Opportunity Information: Apply for PA 15 169
Apply for PA 15 169
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Apr 1, 2015 and posted on Apr 1, 2015.
- Applicants must submit their applications by May 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) City or township governments Public and State controlled institutions of higher education State governments Public housing authorities/Indian housing authorities Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity "Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21)" (Funding Opportunity Number PA 15-169) is a National Institutes of Health (NIH) discretionary grant program designed to support short, exploratory research projects that rely on secondary analysis of existing data rather than collecting new primary data. It uses the NIH R21 mechanism, which is typically geared toward early-stage, innovative, or high-risk/high-reward ideas that can be tested relatively quickly. In this case, the central purpose is to help researchers ask fresh, creative questions using datasets that already exist, enabling new discoveries without the time and cost of building cohorts or launching new data collection.
The scientific scope is broad but clearly anchored in diseases and biological systems commonly supported by NIH work in diabetes, digestive diseases, and kidney-related conditions. The FOA specifically encourages projects that reanalyze existing datasets relevant to diabetes and a range of endocrine and metabolic diseases, including thyroid and parathyroid disorders, Cushing's disease, and acromegaly. It also extends to genetic and metabolic diseases such as cystic fibrosis, lysosomal storage diseases, and disorders involving the urea cycle, amino acid metabolism, and metal transport, particularly where the research emphasis is on peripheral metabolism or organ function. Beyond endocrine and inherited metabolic conditions, the FOA also covers obesity; liver diseases; diseases of the alimentary gastrointestinal (GI) tract; nutrition-related research; and kidney, urologic, and hematologic diseases. In practical terms, this means an applicant could leverage clinical trial datasets, epidemiologic cohorts, electronic health record-derived datasets, disease registries, biobank-linked phenotypic datasets, or other well-characterized existing resources to test new hypotheses, examine subgroups, identify predictors, explore mechanisms, or refine phenotypes.
The overarching goal is to facilitate research that explores innovative hypotheses through use of existing data sets. This emphasis matters because it signals what reviewers are likely to value: novelty in the question being asked, strong justification for why the existing dataset is appropriate, and rigorous analytic methods that can credibly generate new insights. The program is not simply about re-running standard analyses; it is meant to promote creative, well-reasoned secondary research that gets more scientific value out of prior investments in data collection. Projects might include, for example, investigating under-studied endpoints already captured in legacy datasets, testing new conceptual models, applying modern statistical or computational approaches to older datasets, or harmonizing variables across multiple datasets to address questions that a single study could not resolve. While the FOA text provided does not list specific methodological requirements, the nature of secondary analysis programs typically implies careful attention to data quality, variable definitions, missingness, bias/confounding, and whether the dataset truly supports the proposed inferences.
From an administrative standpoint, this is a grant (Funding Instrument Type: Grant) in the "Food and Nutrition" and "Health" activity categories, with CFDA number 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). There is no cost sharing or matching requirement, which means applicants are not required to provide institutional matching funds as a condition of eligibility. The award ceiling listed is $200,000, indicating the maximum budget level referenced in the summary information provided. As an R21 opportunity, awards are generally intended to be smaller and shorter-term than large research project grants, aligning with the exploratory nature of the work and the fact that data collection is not the focus.
Eligibility is expansive and includes a wide range of organization types. Eligible applicants include public and private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations other than small businesses, small businesses, and multiple levels of government (state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities). It also includes Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments). The "other eligible applicants" category further notes Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and importantly, non-domestic entities (foreign organizations). That broad eligibility suggests NIH intended this FOA to be accessible to many sectors that may have relevant analytic expertise and access to important datasets, not solely traditional academic biomedical departments.
In terms of timeline, the FOA was posted and created on April 1, 2015. The original and current closing date listed is May 7, 2018, and it was archived on June 7, 2018, meaning the opportunity is no longer open for applications under that specific announcement as of the archive date. For historical or informational purposes, the FOA remains useful as a template for the kinds of secondary data analysis projects NIH seeks in these disease areas, and similar opportunities sometimes reappear under updated FOA numbers or reissued announcements.
For applicants or readers wanting the full official language, the additional information link is provided as http://grants.nih.gov/grants/guide/pa-files/PA-15-169.html (as written in the source, spacing may need to be corrected when entering it in a browser). Contact support is routed through the NIH Office of Extramural Research (OER) webmaster for access or linking problems, using FBOWebmaster@OD.NIH.GOV.
FAQs: Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21) (PA-15-169)
What is the "Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21)" opportunity?
