Opportunity Information: Apply for RFA HG 09 012
Apply for RFA HG 09 012
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Revolutionary Genome Sequencing Technologies The 1000 Genome (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Jul 17, 2009 and posted on Jul 17, 2009.
- Applicants must submit their applications by Oct 19, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Private institutions of higher education Public and State controlled institutions of higher education State governments.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Non domestic (non U.S.) Entities (Foreign Organizations).
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Opportunity Summary:
The funding opportunity titled "Revolutionary Genome Sequencing Technologies: The 1000 Genome (R21)" (Funding Opportunity Number RFA-HG-09-012) is an NIH grant solicitation from the National Human Genome Research Institute (NHGRI) aimed at pushing DNA sequencing technology to a dramatically lower cost point while maintaining high data quality. The central target is ambitious: to make it feasible to sequence a mammalian-sized genome for about $1,000. The program is explicitly oriented toward technology development rather than incremental improvement, and it is framed as an effort to stimulate breakthroughs that could change the economics and scalability of genome sequencing.
This announcement uses the NIH Exploratory/Developmental Research Grant mechanism (R21), which is commonly used for early-stage, high-risk projects that may not yet have extensive preliminary data but have strong potential for major impact. Applicants are invited to propose either complete end-to-end sequencing platforms or focused projects that tackle major technical barriers within critical components of sequencing systems. In other words, the solicitation is open both to teams building fully integrated sequencing approaches and to teams solving key enabling problems (for example, chemistry, detection methods, sample preparation, signal processing, throughput, error correction, or other fundamental hurdles that limit cost and quality). NHGRI also signals that it is looking for genuinely novel ideas, including approaches beyond the mainstream strategies being pursued at the time, and it explicitly encourages "high risk/high payoff" proposals. The timeline goal mentioned in the notice is to help drive progress toward the $1,000 genome objective by around 2014.
The opportunity is categorized as a discretionary grant in the health domain (CFDA 93.172, Human Genome Research) and does not require cost sharing or matching. It was posted on July 17, 2009, with an application closing date of October 19, 2009, and an archive date of November 19, 2009. NHGRI anticipated making roughly 2 to 7 awards, depending on the availability of funds and the quality of applications received. The estimated total funding level listed is $2,000,000 in total costs for FY2010, with the notice indicating a similar amount again in FY2011 in response to the FOA. The award ceiling shown in the record is $200,000, reflecting the smaller, exploratory nature typical of R21 awards.
Eligibility is broad and includes many organizational types across academia, government, and industry. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including 501(c)(3) nonprofits and certain nonprofits without 501(c)(3) status), for-profit organizations other than small businesses, and small businesses, as well as state governments. The eligibility text also notes additional eligible applicants such as federal government agencies and non-U.S. entities (foreign organizations), indicating that participation was not limited strictly to domestic institutions.
This R21 solicitation was also designed to run in parallel with other funding announcements of the same scientific scope but different mechanisms: an R01 version (RFA-HG-09-011) for more mature or larger-scale research efforts, and an R43/R44 version (RFA-HG-09-013) aligned with the Small Business Innovation Research/Small Business Technology Transfer pathways. That parallel structure reflects NHGRI's intent to support innovation across different stages of readiness and across both academic and commercial development tracks.
For applicants seeking full details, the notice points to the NIH Grants Guide page for the official announcement (http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-09-012.html). For access or technical issues related to the announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
1) What is the name of this funding opportunity?
The opportunity is titled "Revolutionary Genome Sequencing Technologies: The 1000 Genome (R21)".
2) What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-HG-09-012.
3) Which NIH Institute is offering this solicitation?
This is an NIH solicitation from the National Human Genome Research Institute (NHGRI).
4) What is the main goal of the program?
The central goal is to drive breakthroughs in DNA sequencing technology that dramatically lower cost while maintaining high data quality, with an ambitious target of making it feasible to sequence a mammalian-sized genome for about $1,000.
5) Is this opportunity focused on incremental improvements or breakthrough technology development?
It is explicitly oriented toward technology development rather than incremental improvement, with an emphasis on ideas that could materially change the economics and scalability of genome sequencing.
6) What grant mechanism does this FOA use?
This FOA uses the NIH Exploratory/Developmental Research Grant (R21) mechanism.
7) What types of projects does the R21 mechanism typically support in this context?
As described, the R21 mechanism is commonly used for early-stage, high-risk projects that may not yet have extensive preliminary data but have strong potential for major impact.
8) What kinds of applications are invited under this solicitation?
Applicants are invited to propose either:
- Complete end-to-end sequencing platforms, or
- Focused projects that tackle major technical barriers within critical components of sequencing systems.
9) Can an applicant focus on only one component of a sequencing system?
Yes. The solicitation is open to focused projects aimed at solving key enabling problems within critical components of sequencing systems.
10) What examples of sequencing system components or barriers are mentioned?
The examples provided include projects addressing chemistry, detection methods, sample preparation, signal processing, throughput, error correction, or other fundamental hurdles that limit cost and quality.
11) Does NHGRI encourage high-risk approaches?
Yes. The notice explicitly encourages "high risk/high payoff" proposals and signals interest in genuinely novel ideas, including approaches beyond mainstream strategies being pursued at the time.
12) What timeline goal is referenced for progress toward the $1,000 genome?
The notice mentions a timeline goal of helping drive progress toward the $1,000 genome objective by around 2014.
13) What is the CFDA number and program area associated with this opportunity?
The opportunity is listed under CFDA 93.172, Human Genome Research, and is categorized as a discretionary grant in the health domain.
14) Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching.
15) When was the opportunity posted?
The posting date is July 17, 2009.
16) What is the application closing date?
The application closing date listed is October 19, 2009.
17) What is the archive date for this announcement?
The archive date is November 19, 2009.
18) How many awards did NHGRI anticipate making?
NHGRI anticipated making roughly 2 to 7 awards, depending on the availability of funds and the quality of applications received.
19) What is the estimated total funding level for this FOA?
The estimated total funding level listed is $2,000,000 in total costs for FY2010, with the notice indicating a similar amount again in FY2011 in response to the FOA.
20) What is the award ceiling shown in the record?
The award ceiling shown in the record is $200,000, reflecting the smaller, exploratory nature typical of R21 awards.
21) Who is eligible to apply?
Eligibility is broad and includes multiple organization types across academia, government, and industry, including:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations (including 501(c)(3) nonprofits and certain nonprofits without 501(c)(3) status)
- For-profit organizations (other than small businesses)
- Small businesses
- State governments
22) Are federal agencies eligible to apply?
Yes. The eligibility text notes additional eligible applicants such as federal government agencies.
23) Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligibility text indicates that non-U.S. entities (foreign organizations) are eligible, meaning participation was not limited strictly to domestic institutions.
24) Are there related funding opportunities with the same scientific scope but different mechanisms?
Yes. This R21 solicitation was designed to run in parallel with:
- An R01 version: RFA-HG-09-011
- An R43/R44 version aligned with SBIR/STTR pathways: RFA-HG-09-013
25) Why are there parallel FOAs (R21, R01, and R43/R44) for the same scientific area?
Based on the description provided, the parallel structure reflects NHGRI's intent to support innovation across different stages of readiness and across both academic and commercial development tracks.
26) Where can applicants find the official announcement?
The notice points to the NIH Grants Guide page for the official announcement here:
http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-09-012.html
27) Who should be contacted for access or technical issues related to the announcement?
For access or technical issues, the listed contact is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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