Opportunity Information: Apply for RFA RM 09 022
Apply for RFA RM 09 022
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Roadmap Transformative Research Projects Program (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Oct 23, 2009 and posted on Oct 23, 2009.
- Applicants must submit their applications by Jan 22, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses Special district governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments State governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Independent school districts Private institutions of higher education County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Roadmap Transformative Research Projects Program (R01) is a National Institutes of Health (NIH) funding opportunity under the NIH Roadmap for Biomedical Research that is designed to support research ideas that are truly unconventional and potentially field-changing. The central aim is to fund projects that are exceptionally innovative, high-risk, and original, including work that may challenge established theories, overturn standard approaches, or create entirely new scientific paradigms. Unlike many programs that prioritize strong preliminary data and incremental advances, this program is geared toward bold concepts where the payoff could be very large, provided the application makes a convincing case that the work could have major impact across a broad area of biomedical or behavioral research.
The funding mechanism used is the standard NIH Research Project Grant (R01), meaning applicants propose a defined research plan with clear objectives, a project narrative, and a budget consistent with R01 expectations. Even though the mechanism is a familiar R01, the spirit of the program is distinct: NIH is explicitly inviting applications that may seem risky or unconventional as long as they are grounded in strong rationale and have the potential to shift how a problem is understood or solved. Awards are expected to go to the most meritorious projects, with the final number of funded awards depending on both the overall quality of applications and the proposed budgets and scopes.
For fiscal year 2010, the NIH Common Fund planned to commit approximately 25 million dollars to this program. Because the number of awards is not fixed, applicants are effectively competing not only on scientific merit but also on how compelling and scalable their proposed work is relative to the overall funding pool. The opportunity is categorized as discretionary, and the funding instrument type is a grant. It falls under the health funding activity category and is associated with CFDA number 93.310 (Trans-NIH Research Support). There is no cost sharing or matching requirement, which reduces barriers for organizations that might not have substantial non-federal funds available.
Eligibility is broad and spans many organization types, reflecting NIH interest in transformative ideas regardless of institutional setting. Eligible applicants include small businesses; for-profit organizations (other than small businesses); nonprofit organizations with and without 501(c)(3) status; public and private institutions of higher education; public and state-controlled institutions of higher education; state, county, city/township governments; independent school districts; special district governments; public housing authorities and Indian housing authorities; Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments); and a wide range of other entities noted in the eligibility information. Additional eligible applicants explicitly include Alaska Native and Native Hawaiian Serving Institutions, Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and non-U.S. entities (foreign organizations). This wide eligibility signals that NIH is open to transformative contributions from diverse sectors and geographies, including international organizations when appropriate.
Key administrative details for this announcement include the funding opportunity number RFA-RM-09-022 and the title Roadmap Transformative Research Projects Program (R01). The opportunity was posted and created on October 23, 2009, with an original and current closing date of January 22, 2010, and an archive date of February 22, 2010. The sponsoring agency is the National Institutes of Health. The full announcement was made available through the NIH grants guide, and support contacts were provided through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
Overall, this program is best understood as an R01 route specifically carved out for high-impact, paradigm-shifting science. Successful applications would be expected to articulate a clear and daring scientific vision, explain why the approach is transformative rather than incremental, and demonstrate credible potential to influence a broad biomedical or behavioral research area, even if the work carries substantial uncertainty.
Frequently Asked Questions (FAQ)
What is the Roadmap Transformative Research Projects Program (R01)?
The Roadmap Transformative Research Projects Program (R01) is a National Institutes of Health (NIH) funding opportunity under the NIH Roadmap for Biomedical Research. It is designed to support research ideas that are truly unconventional and potentially field-changing, with the goal of enabling major shifts in biomedical or behavioral research.
What is the main goal of this program?
The central aim is to fund projects that are exceptionally innovative, high-risk, and original, including research that may challenge established theories, overturn standard approaches, or create entirely new scientific paradigms. The program is focused on bold concepts where the potential payoff could be very large.
How is this program different from typical NIH funding opportunities?
