Opportunity Information: Apply for RFA AG 14 015
Apply for RFA AG 14 015
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Revisions for DNA Collection from Existing Longitudinal Aging Cohorts in Africa (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Dec 20, 2013 and posted on Dec 20, 2013.
- Applicants must submit their applications by Mar 4, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Private institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities State governments City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Small businesses Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) County governments Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity "Revisions for DNA Collection from Existing Longitudinal Aging Cohorts in Africa (R01)" (Funding Opportunity Number RFA-AG-14-015) is an NIH initiative, led through the National Institute on Aging (NIA), focused on adding DNA collection to already-established longitudinal aging studies in Africa. Rather than funding entirely new cohorts, this announcement is aimed at revision applications to ongoing projects, specifically to support the practical work needed to obtain DNA samples from older adults (defined here as age 50 and above) who are already participants in two major World Health Organization-supported survey platforms: the Study on global AGEing and Adult Health (SAGE) and the International Network for the Demographic Evaluation of Populations and their Health in Developing Countries (INDEPTH). The central idea is to strengthen the long-term scientific value of these cohorts by ensuring that biological specimens are collected while the participant samples still closely reflect the original study populations.
A key motivation behind this FOA is the time sensitivity of biospecimen collection in longitudinal studies. In long-running cohorts, participant loss over time (attrition) is common, and it is often not random. People may drop out due to illness, disability, migration, or death, and those changes frequently correlate with the very health and aging outcomes researchers want to study. If DNA collection is delayed until later waves, the resulting genetic sample can become skewed toward healthier or more easily followed individuals, making later genetic or gene-environment analyses harder to interpret and potentially biased. This funding opportunity emphasizes collecting DNA sooner rather than later so that future analyses or genotyping can be performed on specimens obtained from a sample that remains as close as possible to the initial sampling frame.
The FOA also highlights why SAGE and INDEPTH are especially valuable targets for this type of investment. Both surveys are longitudinal and conducted in developing-country settings in Africa, and they have a track record of archiving and sharing data in ways that enable use by qualified researchers. Beyond simply having repeated measures, these studies include explicit processes for harmonizing social and behavioral phenotypes with the NIA-supported Health and Retirement Study (HRS) family of surveys conducted globally. That harmonization matters because it supports cross-national comparisons and pooled or parallel analyses, where comparable measures of health, socioeconomic status, functioning, and behavior can be examined alongside genetic information. By enabling DNA collection in cohorts aligned with HRS-style measures, this program is essentially positioning African aging cohorts to contribute to the same kinds of integrative analyses that have become central in aging research elsewhere, including work on genetic associations, gene-by-environment interactions, and the interplay between biology and social determinants of health across diverse contexts.
Administratively, this opportunity is categorized as a discretionary grant using the R01 mechanism (a standard NIH research project grant) and is tied to the aging research CFDA listing 93.866. The total estimated funding amount listed is $1,000,000, and the announcement states there is no cost sharing or matching requirement. The FOA was posted on December 20, 2013, with an original and current closing date of March 4, 2014, and an archive date of April 4, 2014. While the dates indicate this specific call is historical and no longer active, the summary still reflects how NIH has approached targeted revisions to enhance existing cohort infrastructure, particularly for biospecimen collection that increases long-term research utility.
Eligibility for this FOA is broad and includes many types of applicant organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and a range of government entities (state, county, city/township, special district governments, and certain housing authorities). It also explicitly includes tribal governments and tribal organizations, independent school districts, and a wide set of designated institution types such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities. Notably, the FOA allows non-U.S. entities (foreign organizations and foreign institutions) to apply, as well as non-domestic components of U.S. organizations, and it permits foreign components consistent with NIH policy. That breadth aligns with the Africa-based nature of the cohorts and the practical reality that local or regional institutions may be best positioned to carry out field collection, consent processes, sample handling, and coordination with existing cohort operations.
In practical terms, the opportunity is best understood as supporting the additional costs and logistics required to integrate DNA collection into ongoing cohort workflows in SAGE and INDEPTH sites. That can include participant engagement and informed consent for genetic sampling, field protocols for specimen collection, sample processing and storage, quality assurance, and steps needed to make samples usable for future genotyping or other genomic analyses. The FOA frames these activities as essential infrastructure for future science: collecting and preserving DNA now so that downstream research questions, technologies, and collaborations can be pursued later without being limited by missing or biased biospecimen availability.
The sponsoring agency is the National Institutes of Health, and the funding announcement webpage is listed as http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-14-015.html. For technical access issues, the contact provided is the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).
FAQs: Revisions for DNA Collection from Existing Longitudinal Aging Cohorts in Africa (R01) (RFA-AG-14-015)
What is the name of this grant opportunity?
