Opportunity Information: Apply for RFA CA 16 013
Apply for RFA CA 16 013
- The HHS-NIH11 in the education, health sector is offering a public funding opportunity titled "Revisions to Add Provocative Question-Relevant Research to Active Research Projects (P01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
- This funding opportunity was created on Mar 29, 2016 and posted on Mar 29, 2016.
- Applicants must submit their applications by Oct 28, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The grant opportunity titled "Revisions to Add Provocative Question-Relevant Research to Active Research Projects (P01)" (RFA-CA-16-013) is a National Cancer Institute (NCI) Funding Opportunity Announcement that supports add-on revision applications to existing, already-funded NCI P01 Program Project Grants. Rather than funding brand-new standalone P01s, this announcement is aimed at teams that currently hold an active P01 and want to expand their parent project by adding a new, clearly defined research component that fits within the overall theme of the existing program project.
The central purpose of the opportunity is to accelerate progress on a set of high-priority scientific problems known as the NCI Provocative Questions (PQs). Under this FOA, the proposed revision is expected to focus on research tied directly to one of the 12 Provocative Questions referenced in earlier PQ solicitations (RFA-CA-15-008 and RFA-CA-15-009, which were originally designed for new R01 and R21 applications). In practical terms, this means applicants are expected to pick a specific PQ and propose a new project that meaningfully addresses it. The FOA is not limited to only generating new findings; it also encourages work that strengthens, validates, or tests PQ-related outcomes, as well as efforts that help move PQ-derived results into broader use in cancer research and clinical care through adoption and dissemination activities. In other words, the revisions can support both discovery-oriented research and work that helps ensure PQ findings are credible, reproducible, and positioned to make real-world impact.
A key requirement is that the revision must correspond to a new research project that expands the scientific scope of the parent P01 while remaining integrated with the program project as a whole. The intent is not to tack on an unrelated pilot study, but to add a project that complements and strengthens the parent P01's integrated structure, shared theme, and collaborative approach. Because P01s are multi-project program grants, the revision concept is framed as adding a new project to the existing program rather than simply increasing funds for ongoing aims.
From an administrative and funding standpoint, the opportunity is offered by HHS/NIH (specifically NCI, listed under agency name HHS-NIH11) as a discretionary grant. It carries multiple CFDA numbers associated with NCI research programs (93.393, 93.394, 93.395, 93.396, 93.399). The award ceiling listed is $150,000, and the FOA anticipated making around 3 awards, indicating a relatively small, competitive program meant to selectively bolster PQ-relevant research within existing P01 infrastructures.
Eligibility is broad in the sense that many organization types can apply, including state and county governments, public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (including small businesses), and other entities as described in the NIH eligibility text. However, the practical eligibility constraint is that applicants must already be recipients of an active NCI P01 award, since the mechanism is a revision to a parent grant rather than a new award to an unfunded organization.
The FOA was posted and created on March 29, 2016, and the application closing date was October 28, 2016. Overall, the opportunity is best understood as a targeted supplemental pathway for established NCI P01 teams to inject a focused, PQ-driven research project into their ongoing program, with an emphasis on directly answering provocative scientific questions and/or ensuring that PQ-related insights are validated and positioned to influence cancer research and clinical practice.
Frequently Asked Questions (FAQs)
What is the title and ID of this grant opportunity?
The opportunity is titled "Revisions to Add Provocative Question-Relevant Research to Active Research Projects (P01)" and the funding opportunity announcement (FOA) is RFA-CA-16-013.
Which agency is offering this opportunity?
This is a National Cancer Institute (NCI) Funding Opportunity Announcement under HHS/NIH (agency listed as HHS-NIH11).
What type of application does this FOA support?
It supports add-on revision applications to existing, already-funded NCI P01 Program Project Grants. It is not intended to fund brand-new, standalone P01 awards.
Who is this opportunity designed for?
It is designed for teams that currently hold an active NCI P01 Program Project Grant and want to expand their parent project by adding a new, clearly defined research component that fits within the overall theme of the existing program project.
Can an organization apply if it does not already have an active NCI P01 award?
No. While many organization types are listed as eligible in general NIH terms, the practical eligibility requirement is that the applicant must already be a recipient of an active NCI P01 award because the mechanism is a revision to a parent grant.
What is the main scientific purpose of the FOA?
The central purpose is to accelerate progress on a set of high-priority scientific problems known as the NCI Provocative Questions (PQs).
What are the NCI Provocative Questions (PQs) in the context of this FOA?
They are a set of high-priority scientific problems identified by NCI. Under this FOA, the proposed revision is expected to focus on research tied directly to one of the 12 Provocative Questions referenced in earlier PQ solicitations (RFA-CA-15-008 and RFA-CA-15-009).
Does the proposed revision have to address a specific Provocative Question?
Yes. Applicants are expected to pick a specific PQ and propose a new project that meaningfully addresses it.
Is the FOA limited to discovery-oriented research only?
No. The FOA encourages not only generating new findings, but also work that strengthens, validates, or tests PQ-related outcomes. It also encourages efforts that help move PQ-derived results into broader use in cancer research and clinical care through adoption and dissemination activities.
What does NCI mean by "adoption and dissemination activities" in this description?
