Opportunity Information: Apply for RFA GM 14 003
Apply for RFA GM 14 003
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Revisions for Macromolecular Interactions in Cells (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Dec 21, 2012 and posted on Dec 21, 2012.
- Applicants must submit their applications by Sep 19, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,200,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $75,000.00 in funding.
- Eligible applicants include: Small businesses Public and State controlled institutions of higher education Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) County governments Special district governments Private institutions of higher education State governments For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity "Revisions for Macromolecular Interactions in Cells (R01)" (Funding Opportunity Number RFA-GM-14-003) is an NIH/NIGMS initiative designed specifically for investigators who already hold active NIGMS R01 or R37 awards. Rather than funding entirely new standalone projects, this program supports revision applications (what used to be called competing supplements) that expand or enhance the scope of an ongoing, NIGMS-funded research project focused on macromolecular interactions and how those interactions relate to cellular function. The central goal is to broaden and strengthen existing research programs that analyze molecular systems and mechanisms in realistic biological contexts, including live organelles, intact cells, tissues, or whole organisms.
A key feature of the FOA is its emphasis on adding capability. Applicants are allowed to request an increased budget in order to pursue a scientifically justified expansion of their current aims or to bring in new experimental or analytical approaches that make the parent project more powerful for studying macromolecular interactions in cells. In practical terms, this means a lab with a strong mechanistic or molecular focus can use this revision mechanism to incorporate new methods, scale up an aspect of the work that was previously constrained by cost, or shift into more physiologically relevant models where macromolecular interactions can be observed and tested in vivo or in situ. The announcement also explicitly highlights a priority: helping modestly funded laboratories gain access to approaches and research directions that would otherwise be financially out of reach, suggesting that enabling capability-building and lowering barriers to advanced techniques is an important motivation for the program.
Collaboration is optional under this FOA. Investigators are not required to form collaborations to be competitive, but they may request funds to support collaborative work when it strengthens the proposed expansion. This can include formal arrangements such as subcontracts to other investigators or institutions that offer complementary expertise, tools, or technologies. The intent is to let applicants build the right team or access the right specialized resources when needed, without making collaboration a mandated structure.
From an administrative standpoint, the opportunity is a discretionary grant program in the NIH biomedical research and research training area (CFDA 93.859). There is no cost-sharing or matching requirement. The FOA listed an estimated total funding level of $3.2 million and an award ceiling of $75,000, indicating that the revisions are meant to be targeted expansions rather than large-scale project overhauls. The posting and creation date were December 21, 2012, with an application closing date of September 19, 2013, and the FOA archived on October 20, 2013.
Eligibility is broad and includes many types of U.S. organizations such as public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) entities), small businesses and other for-profit organizations, and various units of local, county, and state government. The eligibility language also explicitly includes a wide range of institution types (for example, HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and other minority-serving institutions), as well as non-U.S. entities and foreign institutions. Foreign components, as defined by NIH policy, are allowed, and non-U.S. components of U.S. organizations may participate, which provides flexibility for internationally distributed projects as long as they align with NIH rules and the parent award structure.
Overall, this FOA is best understood as a mechanism to push an already-funded NIGMS R01 or R37 project further into the study of macromolecular interactions in living systems by enabling added approaches, expanded scope, and, where useful, targeted collaborations. It is aimed at increasing what existing projects can do, especially where access to specialized methods or resources would otherwise limit the science.
FAQs: Revisions for Macromolecular Interactions in Cells (R01) - RFA-GM-14-003
What is the Revisions for Macromolecular Interactions in Cells (R01) opportunity?
This NIH/NIGMS funding opportunity (RFA-GM-14-003) supports revision applications to expand or enhance the scope of an existing, active NIGMS-funded R01 or R37 project. It is focused on research about macromolecular interactions in cells and how those interactions relate to cellular function.
Is this funding meant for brand-new standalone research projects?
No. This program is designed for revisions to an ongoing NIGMS R01 or R37, not for entirely new standalone projects. The intent is to broaden and strengthen an already-funded research program.
Who is this FOA designed for?
It is designed specifically for investigators who already hold active NIGMS R01 or R37 awards and want to expand the scientific scope or capabilities of that parent project in ways aligned with the FOA's focus on macromolecular interactions in cells.
What research focus does NIGMS emphasize in this FOA?
The FOA emphasizes studying molecular systems and mechanisms in realistic biological contexts. Examples mentioned include live organelles, intact cells, tissues, or whole organisms, with an overarching theme of macromolecular interactions in cells and their relationship to cellular function.
What does "adding capability" mean in the context of this program?
The FOA highlights capability-building as a central feature. Applicants may request an increased budget to support a scientifically justified expansion of current aims or to add new experimental or analytical approaches that make the parent project more powerful for studying macromolecular interactions in cells.
Can the revision application include new methods or approaches?
Yes. The FOA explicitly supports bringing in new experimental or analytical approaches when they strengthen the parent project and help advance the study of macromolecular interactions in realistic biological settings.
Can the revision support moving into more physiologically relevant models?
Yes. The FOA describes using this revision mechanism to shift into more physiologically relevant models where macromolecular interactions can be observed and tested in vivo or in situ.
Is the program intended to help modestly funded labs access advanced techniques?
Yes. The announcement explicitly highlights a priority of helping modestly funded laboratories gain access to approaches and research directions that would otherwise be financially out of reach, indicating that lowering barriers to advanced techniques is an important motivation of the program.
Are collaborations required to be competitive?
No. Collaboration is optional. Investigators are not required to form collaborations to be competitive under this FOA.
Can applicants include collaborative work in the revision request?
Yes. Applicants may request funds to support collaborative work when it strengthens the proposed expansion of the parent project.
What types of collaboration arrangements are mentioned?
The FOA notes that collaborative work can include formal arrangements such as subcontracts to other investigators or institutions that provide complementary expertise, tools, or technologies.
What is the CFDA number and general program area?
The program is listed under CFDA 93.859 and is described as a discretionary grant program in the NIH biomedical research and research training area.
Is cost sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement.
How much funding is available, and what is the maximum award amount?
The FOA lists an estimated total funding level of $3.2 million and an award ceiling of $75,000. This framing suggests the revisions are intended as targeted expansions rather than large-scale overhauls of the parent project.
When was this FOA posted, and what were the key dates?
The posting and creation date were December 21, 2012. The application closing date was September 19, 2013. The FOA was archived on October 20, 2013.
What kinds of organizations are eligible to apply?
Eligibility includes a wide range of U.S. organization types, including public and private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3)), small businesses and other for-profit organizations, and units of local, county, and state government.
Does the FOA explicitly include minority-serving and specialized institution types?
Yes. The eligibility language explicitly includes many institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and other minority-serving institutions.
Are non-U.S. entities or foreign institutions eligible?
Yes. The FOA explicitly includes non-U.S. entities and foreign institutions in its eligibility language.
Are foreign components allowed under this FOA?
Yes. Foreign components, as defined by NIH policy, are allowed. The FOA also notes that non-U.S. components of U.S. organizations may participate, providing flexibility for internationally distributed projects as long as they align with NIH rules and the parent award structure.
How should this FOA be understood at a high level?
It is best understood as a mechanism to push an already-funded NIGMS R01 or R37 project further into the study of macromolecular interactions in living systems by enabling added approaches, expanded scope, and, when useful, targeted collaborations.
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