The opportunity is titled "Revisions for DNA Collection from Existing Longitudinal Aging Cohorts in Africa (R01)" and the Funding Opportunity Number is RFA-AG-14-015.
Which agency is sponsoring this funding opportunity?
The sponsoring agency is the National Institutes of Health (NIH), led through the National Institute on Aging (NIA).
What is the main purpose of this FOA?
The FOA is designed to add DNA collection to already-established longitudinal aging cohorts in Africa by supporting revision applications to ongoing projects, rather than creating entirely new cohorts.
Is this opportunity intended for new cohort studies?
No. This announcement is specifically aimed at revision applications to ongoing projects that already have established longitudinal cohorts.
Which existing cohort platforms are specifically targeted?
The FOA targets participants who are already enrolled in two major World Health Organization-supported survey platforms: the Study on global AGEing and Adult Health (SAGE) and the International Network for the Demographic Evaluation of Populations and their Health in Developing Countries (INDEPTH).
Who are the intended study participants for DNA collection?
The DNA collection is focused on older adults defined in this FOA as age 50 and above who are already participants in the targeted longitudinal cohorts.
Why does the FOA emphasize collecting DNA sooner rather than later?
The FOA highlights that attrition in long-running cohorts is common and often not random. Participants may be lost due to illness, disability, migration, or death, and those factors can be linked to health and aging outcomes. If DNA is collected too late, the genetic sample may become biased toward healthier or easier-to-follow individuals, which can complicate or bias later genetic and gene-environment analyses.
What problem is this funding trying to prevent in future genetic analyses?
It aims to reduce the risk that DNA samples come only from a skewed subset of the original cohort due to non-random attrition over time, which can make genetic association or gene-by-environment findings harder to interpret.
What kinds of research value does adding DNA collection provide?
The FOA frames DNA collection as an infrastructure investment that strengthens the long-term scientific value of these cohorts by enabling future genetic, genomic, and gene-environment analyses using specimens collected from a sample that is as close as possible to the original study populations.
Why are SAGE and INDEPTH considered valuable targets for this investment?
They are longitudinal studies in developing-country settings in Africa with a track record of archiving and sharing data for use by qualified researchers. They also include processes to harmonize social and behavioral phenotypes with the NIA-supported Health and Retirement Study (HRS) family of surveys, which supports cross-national comparisons and analyses using comparable measures.
How does harmonization with the Health and Retirement Study (HRS) matter here?
Harmonization supports cross-national comparisons and pooled or parallel analyses by aligning measures of health, socioeconomic status, functioning, and behavior. Adding DNA collection to cohorts with HRS-style measures helps enable integrative aging research that examines genetics alongside social and environmental factors across diverse contexts.
What funding mechanism is used for this opportunity?
This opportunity uses the NIH R01 mechanism (a standard NIH research project grant) and is categorized as a discretionary grant.
What is the CFDA listing associated with this opportunity?
The FOA is tied to the aging research CFDA listing 93.866.
What is the total estimated funding amount listed?
The total estimated funding amount listed in the summary is $1,000,000.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
When was the FOA posted?
The FOA was posted on December 20, 2013.
What were the closing date and archive date for this opportunity?
The original and current closing date was March 4, 2014, and the archive date was April 4, 2014.
Is this FOA currently active?
Based on the listed closing and archive dates, this specific FOA is historical and no longer active.
What types of activities or costs does this FOA support?
It supports the additional costs and logistics required to integrate DNA collection into existing cohort workflows. Examples described include participant engagement and informed consent for genetic sampling, field protocols for specimen collection, sample processing and storage, quality assurance, and steps needed to make samples usable for future genotyping or other genomic analyses.
Does the FOA describe DNA collection as immediate research or future-oriented infrastructure?
The FOA frames DNA collection and preservation as essential infrastructure for future science: collecting DNA now so that downstream research questions, technologies, and collaborations can be pursued later without being limited by missing or biased biospecimen availability.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and many types of government entities (including state, county, city/township, and special district governments, and certain housing authorities). It also includes tribal governments, tribal organizations, and independent school districts.
Are specific designated institution types explicitly included?
Yes. The FOA explicitly includes a wide set of designated institution types such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA allows non-U.S. entities (foreign organizations and foreign institutions) to apply, as well as non-domestic components of U.S. organizations, and it permits foreign components consistent with NIH policy.
Why does the FOA allow foreign entities and components?
The FOA is focused on Africa-based cohorts, and it notes the practical reality that local or regional institutions may be best positioned to handle field collection, consent processes, sample handling, and coordination with existing cohort operations.
Where can the official funding announcement be found?
The FOA webpage is listed as http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-14-015.html.
Who should be contacted for technical access issues related to the FOA page?
For technical access issues, the contact provided is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
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