Opportunity Information: Apply for RFA HG 10 014
Apply for RFA HG 10 014
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Revolutionary Genome Sequencing Technologies The 1000 Genome (SBIR R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Aug 27, 2010 and posted on Aug 27, 2010.
- Applicants must submit their applications by Oct 17, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Eligible applicants include: Small businesses.
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Opportunity Summary:
This funding opportunity, titled "Revolutionary Genome Sequencing Technologies: The 1000 Genome (SBIR R43/R44)" (Funding Opportunity Number RFA-HG-10-014), is a National Institutes of Health program run through the National Human Genome Research Institute (NHGRI) aimed at pushing DNA sequencing into a new cost and performance tier. The central purpose is to stimulate the development of truly novel sequencing technologies that can deliver extremely low-cost, high-quality DNA sequencing, with a headline target of bringing the cost of sequencing a mammalian-sized genome down to about $1,000. The solicitation is framed around the idea that reaching this price point will require approaches that go beyond incremental improvements and instead rely on breakthroughs in technology, chemistry, physics, engineering, computation, or integrated system design.
The opportunity is specifically set up for small businesses through the Small Business Innovation Research (SBIR) program, using the NIH R43/R44 mechanisms. That means applicants can propose Phase I projects (typically proof-of-concept and early feasibility), Phase II projects (development, optimization, and validation toward a product), or Fast-Track applications that combine Phase I and Phase II into a single application to accelerate progress. NHGRI makes clear that applicants can either propose complete, end-to-end sequencing platforms or focus on critical barriers within key components of a sequencing system. In practice, that leaves room for a wide range of project types, such as new sequencing chemistries, new detection modalities, improved sample preparation approaches, novel single-molecule methods, advances in nanopore or other nontraditional strategies, improved accuracy or throughput solutions, and enabling hardware/software that materially changes the cost curve.
A notable feature of the announcement is its explicit encouragement of ideas that are not the mainstream approaches already being heavily pursued in the field. The program is designed to create space for unconventional concepts that may be considered high risk but have the potential for high payoff if they succeed. The FOA also signals a sense of urgency and a clear outcome-driven timeline, stating that high risk/high payoff proposals are appropriate in order to achieve the goals of the funding opportunity by around 2014. In other words, this is not just basic research for its own sake; it is intended to catalyze tangible technology progress toward a specific, ambitious cost and quality target.
On the funding side, NHGRI estimated approximately $2.5 million in total funding available for fiscal year 2011 to support an anticipated 25 projects awarded under this announcement, with the caveat that future-year funding levels would depend on annual appropriations. There is no cost-sharing or matching requirement, which is consistent with typical NIH SBIR awards. The opportunity is categorized as discretionary, uses the grant funding instrument, falls under the health funding activity category, and is associated with CFDA number 93.172 (Human Genome Research). Eligibility is limited to small businesses, aligning with SBIR program rules.
The announcement also notes that it runs in parallel with two related funding opportunity announcements with identical scientific scope, RFA-HG-10-012 and RFA-HG-10-013, which solicit applications under the R01 and R21 mechanisms. The practical takeaway is that NHGRI was supporting the same overarching scientific push across both small business and traditional academic/research pathways, allowing innovations to emerge from startups as well as universities and research institutions, but with this particular FOA reserved for SBIR-eligible companies.
Key administrative dates listed for the FOA include a posted/creation date of August 27, 2010, an original and current closing date of October 17, 2012, and an archive date of November 17, 2012, indicating that this was a time-bounded initiative with a defined submission window. For official details, the full announcement was hosted through the NIH Grants Guide, and the contact listed for technical access issues was the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "Revolutionary Genome Sequencing Technologies: The 1000 Genome (SBIR R43/R44)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-HG-10-014.
Which agency and institute are running this program?
This is a National Institutes of Health (NIH) program run through the National Human Genome Research Institute (NHGRI).
