advance a PQ area and show a plausible pathway to impact.
How should applicants think about "impact" for the added aims?
The added aims should produce meaningful forward motion on a Provocative Question and show a plausible pathway to impact. Examples described in the opportunity include strengthened scientific conclusions, development of new research tools or approaches, or steps that facilitate translation into clinical or broader research settings.
What funding mechanism is used for this opportunity?
The mechanism is a U01 cooperative agreement. This generally means the project is carried out with substantial scientific or programmatic involvement from NIH/NCI staff compared with a standard research project grant.
What is the award ceiling?
The funding announcement lists an award ceiling of $150,000.
How many awards does NCI expect to make?
The FOA anticipates making about three awards.
What are the key dates listed for this opportunity?
The posting and creation dates are March 29, 2016. The application closing date is October 28, 2016 (the provided record indicates no difference between the original and current close dates).
Which agency is offering this funding?
The opportunity is offered by the National Cancer Institute (NCI).
What activity categories are associated with this FOA?
The activity category is listed under education and health.
Which CFDA numbers are associated with this opportunity?
The FOA references multiple CFDA numbers: 93.393, 93.394, 93.395, 93.396, and 93.399, reflecting different NIH/NCI program authorities that may support cancer-related research.
How should the relationship between the revision and the parent U01 be framed?
The revision should be framed as an expansion of the parent project. The additional specific aims should build on the foundation of the existing U01 while proposing extra work that fits tightly with the parent award's goals and structure, and the added work must be explicitly aligned with a Provocative Question.
What is the overall best way to understand this opportunity?
It is a targeted, supplement-like mechanism for existing NCI U01 teams to accelerate or broaden their work specifically in directions that answer one of the NCI Provocative Questions, using new specific aims that extend the parent project and are designed to deliver clear scientific or translational value.
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