This is an NIH discretionary grant opportunity (Funding Opportunity Number PA-15-169) designed to support short, exploratory research projects that use secondary analysis of existing data rather than collecting new primary data. It uses the NIH R21 mechanism, which is typically meant for early-stage, innovative, or high-risk/high-reward ideas that can be tested relatively quickly.
What does "secondary analysis" mean in this funding opportunity?
Secondary analysis means the research is based on data that already exist (for example, previously collected clinical, epidemiologic, registry, or health record data) instead of generating brand-new data through new enrollment, new experiments, or new data collection efforts.
What is the main goal of this FOA?
The goal is to facilitate research that explores innovative hypotheses using existing datasets. The emphasis is on asking fresh, creative questions and generating new discoveries without the time and cost of building new cohorts or launching new data collection.
What types of research questions are encouraged?
The opportunity encourages new and creative questions that can be answered with existing datasets, such as identifying predictors, examining subgroups, exploring mechanisms, refining phenotypes, investigating under-studied endpoints already captured in older datasets, applying modern statistical/computational approaches to legacy data, or harmonizing variables across multiple datasets to address questions that a single study could not resolve.
Is this program intended for "standard" re-analyses?
No. The focus is on innovative, well-reasoned secondary research that extracts additional scientific value from prior investments in data collection, rather than simply re-running common or routine analyses.
Which scientific and disease areas are within scope?
The scope is broad and anchored in NIH-relevant diseases and systems, including obesity; diabetes; digestive diseases; and kidney-related conditions, along with related endocrine, metabolic, genetic, nutrition, urologic, and hematologic disease areas described in the FOA summary.
Does the FOA cover endocrine and metabolic diseases beyond diabetes?
Yes. The FOA explicitly encourages work relevant to diabetes and a range of endocrine and metabolic diseases, including thyroid and parathyroid disorders, Cushing's disease, and acromegaly.
Are inherited or genetic metabolic conditions included?
Yes. The FOA includes genetic and metabolic diseases such as cystic fibrosis, lysosomal storage diseases, and disorders involving the urea cycle, amino acid metabolism, and metal transport, particularly where the emphasis is on peripheral metabolism or organ function.
Are liver diseases and gastrointestinal (GI) diseases included?
Yes. The FOA includes liver diseases and diseases of the alimentary gastrointestinal (GI) tract.
Is nutrition research included?
Yes. The FOA includes nutrition-related research within its scientific scope.
Are kidney and urologic diseases included?
Yes. The FOA covers kidney and urologic diseases, and also references hematologic diseases within the listed scope.
What kinds of datasets can be used for the secondary analyses?
Examples mentioned include clinical trial datasets, epidemiologic cohort datasets, electronic health record-derived datasets, disease registries, biobank-linked phenotypic datasets, and other well-characterized existing resources.
Do applicants need to collect new data for this R21?
The central purpose is to support projects that rely on existing data rather than collecting new primary data. The description emphasizes new discoveries driven by reanalysis of already available datasets.
What funding mechanism is used?
This opportunity uses the NIH R21 mechanism.
What is the Funding Instrument Type?
The Funding Instrument Type is a Grant.
What activity categories are associated with this opportunity?
The activity categories listed are Food and Nutrition and Health.
What is the CFDA number associated with this opportunity?
The CFDA number provided is 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
Is cost sharing or matching required?
No. The summary states there is no cost sharing or matching requirement.
What is the award ceiling?
The award ceiling listed in the provided summary information is $200,000.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include public and private institutions of higher education; nonprofits with and without 501(c)(3) status; for-profit organizations other than small businesses; small businesses; and multiple levels of government (state, county, city or township, special district, independent school districts, and public housing authorities/Indian housing authorities).
Are tribal governments and tribal organizations eligible?
Yes. The eligibility list includes Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments).
Are minority-serving institutions included in eligibility?
Yes. The "other eligible applicants" category notes Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are listed under "other eligible applicants."
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligibility description explicitly includes non-domestic entities (foreign organizations).
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed under "other eligible applicants."
Are federal agencies eligible?
Yes. The eligibility notes "eligible federal agencies" under the "other eligible applicants" category.
When was this FOA posted?
The FOA was posted and created on April 1, 2015.
What was the closing date for applications?
The original and current closing date listed is May 7, 2018.
Is this funding opportunity still open?
No. It was archived on June 7, 2018, which indicates the opportunity is no longer open for applications under that specific announcement.
Where can applicants find the official FOA text?
The additional information link provided is: http://grants.nih.gov/grants/guide/pa-files/PA-15-169.html
Who should be contacted for access or linking problems related to the FOA?
Contact support is routed through the NIH Office of Extramural Research (OER) webmaster for access or linking problems at FBOWebmaster@OD.NIH.GOV.
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