Opportunity Information: Apply for PA 11 121
Apply for PA 11 121
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Ribosomal Disorders and Their Role in Inherited Bone Marrow Failure Syndromes (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Feb 14, 2011 and posted on Feb 14, 2011.
- Applicants must submit their applications by May 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Private institutions of higher education Public and State controlled institutions of higher education County governments City or township governments For profit organizations other than small businesses Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity titled "Ribosomal Disorders and Their Role in Inherited Bone Marrow Failure Syndromes (R01)" (Funding Opportunity Number PA 11-121) is an NIH discretionary research grant aimed at advancing what is known about how ribosomal dysfunction contributes to inherited bone marrow failure syndromes. It is jointly issued by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The central scientific goal is to push forward molecular and cellular understanding of ribosome-related disease mechanisms, with particular emphasis on how defects in ribosome biology affect hematopoiesis (the formation of blood cells) and how those defects can lead to bone marrow failure. A key theme running through the announcement is that progress in this area depends on research that connects fundamental ribosomal biology with clinically relevant questions about marrow failure syndromes, rather than treating them as separate domains.
This FOA explicitly encourages collaborative projects conducted by multidisciplinary teams, bringing together complementary expertise across basic and clinical components. In practice, that means proposals are expected to integrate perspectives and methods that can span ribosome structure and function, gene regulation, cell stress responses, stem and progenitor cell biology, and clinical investigation of inherited marrow failure conditions. The intent is not simply to catalog genetic variants or describe phenotypes, but to drill down into mechanism: how specific disruptions in ribosome biogenesis, assembly, or function translate into altered cell fate decisions, impaired proliferation or differentiation, and ultimately defective blood production. By promoting team science, the FOA signals that strong applications will often combine multiple approaches, such as mechanistic studies in cells, in vivo modeling, and clinically informed analyses that keep the disease context front and center.
A major objective highlighted in the description is the development and characterization of models of ribosomopathies, specifically in ways that directly connect ribosomal dysfunction to bone marrow failure. Applicants are encouraged to build and use experimental models that can test mechanistic hypotheses and clarify causal pathways. While the announcement summary does not dictate particular model systems, its emphasis on integration suggests a preference for models that can bridge levels of biology, for example linking molecular defects in ribosome production or function to cellular consequences in hematopoietic stem and progenitor compartments, and then to organism-level outcomes relevant to inherited marrow failure syndromes. The overall direction is translational in the broad sense: not necessarily focused on an immediate therapeutic product, but designed to produce mechanistic insights that can eventually inform diagnosis, risk assessment, and treatment strategies.
From an administrative standpoint, this is an R01 research project grant within the NIH health funding activity category, listed under CFDA number 93.839 (Blood Diseases and Resources Research). The opportunity does not require cost sharing or matching. It was posted and created on February 14, 2011, with an original and current closing date of May 7, 2014, and it was archived on June 7, 2014, meaning it is no longer open for new applications under this specific announcement, but it remains a useful reference for the NIH priorities and expectations in this scientific area.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (both with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations other than small businesses, and small businesses. Government entities are also listed as eligible, including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA further clarifies that additional eligible applicants include Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), tribal governments and tribal organizations (including those other than federally recognized), faith-based or community-based organizations, U.S. territories or possessions, regional organizations, eligible federal agencies, and foreign (non-U.S.) entities. This wide eligibility scope reinforces the FOA's emphasis on assembling the strongest possible scientific teams and resources, regardless of institutional type, and it leaves room for international expertise where it strengthens the research.
For applicants seeking the full historical text of the announcement, the additional information link provided is http://grants.nih.gov/grants/guide/pa-files/PA-11-121.html. For technical issues accessing the announcement or linking problems, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The funding opportunity is titled "Ribosomal Disorders and Their Role in Inherited Bone Marrow Failure Syndromes (R01)" and the Funding Opportunity Number is PA 11-121.
Which agencies issued this funding opportunity?
This FOA was jointly issued by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), both within the National Institutes of Health (NIH).
What type of grant mechanism is this?
This opportunity uses the NIH R01 research project grant mechanism.
What is the main scientific purpose of this FOA?
The central goal is to advance molecular and cellular understanding of how ribosomal dysfunction contributes to inherited bone marrow failure syndromes, with a particular emphasis on how defects in ribosome biology affect hematopoiesis (blood cell formation) and lead to bone marrow failure.
What kinds of research themes are emphasized?
The FOA emphasizes research that connects fundamental ribosomal biology with clinically relevant questions about inherited marrow failure syndromes. It encourages mechanistic work explaining how disruptions in ribosome biogenesis, assembly, or function translate into altered cell fate decisions, impaired proliferation or differentiation, and defective blood production.
Does the FOA emphasize mechanistic research or descriptive studies?
The FOA emphasizes mechanism. It indicates the intent is not simply to catalog genetic variants or describe phenotypes, but to drill down into causal pathways linking specific ribosomal defects to hematopoietic consequences and bone marrow failure.
Is collaboration encouraged?
Yes. The FOA explicitly encourages collaborative projects conducted by multidisciplinary teams, integrating complementary basic and clinical expertise.
What kinds of expertise are applicants expected to integrate?
The FOA describes proposals as expected to span and integrate areas such as ribosome structure and function, gene regulation, cell stress responses, stem and progenitor cell biology, and clinical investigation of inherited marrow failure conditions.
Are experimental models part of the FOA objectives?
Yes. A major objective highlighted is the development and characterization of models of ribosomopathies in ways that directly connect ribosomal dysfunction to bone marrow failure.
Does the FOA specify which model systems must be used?
No specific model systems are dictated in the provided summary. However, the FOA emphasizes integration and suggests a preference for models that bridge levels of biology (molecular defects to cellular consequences in hematopoietic stem/progenitor compartments to organism-level outcomes relevant to inherited marrow failure syndromes).
Is the research expected to be translational?
Yes, in a broad sense. The direction is described as translational by aiming to produce mechanistic insights that can eventually inform diagnosis, risk assessment, and treatment strategies, even if not focused on an immediate therapeutic product.
What is the CFDA number and program area listed for this opportunity?
The opportunity is listed under CFDA number 93.839, identified as Blood Diseases and Resources Research.
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching is not required.
When was this opportunity posted, and what were the closing dates?
It was posted and created on February 14, 2011. The original and current closing date listed is May 7, 2014.
Is this funding opportunity still open?
No. It was archived on June 7, 2014, which indicates it is no longer open for new applications under this specific announcement. The archived FOA may still be useful as a reference for NIH priorities and expectations in this scientific area.
Who is eligible to apply?
Eligibility is broad and includes many domestic and non-domestic organizations. Eligible applicants include public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status, other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and multiple government entities.
Which government entities are listed as eligible applicants?
Eligible government entities include state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are tribal, territorial, or community-based organizations included in the eligibility list?
Yes. The FOA lists tribal governments and tribal organizations (including those other than federally recognized), U.S. territories or possessions, and faith-based or community-based organizations as eligible applicants.
Are specific types of minority-serving institutions included?
Yes. The eligibility list includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are foreign (non-U.S.) organizations eligible?
Yes. The FOA states that foreign (non-U.S.) entities are eligible.
Where can applicants find the full historical text of the announcement?
The additional information link provided for the full FOA text is: http://grants.nih.gov/grants/guide/pa-files/PA-11-121.html.
Who should be contacted for technical issues accessing the announcement?
For technical issues or linking problems, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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