Unlike many programs that prioritize strong preliminary data and incremental progress, this opportunity explicitly invites applications that may seem risky or unconventional. The key expectation is that the application provides a strong rationale and a convincing case that the work could have major impact across a broad area of biomedical or behavioral research.
What funding mechanism does this opportunity use?
This opportunity uses the standard NIH Research Project Grant (R01) mechanism. Applicants propose a defined research plan with clear objectives, a project narrative, and a budget consistent with R01 expectations.
Does using the R01 mechanism mean the research should be conventional?
No. Even though the mechanism is a familiar R01, the spirit of the program is distinct. NIH is explicitly inviting high-risk, unconventional, and potentially paradigm-shifting science, as long as it is grounded in strong rationale and has credible potential for broad impact.
What kinds of research projects are a good fit for this program?
Projects are a strong fit if they are exceptionally innovative and original, and if they could change how a problem is understood or solved. Examples of the type of work described include research that challenges established theories, overturns standard approaches, or introduces entirely new paradigms in biomedical or behavioral research.
Is preliminary data required?
The program is described as being geared toward bold concepts rather than emphasizing strong preliminary data and incremental advances. The application still needs to make a convincing case for why the approach is credible and potentially transformative based on its rationale and expected impact.
How are awards determined?
Awards are expected to go to the most meritorious projects. The final number of funded awards is not fixed and depends on the overall quality of applications as well as the proposed budgets and scopes.
Is the number of awards fixed?
No. The number of awards is not fixed. Funding decisions depend on scientific merit and on how proposed budgets and project scopes fit within the overall funding pool.
How much funding was planned for this program?
For fiscal year 2010, the NIH Common Fund planned to commit approximately $25 million to this program.
What does it mean that applicants compete relative to the overall funding pool?
Because the number of awards is not set, applicants are competing not only on scientific merit but also on how compelling and scalable their proposed work is relative to the available program funds and the proposed budgets and scopes submitted by all applicants.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement for this opportunity.
What is the funding instrument type and activity category?
The funding instrument type is a grant, and it falls under the health funding activity category. The opportunity is categorized as discretionary.
What is the CFDA number associated with this opportunity?
This opportunity is associated with CFDA number 93.310 (Trans-NIH Research Support).
Who is eligible to apply?
Eligibility is broad and includes many organization types. Eligible applicants include small businesses; for-profit organizations (other than small businesses); nonprofit organizations with and without 501(c)(3) status; public and private institutions of higher education; public and state-controlled institutions of higher education; state, county, and city/township governments; independent school districts; special district governments; public housing authorities and Indian housing authorities; Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments); and other entities referenced in the eligibility information.
Are minority-serving and community-based institutions eligible?
Yes. Additional eligible applicants explicitly include Alaska Native and Native Hawaiian Serving Institutions, Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and faith-based and community-based organizations.
Are U.S. government entities eligible?
Yes. Eligibility includes state, county, and city/township governments, as well as independent school districts and special district governments. Eligible federal agencies are also explicitly listed among additional eligible applicants.
Are U.S. territories and regional organizations eligible?
Yes. Additional eligible applicants explicitly include U.S. territories or possessions and regional organizations.
Are non-U.S. (foreign) organizations eligible?
Yes. Non-U.S. entities (foreign organizations) are explicitly included in the eligibility information.
What is the funding opportunity number and title?
The funding opportunity number is RFA-RM-09-022, and the title is Roadmap Transformative Research Projects Program (R01).
When was this opportunity posted, and what were the key dates?
The opportunity was posted and created on October 23, 2009. The original and current closing date was January 22, 2010. The archive date was February 22, 2010.
Which agency sponsors this funding opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
Where was the full announcement made available?
The full announcement was made available through the NIH grants guide.
Who should be contacted for access or linking issues related to the announcement?
Support contacts were provided through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
What should a strong application emphasize for this program?
Successful applications would be expected to articulate a clear and daring scientific vision, explain why the approach is transformative rather than incremental, and demonstrate credible potential to influence a broad biomedical or behavioral research area, even if substantial uncertainty is involved.
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