Opportunity Information: Apply for RFA HG 09 011
Apply for RFA HG 09 011
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Revolutionary Genome Sequencing Technologies The 1000 Genome (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Jul 17, 2009 and posted on Jul 16, 2009.
- Applicants must submit their applications by Oct 19, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,500,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education State governments Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Non domestic (non U.S.) Entities (Foreign Organizations).
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Opportunity Summary:
Revolutionary Genome Sequencing Technologies The 1000 Genome (R01) is a National Human Genome Research Institute (NHGRI) funding opportunity under the National Institutes of Health (NIH) aimed at pushing DNA sequencing technology to a major cost and performance milestone. The central purpose is to support development of new approaches that can deliver extremely low cost, high quality DNA sequencing, with a specific target of bringing the cost of sequencing a mammalian sized genome down to about 1,000 dollars. The opportunity is designed to accelerate technology breakthroughs rather than incremental improvements, and it explicitly welcomes ideas that differ from the mainstream methods being pursued at the time. Projects can propose an end to end sequencing platform or focus on solving major technical barriers within critical components that would enable a complete 1,000 dollar genome system.
This announcement uses the NIH R01 Research Project Grant mechanism, meaning it is intended for more substantial, hypothesis driven or technology development efforts than smaller exploratory awards. It is part of a coordinated set of solicitations with the same scientific scope, running in parallel with companion announcements that use other mechanisms: an R21 (RFA HG 09 012) for more exploratory or early stage concepts, and an SBIR or STTR pathway via R43/R44 (RFA HG 09 013) for small business oriented development. NHGRI emphasizes that high risk, high payoff proposals are appropriate and expected, reflecting the reality that achieving an order of magnitude shift in sequencing cost and quality will likely require unconventional strategies and significant technical innovation. The intended horizon for reaching the program goals was around 2014, framing the effort as time sensitive and milestone driven.
Funding is contingent on appropriations and on receiving enough highly rated applications. NHGRI anticipated making roughly 2 to 7 awards under this R01 solicitation, with an estimated total of 5 million dollars in total costs available in fiscal year 2010 and again in fiscal year 2011. The listed award ceiling is 1.5 million dollars, indicating that individual projects could be sizable but would still need to fit within an overall portfolio that supports multiple approaches. There is no cost sharing or matching requirement, which is typical for NIH research grants and reduces barriers for applicants proposing ambitious development work.
Eligibility is broad and includes academic institutions, nonprofit organizations (including those with and without 501(c)(3) status, aside from institutions of higher education distinctions), for profit organizations, small businesses, state governments, and public or state controlled institutions of higher education, as well as private higher education institutions. The announcement also notes additional eligible applicants such as federal government agencies and non U.S. entities (foreign organizations), which signals that NHGRI was open to pulling in the best technology concepts globally as long as they met NIH requirements. The funding activity category is health, and the CFDA number associated with the program is 93.172 (Human Genome Research).
Key administrative details include the funding opportunity number RFA HG 09 011 and a posted date of July 16, 2009. The original and current closing date listed is October 19, 2009, with an archive date of November 19, 2009, indicating this specific solicitation is no longer open but remains a useful reference point for understanding the program goals and NIH interest areas. The official announcement link is hosted through the NIH grants guide at http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-09-011.html, and support contacts were routed through the NIH Office of Extramural Research webmaster for access or linking issues.
Frequently Asked Questions (FAQs)
What is the "Revolutionary Genome Sequencing Technologies - The $1000 Genome (R01)" opportunity?
It is a National Human Genome Research Institute (NHGRI) funding opportunity under the National Institutes of Health (NIH) that used the NIH R01 Research Project Grant mechanism to support development of revolutionary DNA sequencing technologies aimed at reaching a major cost and performance milestone.
What is the main goal of this program?
The central purpose is to support new approaches that can deliver extremely low-cost, high-quality DNA sequencing, with a specific target of bringing the cost of sequencing a mammalian-sized genome down to about $1,000.
Is the program looking for incremental improvements to existing sequencing methods?
No. The opportunity is designed to accelerate technology breakthroughs rather than incremental improvements, and it explicitly welcomes ideas that differ from the mainstream methods being pursued at the time.
What types of projects were encouraged to apply?
Applicants could propose an end-to-end sequencing platform or focus on solving major technical barriers within critical components that would enable a complete $1,000 genome system.
What grant mechanism does this announcement use?
This announcement uses the NIH R01 Research Project Grant mechanism, intended for more substantial, hypothesis-driven or technology development efforts than smaller exploratory awards.
Were there companion funding opportunities related to this program?
Yes. The R01 solicitation ran in parallel with companion announcements that shared the same scientific scope, including an R21 for more exploratory or early-stage concepts (RFA HG 09 012) and an SBIR/STTR pathway via R43/R44 for small business-oriented development (RFA HG 09 013).
Does NHGRI encourage high-risk proposals under this opportunity?
Yes. NHGRI emphasized that high-risk, high-payoff proposals are appropriate and expected, recognizing that an order-of-magnitude shift in sequencing cost and quality would likely require unconventional strategies and significant technical innovation.
Was there an intended timeline or horizon for achieving program goals?
Yes. The intended horizon for reaching the program goals was around 2014, framing the effort as time-sensitive and milestone-driven.
