Opportunity Information: Apply for RFA HG 13 005
Apply for RFA HG 13 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Revolutionary Genome Sequencing Technologies The 1000 Genome (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Oct 21, 2013 and posted on Jun 26, 2013.
- Applicants must submit their applications by Nov 1, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- Eligible applicants include: Independent school districts For profit organizations other than small businesses Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments City or township governments Public housing authorities/Indian housing authorities Special district governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education State governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Revolutionary Genome Sequencing Technologies: The 1000 Genome (R01) is a discretionary National Institutes of Health funding opportunity from the National Human Genome Research Institute (NHGRI) focused on pushing DNA sequencing technology to a dramatically lower cost while maintaining high data quality. The core objective is to enable sequencing of a mammalian-sized genome for roughly $1,000, a benchmark meant to accelerate research and potential clinical use by making whole-genome sequencing far more accessible and scalable. The program is explicitly aimed at technology development rather than routine sequencing projects, with an emphasis on breakthroughs that could change the cost and performance curve of genome sequencing.
The opportunity supports R01 research grants for investigators proposing either complete next-generation sequencing systems or targeted advances in critical components that would unlock a viable $1,000-genome pathway. Applicants can focus on end-to-end platforms (for example, integrated sample preparation through base-calling and analysis) or concentrate on solving key technical bottlenecks such as detection chemistry, signal processing, throughput, accuracy, library preparation, amplification-free methods, single-molecule approaches, nanopore or other sensing modalities, imaging innovations, microfluidics, or computational methods that materially reduce cost without sacrificing quality. NHGRI also encourages proposals that explore approaches beyond the mainstream strategies being pursued at the time, signaling an interest in unconventional concepts, new physical principles, or alternative chemistries that could plausibly reach the target cost point.
A notable feature of this FOA is its openness to high-risk, high-reward science. The institute indicates that ambitious and potentially disruptive ideas are appropriate if they are well-argued and could plausibly deliver major gains in cost, throughput, and quality. In practice, that means applicants are expected to articulate both the transformative potential and a credible plan to reduce technical risk, such as clear milestones, feasibility data when available, thoughtful validation strategies, and realistic pathways to scalability and manufacturability. Because the end goal is “extremely low cost, high quality” sequencing, strong applications would typically address not only raw instrument performance but also total cost of ownership drivers like consumables, workflow complexity, time-to-result, and robustness across diverse samples.
From an administrative standpoint, the Funding Opportunity Number is RFA-HG-13-005, with the title listed as Revolutionary Genome Sequencing Technologies: The 1000 Genome (R01). It falls under the health funding activity category and is associated with CFDA number 93.172 (Human Genome Research). There is no cost sharing or matching requirement. The estimated total funding for the announcement is $4,000,000, and the award ceiling is $1,000,000, indicating that individual awards could be substantial but are capped, and that multiple awards may be expected depending on award size and meritorious applications.
Eligibility is broad and includes a wide range of organizations such as public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), small businesses, for-profit organizations (other than small businesses), and various government entities (state, county, city/township, special districts, and housing authorities). The announcement also lists tribal governments and tribal organizations, and it explicitly includes many mission-focused institution types such as HBCUs, Hispanic-serving institutions, AANAPISIs, TCCUs, Alaska Native and Native Hawaiian serving institutions, and faith-based or community-based organizations. Importantly, non-U.S. entities are eligible: foreign organizations and foreign institutions may apply, foreign components are allowed under NIH policy, and non-domestic components of U.S. organizations are also eligible, which expands participation to international groups positioned to contribute breakthrough sequencing technologies.
Key dates in the source information include a posted date of June 26, 2013, with an original closing date of October 17, 2013, and a current closing date of November 1, 2013; the archive date is December 1, 2013. The official announcement link is provided through the NIH grants website, and contact support is routed through the NIH Office of Extramural Research (OER) webmaster emails for access or linking issues. Overall, the FOA is best understood as a targeted NHGRI push to catalyze transformative sequencing innovations that could make high-quality whole-genome sequencing routine by driving costs down to the $1,000 range through either integrated platforms or breakthrough component technologies.
FAQs: Revolutionary Genome Sequencing Technologies: The 1000 Genome (R01) (RFA-HG-13-005)
What is this funding opportunity?
This is a discretionary National Institutes of Health (NIH) funding opportunity from the National Human Genome Research Institute (NHGRI) titled "Revolutionary Genome Sequencing Technologies: The 1000 Genome (R01)". It supports R01 research grants aimed at major advances in DNA sequencing technology.
What is the main goal of the program?
The core objective is to enable sequencing of a mammalian-sized genome for roughly $1,000 while maintaining high data quality. The intent is to dramatically lower sequencing costs to make whole-genome sequencing far more accessible and scalable for research and potential clinical use.
