Secondary Analyses in Obesity, Diabetes, Digestive and Kidney Diseases (R21) | Apply Online

Opportunity Summary:

The Secondary Analyses in Obesity, Diabetes, Digestive and Kidney Diseases (R21) opportunity (Funding Opportunity Number PA 06 151) is a discretionary NIH grant program run by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It is designed specifically to fund short-term, exploratory research projects that rely on secondary analysis of already-existing data sets, rather than collecting new primary data. The central idea is to help investigators ask fresh, innovative questions using data that have already been gathered, which can make the work faster to launch and more cost-effective while still producing meaningful new insights. A major emphasis of the announcement is research on overweight and obesity, positioned within NIDDKs broader mission areas that include diabetes and other endocrine and metabolic diseases, digestive diseases and nutrition (including obesity and eating disorders), and kidney, urological, and hematological diseases.

This program uses the NIH R21 mechanism, which is typically intended for early-stage, high-impact, or conceptually novel studies where the work is exploratory and may not yet have the extensive preliminary data expected for larger awards. In this case, the R21 is used to encourage analyses that might be difficult to support through other mechanisms, particularly because the research does not require new participant recruitment or new clinical data collection. Projects under this announcement are expected to be short term and focused, aiming to generate new hypotheses, reveal patterns or associations, develop or test analytic approaches, or otherwise extract additional scientific value from existing resources. While the announcement is broad across NIDDK topic areas, it highlights obesity as a prominent subject area, meaning applications that address overweight and obesity using existing data sets are particularly aligned with the stated priorities.

The award ceiling listed for this opportunity is $200,000, and there is no cost sharing or matching requirement, which means applicants are not required to contribute their own funds as a condition of receiving the award. The activity category is listed under Food and Nutrition and Health, and the CFDA number is 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), reflecting its placement within NIDDKs extramural research portfolio. The posting date is March 2, 2006, and the opportunity later moved into archive status with an archive date of June 1, 2009. Receipt dates were described as multiple receipt dates, with applicants directed to the full announcement for the exact schedule and deadlines.

Eligibility for applying is broad and includes many types of domestic organizations such as public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (other than small businesses), and various governmental entities including city or township governments, county governments, state governments, special district governments, and independent school districts. In addition, Native American tribal governments (federally recognized) and other Native American tribal organizations are eligible. Importantly, the eligibility statement explicitly notes that foreign institutions are eligible to apply, and eligible agencies of the federal government are also eligible, which expands the potential applicant pool beyond the typical domestic academic and nonprofit community.

Operationally, the research this program supports is centered on the secondary analysis of existing data sets relevant to NIDDK mission areas. That can include reanalysis of completed clinical trials, cohort studies, population surveys, disease registries, electronic health record-derived research data sets where permitted, biorepository-linked data, or other established databases, as long as the proposed work is ethical, feasible, and scientifically compelling. Because the intent is to enable innovative approaches not readily supported elsewhere, competitive projects would generally be expected to do more than simple replication. They might, for example, apply new statistical methods, harmonize variables across multiple cohorts, evaluate subgroup effects not examined in primary publications, explore novel exposures or outcomes, test mechanistic hypotheses using available biomarkers, or identify predictors of treatment response in obesity or diabetes-related studies.

For applicants seeking more detail, the full announcement was provided through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-06-151.html (spacing and punctuation may need to be corrected when entering the link). For technical difficulties accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, including support for linking problems.

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Previous opportunity: NIH Exploratory/Developmental Research Grant Program (Parent R21)

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