Opportunity Information: Apply for PA 16 145
Apply for PA 16 145
- The HHS-NIH11 in the education, health sector is offering a public funding opportunity titled "Role of Astrocytes and Astrocytic Networks in Drug Abuse (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on Mar 22, 2016 and posted on Mar 22, 2016.
- Applicants must submit their applications by May 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The funding opportunity titled "Role of Astrocytes and Astrocytic Networks in Drug Abuse (R21)" (Funding Opportunity Number PA 16-145) is a discretionary NIH grant program from HHS (Agency: HHS-NIH11) focused on advancing research into how drugs of abuse affect astrocytes and, more specifically, the networked organization of astrocytes in the central nervous system. While astrocytes are increasingly recognized as active participants in brain signaling and circuit regulation rather than passive support cells, the FOA highlights a major gap: comparatively little is known about how addictive drugs reshape the structural connectivity of astrocytic networks and alter the way information is generated, processed, and controlled across these networks over time and space. The central goal is to stimulate studies that directly interrogate drug-induced changes in astrocyte-to-astrocyte organization and communication patterns, and how those changes may contribute to addiction-relevant brain function and dysfunction.
This announcement uses the NIH R21 mechanism, which is typically intended for exploratory, early-stage, or high-risk/high-reward projects that can open new lines of investigation. The FOA is aimed at projects that examine (1) the effects of drugs of abuse on the structural organization and connectivity of astrocytic networks within the CNS and (2) the dynamics of astrocytic network activity, including how activity arises, propagates, and is regulated with precise spatiotemporal properties. In practical terms, the research encouraged here would likely involve approaches capable of measuring network structure (for example, mapping astrocyte contacts, coupling, or connectivity patterns) and network function (for example, imaging or recording astrocytic activity patterns and their timing, spread, and coordination), particularly in contexts relevant to substance use and addiction neurobiology.
The program falls under CFDA number 93.279 and is categorized under Education and Health in the funding activity classification, reflecting NIHs biomedical research mission. A key administrative detail is the listed award ceiling of $200,000, indicating the maximum funding level specified in the opportunity details (commonly interpreted within the constraints and norms of the R21 mechanism). The opportunity was created and posted on March 22, 2016, and the closing date provided is May 7, 2019, meaning it was time-limited with that final submission deadline as stated in the source data.
Eligibility is broad and includes a wide range of applicant organizations. Eligible applicants include public sector entities such as state governments, county governments, city or township governments, special district governments, and independent school districts, as well as public and state-controlled institutions of higher education. It also includes Native American tribal governments (federally recognized) and other Native American tribal organizations, public housing authorities/Indian housing authorities, and a variety of nonprofit organizations both with and without 501(c)(3) status (as long as they are not institutions of higher education, per the listing). Private institutions of higher education are eligible, along with for-profit organizations (other than small businesses) and small businesses. The listing also includes an "Others" category with a note to consult the FOA text for additional eligibility clarification, suggesting that the full announcement may specify additional conditions or allowable applicant types.
Overall, this FOA is essentially a targeted call for innovative neuroscience and addiction-related research that treats astrocytes as networked information-processing elements whose structure and activity patterns may be altered by drugs of abuse. By emphasizing structural connectivity and spatiotemporal control of astrocytic activity, the opportunity is designed to push beyond traditional neuron-centered models of addiction and encourage mechanistic studies that could reveal new cellular or circuit-level pathways involved in substance use disorders.
FAQs: Role of Astrocytes and Astrocytic Networks in Drug Abuse (R21) - PA 16-145
What is the title of this funding opportunity?
The opportunity is titled "Role of Astrocytes and Astrocytic Networks in Drug Abuse (R21)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PA 16-145.
Which agency is offering this grant?
This is a discretionary NIH grant program under the U.S. Department of Health and Human Services (HHS), specifically listed as HHS-NIH11.
What grant mechanism does this announcement use?
The announcement uses the NIH R21 mechanism.
What is the purpose of the R21 mechanism in this program?
In this context, the R21 mechanism is described as supporting exploratory, early-stage, or high-risk/high-reward projects intended to open new lines of investigation.
What is the main scientific focus of the FOA?
The FOA focuses on advancing research into how drugs of abuse affect astrocytes, with a particular emphasis on the networked organization of astrocytes in the central nervous system (CNS).
Why does this FOA emphasize astrocytes and astrocytic networks?
The FOA highlights that astrocytes are increasingly recognized as active participants in brain signaling and circuit regulation, not just passive support cells. It also notes a major knowledge gap: comparatively little is known about how addictive drugs reshape the structural connectivity of astrocytic networks and how information is generated, processed, and controlled across these networks over time and space.
What gap in knowledge is this funding opportunity trying to address?