Is this program meant to fund routine sequencing projects?
No. The program is explicitly focused on technology development rather than routine sequencing. The emphasis is on breakthroughs that can change the cost and performance curve of genome sequencing.
What grant mechanism is being used?
The opportunity supports R01 research grants.
What is the Funding Opportunity Number and title?
The Funding Opportunity Number is RFA-HG-13-005, and the title is Revolutionary Genome Sequencing Technologies: The 1000 Genome (R01).
Which NIH institute is sponsoring this FOA?
The sponsoring institute is the National Human Genome Research Institute (NHGRI), within NIH.
What kinds of projects are encouraged?
Applicants may propose either:
- Complete next-generation sequencing systems (end-to-end platforms), or
- Targeted advances in critical components that unlock a viable pathway to a $1,000 genome.
Can applicants propose an end-to-end sequencing platform?
Yes. The FOA allows proposals for end-to-end platforms, for example integrated workflows spanning sample preparation through base-calling and analysis.
Can applicants focus on only part of the sequencing workflow?
Yes. The FOA also supports targeted work on specific bottlenecks or components, as long as the work materially supports a credible pathway toward extremely low-cost, high-quality sequencing.
What technical areas or components are specifically mentioned as potential focus areas?
The FOA highlights multiple areas, including:
- Detection chemistry
- Signal processing
- Throughput improvements
- Accuracy improvements
- Library preparation
- Amplification-free methods
- Single-molecule approaches
- Nanopore or other sensing modalities
- Imaging innovations
- Microfluidics
- Computational methods that reduce cost without sacrificing quality
Does NHGRI encourage unconventional or non-mainstream approaches?
Yes. NHGRI encourages approaches beyond mainstream strategies, including unconventional concepts, new physical principles, or alternative chemistries that could plausibly reach the $1,000-genome target.
Is this a high-risk, high-reward program?
Yes. The FOA is open to high-risk, high-reward science, including ambitious and potentially disruptive ideas, as long as they are well-argued and plausibly capable of delivering major gains in cost, throughput, and quality.
What does NHGRI expect in terms of risk reduction and credibility?
Applicants are expected to describe both transformative potential and a credible plan to reduce technical risk. The FOA points to elements such as clear milestones, feasibility data when available, validation strategies, and realistic pathways toward scalability and manufacturability.
Does the FOA care only about instrument performance?
No. Because the end goal is extremely low-cost, high-quality sequencing, strong applications would typically address total cost and operational drivers such as consumables, workflow complexity, time-to-result, and robustness across diverse samples, in addition to raw performance.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA 93.172 (Human Genome Research).
Is there a cost sharing or matching requirement?
No. The FOA states that there is no cost sharing or matching requirement.
How much total funding is estimated for this announcement?
The estimated total funding is $4,000,000.
What is the maximum award amount (award ceiling)?
The award ceiling is $1,000,000.
Does the combination of total funding and award ceiling suggest multiple awards?
Yes. With an estimated total of $4,000,000 and a $1,000,000 ceiling per award, the FOA suggests that multiple awards may be expected, depending on award sizes and the number of meritorious applications.
Who is eligible to apply?
Eligibility is broad and includes many organization types, including:
- Public and private institutions of higher education
- Nonprofits (with and without 501(c)(3) status)
- Small businesses
- For-profit organizations (other than small businesses)
- State governments
- County governments
- City or township governments
- Special district governments
- Housing authorities
- Tribal governments and tribal organizations
- HBCUs, Hispanic-serving institutions, AANAPISIs, TCCUs, Alaska Native and Native Hawaiian serving institutions
- Faith-based and community-based organizations
Are foreign (non-U.S.) organizations eligible?
Yes. The announcement states that foreign organizations and foreign institutions may apply. It also allows foreign components under NIH policy and permits non-domestic components of U.S. organizations.
What is the funding activity category?
The FOA is listed under the health funding activity category.
When was the opportunity posted?
The posted date is June 26, 2013.
What are the closing dates listed for this FOA?
The source information lists an original closing date of October 17, 2013, and a current closing date of November 1, 2013.
When is the archive date?
The archive date is December 1, 2013.
Where is the official announcement hosted?
The official announcement is provided through the NIH grants website (per the source information).
Who is listed for support or help with access/linking issues?
Support for access or linking issues is routed through the NIH Office of Extramural Research (OER) webmaster emails, as noted in the source information.
What is the simplest way to describe what NHGRI is trying to catalyze here?
This FOA is a targeted push to catalyze transformative sequencing innovations that could make high-quality whole-genome sequencing routine by driving costs toward the $1,000 genome level through integrated platforms or breakthrough component technologies.
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