What is the main purpose of the grant?
The central purpose is to stimulate the development of truly novel DNA sequencing technologies that can deliver extremely low-cost, high-quality DNA sequencing, with a headline target of reducing the cost to sequence a mammalian-sized genome to about $1,000.
What makes this opportunity different from typical technology-improvement grants?
The solicitation is explicitly framed around the idea that reaching the $1,000 genome price point will require approaches beyond incremental improvements. It emphasizes breakthroughs in areas like technology, chemistry, physics, engineering, computation, or integrated system design.
Who is eligible to apply?
Eligibility is limited to small businesses, consistent with the Small Business Innovation Research (SBIR) program rules.
What funding mechanisms does this SBIR opportunity use?
The program uses NIH SBIR mechanisms R43/R44.
What types of SBIR applications can be submitted under this FOA?
Applicants can propose Phase I projects, Phase II projects, or Fast-Track applications that combine Phase I and Phase II into a single application.
What is the difference between Phase I, Phase II, and Fast-Track in this announcement?
Phase I is described as typically focusing on proof-of-concept and early feasibility. Phase II is described as focusing on development, optimization, and validation toward a product. Fast-Track combines Phase I and Phase II into one application to accelerate progress.
Do applicants need to propose a full sequencing platform?
No. NHGRI indicates applicants can propose complete, end-to-end sequencing platforms or focus on critical barriers within key components of a sequencing system.
What kinds of project topics are considered in scope?
The announcement leaves room for a wide range of project types, including new sequencing chemistries, new detection modalities, improved sample preparation approaches, novel single-molecule methods, advances in nanopore or other nontraditional strategies, improved accuracy or throughput solutions, and enabling hardware/software that materially changes the cost curve.
Does the FOA encourage unconventional or high-risk ideas?
Yes. A notable feature is explicit encouragement of ideas that are not the mainstream approaches already being heavily pursued. The program is designed to create space for unconventional concepts that may be considered high risk but have the potential for high payoff.
Is this funding focused on basic research or tangible technology outcomes?
It is presented as outcome-driven and aimed at catalyzing tangible technology progress toward a specific, ambitious cost and quality target rather than basic research for its own sake.
Is there an expected timeline for achieving the program goals?
The FOA signals urgency and indicates that high risk/high payoff proposals are appropriate to achieve the goals of the funding opportunity by around 2014.
How much total funding was estimated to be available?
NHGRI estimated approximately $2.5 million in total funding available for fiscal year 2011 under this announcement.
How many awards were anticipated?
The announcement anticipated about 25 projects awarded under this FOA.
Is future-year funding guaranteed?
No. The announcement notes that future-year funding levels would depend on annual appropriations.
Is cost-sharing or matching required?
No. The opportunity states there is no cost-sharing or matching requirement.
What type of funding instrument is used?
This opportunity uses the grant funding instrument.
How is the opportunity categorized in terms of funding activity?
It is categorized as discretionary, uses a grant funding instrument, and falls under the health funding activity category.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA 93.172 (Human Genome Research).
Are there related funding opportunities with the same scientific scope?
Yes. The announcement runs in parallel with two related FOAs with identical scientific scope: RFA-HG-10-012 and RFA-HG-10-013, which solicit applications under the R01 and R21 mechanisms.
What is the practical difference between this FOA and the related R01/R21 FOAs?
This FOA is reserved for SBIR-eligible small businesses using the R43/R44 mechanisms, while the related announcements support the same overall scientific push through traditional research pathways using R01 and R21 mechanisms.
When was this FOA posted?
The posted/creation date listed is August 27, 2010.
What was the closing date for submissions?
The original and current closing date listed is October 17, 2012.
When was the FOA archived?
The archive date listed is November 17, 2012.
Where were the official details posted?
The full announcement was hosted through the NIH Grants Guide.
Who is listed as the contact for technical access issues?
The contact listed for technical access issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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