It targets the gap in understanding of (1) how drugs of abuse alter astrocyte-to-astrocyte structural organization and connectivity in the CNS and (2) how drugs affect the dynamics of astrocytic network activity, including spatiotemporal patterns of activity generation, propagation, and regulation.
What types of research topics are encouraged?
The FOA encourages projects that directly interrogate drug-induced changes in astrocyte-to-astrocyte organization and communication patterns, and that examine how those changes may contribute to addiction-relevant brain function and dysfunction.
What are the two main areas of investigation specified in the FOA?
The FOA is aimed at projects that examine: (1) the effects of drugs of abuse on the structural organization and connectivity of astrocytic networks within the CNS; and (2) the dynamics of astrocytic network activity, including how activity arises, propagates, and is regulated with precise spatiotemporal properties.
What does the FOA mean by "astrocytic network activity" and "spatiotemporal properties"?
Based on the description provided, this refers to how astrocyte activity is generated, how it spreads or propagates through networks, how coordinated it is, and how it is controlled across both space (where activity occurs and spreads) and time (when it occurs, its timing, and its dynamics).
What kinds of approaches might be relevant to the research aims described?
The opportunity description suggests approaches capable of measuring network structure (for example, mapping astrocyte contacts, coupling, or connectivity patterns) and network function (for example, imaging or recording astrocytic activity patterns and their timing, spread, and coordination), particularly in contexts relevant to substance use and addiction neurobiology.
Is this opportunity focused on the central nervous system (CNS)?
Yes. The FOA specifically emphasizes astrocytic networks within the CNS.
How is this opportunity categorized in funding activity classification?
It is categorized under Education and Health in the funding activity classification.
What is the CFDA number for this program?
The CFDA number listed is 93.279.
What is the maximum award amount mentioned in the opportunity details?
The listed award ceiling is $200,000, described as the maximum funding level specified in the opportunity details (commonly interpreted within the constraints and norms of the R21 mechanism).
When was this funding opportunity created and posted?
The opportunity was created and posted on March 22, 2016.
What is the closing date (deadline) listed for this opportunity?
The closing date provided is May 7, 2019.
Is this a time-limited opportunity based on the provided dates?
Yes. Based on the information provided, it was time-limited with a final submission deadline of May 7, 2019.
Who is eligible to apply?
Eligibility is described as broad and includes many applicant organization types, including public sector entities, education institutions, tribal entities, nonprofits, and for-profit organizations, among others.
Are state governments eligible?
Yes. State governments are listed as eligible applicants.
Are local governments eligible (county, city, township, special districts)?
Yes. County governments, city or township governments, and special district governments are listed as eligible.
Are independent school districts eligible?
Yes. Independent school districts are listed as eligible applicants.
Are public and state-controlled institutions of higher education eligible?
Yes. Public and state-controlled institutions of higher education are listed as eligible.
Are private institutions of higher education eligible?
Yes. Private institutions of higher education are listed as eligible.
Are Native American tribal governments eligible?
Yes. Native American tribal governments (federally recognized) are listed as eligible applicants.
Are other Native American tribal organizations eligible?
Yes. Other Native American tribal organizations are included in the eligibility listing.
Are public housing authorities/Indian housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible applicants.
Are nonprofit organizations eligible?
Yes. The listing includes nonprofit organizations with 501(c)(3) status and nonprofit organizations without 501(c)(3) status, with the noted condition that they are not institutions of higher education (per the listing).
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed as eligible.
Does the listing mention any additional eligibility clarification?
Yes. The eligibility section includes an "Others" category with a note to consult the FOA text for additional eligibility clarification, suggesting the full announcement may specify additional conditions or allowable applicant types.
What kind of research impact is this FOA trying to achieve?
The FOA is designed to push beyond traditional neuron-centered models of addiction by encouraging mechanistic studies of astrocytes as networked information-processing elements, with the goal of revealing new cellular or circuit-level pathways involved in substance use disorders.
Does the FOA focus on addiction-relevant brain function and dysfunction?
Yes. The description states that the goal is to understand how drug-induced changes in astrocytic organization and communication patterns may contribute to addiction-relevant brain function and dysfunction.
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| Population Health Interventions: Integrating Individual and Group Level Evidence (R01) Apply for PA 16 146 Funding Number: PA 16 146 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Role of Astrocytes and Astrocytic Networks in Drug Abuse (R01) Apply for PA 16 144 Funding Number: PA 16 144 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Revision Applications to R01 Awards for Research on the NCI's Provocative Questions (R01) Apply for RFA CA 16 010 Funding Number: RFA CA 16 010 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $150,000 |
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| Improving Smoking Cessation in Socioeconomically Disadvantaged Populations via Scalable Interventions (R01) Apply for PAR 16 202 Funding Number: PAR 16 202 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
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