Based on the description provided, this refers to efforts that help move PQ-derived results into broader use in cancer research and clinical care, positioning findings for real-world impact.
What is required for the revision to be considered responsive to the FOA?
A key requirement is that the revision must correspond to a new research project that expands the scientific scope of the parent P01 while remaining integrated with the program project as a whole.
Can the revision be an unrelated pilot study added onto the parent P01?
No. The intent is not to tack on an unrelated pilot study. The added project should complement and strengthen the parent P01's integrated structure, shared theme, and collaborative approach.
How does this FOA frame the revision within a P01 program structure?
Because P01s are multi-project program grants, the revision concept is framed as adding a new project to the existing program rather than simply increasing funds for ongoing aims.
What is the funding mechanism or assistance type?
The opportunity is offered as a discretionary grant.
What is the maximum award amount (award ceiling) listed?
The listed award ceiling is $150,000.
How many awards were anticipated?
The FOA anticipated making around 3 awards, indicating a small and competitive program.
What CFDA numbers are associated with this opportunity?
The opportunity lists multiple CFDA numbers associated with NCI research programs: 93.393, 93.394, 93.395, 93.396, and 93.399.
What types of organizations are listed as eligible to apply?
Eligibility is described broadly and includes state and county governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (including small businesses); and other entities as described in NIH eligibility text. However, applicants must already have an active NCI P01 award to submit a revision under this FOA.
When was the FOA posted/created?
The FOA was posted and created on March 29, 2016.
What was the application closing date?
The application closing date was October 28, 2016.
In plain terms, what is this opportunity best understood as?
It is a targeted supplemental pathway for established NCI P01 teams to add a focused, PQ-driven research project into their ongoing program, with emphasis on directly answering provocative scientific questions and/or ensuring PQ-related insights are validated and positioned to influence cancer research and clinical practice.
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| Funding Opportunity |
|---|
| Revisions Applications to P50 Awards for Research on NCI's Provocative Questions (P50) Apply for RFA CA 16 012 Funding Number: RFA CA 16 012 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $150,000 |
| Revision Applications to U01 Awards for Research on the NCI's Provocative Questions (U01) Apply for RFA CA 16 011 Funding Number: RFA CA 16 011 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $150,000 |
| Integrating Biospecimen Science into Clinical Assay Development (U01) Apply for PAR 16 166 Funding Number: PAR 16 166 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $250,000 |
| Novel Strategies for Targeting HIV-CNS Reservoirs without Reactivation (R01) Apply for RFA MH 17 101 Funding Number: RFA MH 17 101 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Novel Strategies for Targeting HIV-CNS Reservoirs without Reactivation (R21) Apply for RFA MH 17 100 Funding Number: RFA MH 17 100 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Pilot and Feasibility Studies Evaluating the Role of RNA Modifications (the 'epitranscriptome') in Cancer Biology (R21) Apply for PA 16 177 Funding Number: PA 16 177 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Exploratory Grants in Cancer Epidemiology and Genomics Research (R21) Apply for PA 16 175 Funding Number: PA 16 175 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| NCI Clinical and Translational Exploratory/Developmental Studies (R21) Apply for PAR 16 176 Funding Number: PAR 16 176 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Improved Technologies and Ligands for Non-invasive Brain Imaging (R43/R44) Apply for RFA DA 17 011 Funding Number: RFA DA 17 011 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Improved Technologies and Ligands for Non-invasive Brain Imaging (R41/R42) Apply for RFA DA 17 010 Funding Number: RFA DA 17 010 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Paul Calabresi Career Development Award for Clinical Oncology (K12) Apply for PAR 16 189 Funding Number: PAR 16 189 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Tools for Cell Line Identification (R43/R44) Apply for PA 16 186 Funding Number: PA 16 186 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Laboratory and Diagnostic Tools to Advance Microbiome-Brain Research (R43/R44) Apply for RFA DA 17 017 Funding Number: RFA DA 17 017 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $150,000 |
| Laboratory and Diagnostic Tools to Advance Microbiome-Brain Research (R41) Apply for RFA DA 17 016 Funding Number: RFA DA 17 016 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $150,000 |
| Improving Smoking Cessation in Socioeconomically Disadvantaged Populations via Scalable Interventions (R01) Apply for PAR 16 202 Funding Number: PAR 16 202 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Improving Smoking Cessation in Socioeconomically Disadvantaged Populations via Scalable Interventions (R21) Apply for PAR 16 201 Funding Number: PAR 16 201 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Growing Great Ideas: Research Education Course in Product Development and Entrepreneurship for Life Science Researchers (R25) Apply for RFA DA 17 007 Funding Number: RFA DA 17 007 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $250,000 |
| NLM Career Development Award in Biomedical Informatics and Data Science (K01) Apply for PAR 16 204 Funding Number: PAR 16 204 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Leveraging Cognitive Neuroscience to Improve Assessment of Cancer Treatment-Related Cognitive Impairment (R21) Apply for PAR 16 213 Funding Number: PAR 16 213 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Leveraging Cognitive Neuroscience Research to Improve Assessment of Cancer Treatment Related Cognitive Impairment (R01) Apply for PAR 16 212 Funding Number: PAR 16 212 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
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