How many awards did NHGRI anticipate making under this R01?
NHGRI anticipated making roughly 2 to 7 awards under this R01 solicitation.
How much total funding was estimated for this solicitation?
The estimated total funding available was about $5 million in total costs in fiscal year 2010 and about $5 million in total costs again in fiscal year 2011, contingent on appropriations and on receiving enough highly rated applications.
What was the maximum (ceiling) award amount for an individual project?
The listed award ceiling is $1.5 million, indicating individual projects could be sizable while still supporting multiple approaches across the overall portfolio.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement stated for this opportunity.
Who was eligible to apply?
Eligibility is broad and includes academic institutions, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations, small businesses, state governments, public or state-controlled institutions of higher education, and private institutions of higher education.
Are federal agencies and foreign organizations eligible?
Yes. The announcement notes additional eligible applicants such as federal government agencies and non-U.S. entities (foreign organizations).
What is the funding activity category and CFDA number?
The funding activity category is health. The CFDA number associated with the program is 93.172 (Human Genome Research).
What is the funding opportunity number for this announcement?
The funding opportunity number is RFA-HG-09-011.
When was this funding opportunity posted?
The posted date listed is July 16, 2009.
What were the closing and archive dates?
The original and current closing date listed is October 19, 2009, and the archive date is November 19, 2009.
Is this solicitation still open?
No. Based on the listed closing and archive dates, this specific solicitation is no longer open.
Where is the official announcement posted?
The official announcement is hosted in the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-09-011.html
Who was listed as the support contact for access or linking issues?
Support contacts were routed through the NIH Office of Extramural Research webmaster for access or linking issues.
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA HG 09 011) also looked into and applied for these:
| Funding Opportunity |
|---|
| Revolutionary Genome Sequencing Technologies The 1000 Genome (R21) Apply for RFA HG 09 012 Funding Number: RFA HG 09 012 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Revolutionary Genome Sequencing Technologies The 1000 Genome (SBIR R43/R44) Apply for RFA HG 09 013 Funding Number: RFA HG 09 013 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Awards to Support Research on the Biology of Aging in Invertebrates (R01) Apply for RFA AG 10 004 Funding Number: RFA AG 10 004 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| AHRQ Grants for Health Services Research Dissertation Program (R36) Apply for PAR 09 212 Funding Number: PAR 09 212 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: $40,000 |
| Increasing Immunization Rates through Healthcare Provider Partnerships Apply for CDC RFA IP09 903 Funding Number: CDC RFA IP09 903 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Childhood Immunization Support Project Apply for CDC RFA IP09 904 Funding Number: CDC RFA IP09 904 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $200,000 |
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| Coordination of Activities between the CDC, NCIRD, and State and Local Immunization Programs Apply for CDC RFA IP09 905 Funding Number: CDC RFA IP09 905 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $278,000 |
| Best Practices in Child Welfare Project Apply for USAID RUSSIA OH 09 0002 RFA Funding Number: USAID RUSSIA OH 09 0002 RFA Agency: Russia USAID Moscow Category: Health Funding Amount: $8,500,000 |
| Supplement for Implementing Training of the Sexually Transmitted Disease (STD) Program Management Course Apply for CDC RFA PS06 60601SUPP09 Funding Number: CDC RFA PS06 60601SUPP09 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $200,000 |
| Consortia for High Throughput Enabled Structural Biology Partnerships (U01) Apply for RFA GM 10 007 Funding Number: RFA GM 10 007 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Centers for Membrane Protein Structure Determination (U54) Apply for RFA GM 10 006 Funding Number: RFA GM 10 006 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIAMS Building Interdisciplinary Research Team (BIRT) Revision Awards (R01) Apply for RFA AR 10 001 Funding Number: RFA AR 10 001 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Limited Competition The National Institute on Aging Multicenter Study on Exceptional Survival in Families The Long Life Family Study (LLFS) (U01) Apply for RFA AG 10 005 Funding Number: RFA AG 10 005 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Partnerships for Development of Therapeutics and Diagnostics for Drug Resistant Bacteria and Eukaryotic Parasites (SBIR R43/R44) Apply for RFA AI 09 029 Funding Number: RFA AI 09 029 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Partnerships for Development of Therapeutics and Diagnostics for Drug Resistant Bacteria and Eukaryotic Parasites (R01) Apply for RFA AI 09 026 Funding Number: RFA AI 09 026 Agency: National Institutes of Health Category: Health Funding Amount: $300,000 |
| CHASS Clinical HIV/AIDS Services Strengthening Mozambique Apply for 674 09 062 Funding Number: 674 09 062 Agency: South Africa USAID Pretoria Category: Health Funding Amount: $135,700,000 |
| HLA Region Genomics in Immune Mediated Diseases (U01, U19) Apply for RFA AI 09 030 Funding Number: RFA AI 09 030 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Centers for High Throughput Structure Determination (U54) Apply for RFA GM 10 005 Funding Number: RFA GM 10 005 Agency: National Institutes of Health Category: Health Funding Amount: $8,000,000 |
| Straight Talk on Preventing HIV Program Apply for WH HPP 09 006 Funding Number: WH HPP 09 006 Agency: Office of the Assistant Secretary for Health Category: Health Funding Amount: $200,000 |
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