Opportunity Information: Apply for RFA AG 13 008
Apply for RFA AG 13 008
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Secondary Analyses of CALERIE Data Set and Stored Biospecimens to Address Research Questions Related to Effects of Caloric Restriction in Humans and Adherence to Caloric Restriction Interventions (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Aug 17, 2012 and posted on Aug 17, 2012.
- Applicants must submit their applications by Oct 30, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments City or township governments Private institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities County governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
This NIH National Institute on Aging (NIA) funding opportunity (RFA-AG-13-008) supports short-term R01 research projects, lasting up to two years, that make use of existing resources from the CALERIE study (Comprehensive Assessment of Long-term Effects of Restricting Intake of Energy). Rather than funding new participant recruitment or a new clinical trial, the intent is to push forward what can be learned from the already-collected CALERIE data set and/or the stored CALERIE biospecimens through secondary analysis. The overarching scientific purpose is to test clearly defined hypotheses about how sustained caloric restriction (CR) in humans influences aging-related biology and health, including both potentially beneficial effects (protective factors) and potentially harmful effects (risk factors), along with psychological outcomes and overall safety considerations.
The research emphasis is on understanding how long-term reductions in calorie intake affect processes tied to aging and age-associated diseases, and on evaluating adherence to caloric restriction interventions. Projects are expected to be hypothesis-driven and to connect human findings to mechanistic ideas that have emerged from preclinical work, such as animal models and cell culture studies, where caloric restriction has been linked to pathways thought to modulate aging. In practical terms, applicants are encouraged to take specific candidate mechanisms suggested by preclinical research and ask whether the CALERIE human data and biospecimens provide evidence that those mechanisms also appear in people under sustained caloric restriction.
A key theme of the announcement is the preference for integrated, systems-level approaches that capture a broad picture of caloric restriction effects across multiple biological domains at the same time. The NIA explicitly encourages the use of modern high-dimensional screening methods and “omics” style platforms, including proteomics, metabolomics, transcriptomics, and related global profiling strategies. The point is not simply to measure one marker in isolation, but to leverage the richness of the CALERIE repository to evaluate coordinated changes across pathways and systems, which is often necessary for aging research where effects can be subtle, interconnected, and distributed across physiology.
From a funding and administrative standpoint, this is a discretionary grant program using the NIH R01 mechanism, with an estimated total program funding level of about $1,000,000 and an expectation of roughly five awards. The award ceiling is listed as $300,000. Cost sharing or matching is not required. The opportunity was posted on August 17, 2012, with an original (and final) closing date of October 30, 2012, and it was archived on November 30, 2012. The activity category is health, and it falls under CFDA 93.866 (Aging Research), reflecting its focus on aging processes and interventions relevant to aging biology and age-related disease risk.
Eligibility is broad and spans many organization types, including public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses) as well as small businesses, and a wide range of government entities (state, county, city/township, special district, and certain housing authorities). The announcement also specifies additional eligible applicants such as federally recognized and other tribal entities and organizations, Alaska Native and Native Hawaiian Serving Institutions, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. This broad eligibility signals that the NIA is primarily interested in strong analytic and scientific plans for using the CALERIE resources, regardless of the institutional setting, as long as the applicant can responsibly handle the data and/or biospecimens and carry out rigorous analyses.
In short, the opportunity is designed to accelerate discovery from the CALERIE trial by funding focused, time-limited projects that mine the existing human caloric restriction data and biological samples to answer targeted questions about mechanisms, benefits, risks, psychological impacts, safety, and adherence, with a strong preference for comprehensive, multi-system analytic approaches that can reveal how caloric restriction reshapes human biology in ways relevant to aging.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is an NIH National Institute on Aging (NIA) funding opportunity announcement (RFA-AG-13-008) that supports short-term R01 research projects that use existing resources from the CALERIE study (Comprehensive Assessment of Long-term Effects of Restricting Intake of Energy).
What is the main purpose of the program?
The purpose is to accelerate what can be learned from the already-collected CALERIE data set and/or stored CALERIE biospecimens by funding hypothesis-driven secondary analyses on how sustained caloric restriction (CR) in humans affects aging-related biology, health, psychological outcomes, adherence, and safety.
What kind of projects does the NIA want to fund?
Projects are expected to be clearly hypothesis-driven and focused on testing well-defined questions about sustained caloric restriction in humans, including potential protective effects, potential risk factors, psychological outcomes, and overall safety considerations.
How long can projects last?
Projects are short-term R01s lasting up to two years.
Is this opportunity for running a new clinical trial or recruiting new participants?
No. The intent is not to fund new participant recruitment or a new clinical trial. The focus is on secondary analysis using existing CALERIE data and/or stored biospecimens.
What resources are applicants expected to use?
Applicants are expected to use existing CALERIE study resources, specifically the already-collected data set and/or stored CALERIE biospecimens, to conduct secondary analyses.
What scientific topics are in scope?
In-scope topics include how sustained caloric restriction influences aging-related biology and health, the balance of beneficial (protective) versus potentially harmful (risk) effects, psychological outcomes, adherence to caloric restriction interventions, and safety considerations.
What is meant by linking human findings to preclinical mechanisms?
The announcement encourages applicants to take candidate mechanisms suggested by preclinical work (such as animal models and cell culture studies) and test whether CALERIE human data and biospecimens show evidence consistent with those mechanisms in people undergoing sustained caloric restriction.
Does the announcement favor any particular analytic approach?
Yes. A key theme is a preference for integrated, systems-level approaches that assess multiple biological domains at the same time, rather than focusing on a single isolated marker.
Are "omics" and high-dimensional methods encouraged?
Yes. The NIA explicitly encourages modern high-dimensional screening methods and "omics" platforms, including proteomics, metabolomics, transcriptomics, and related global profiling strategies, to evaluate coordinated changes across pathways and systems.
Why does the announcement emphasize multi-system, coordinated analyses?
The opportunity highlights that aging-related effects can be subtle, interconnected, and distributed across physiology. Systems-level analyses can help detect coordinated pathway and system changes that may be missed when measuring only one marker in isolation.
What grant mechanism is being used?
The program uses the NIH R01 research project grant mechanism.
How much total funding is expected for the program?
The estimated total program funding level is about $1,000,000.
How many awards are expected?
The announcement indicates an expectation of roughly five awards.
Is there an award ceiling?
Yes. The award ceiling is listed as $300,000.
Is cost sharing or matching required?
No. Cost sharing or matching is not required.
When was this opportunity posted, and what were the dates?
It was posted on August 17, 2012. The original (and final) closing date was October 30, 2012. It was archived on November 30, 2012.
Is this funding opportunity still open?
No. Based on the provided information, the opportunity had a final closing date of October 30, 2012 and was archived on November 30, 2012.
What is the activity category and CFDA number?
The activity category is health, and it falls under CFDA 93.866 (Aging Research).
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (including small businesses and for-profit organizations other than small businesses); and many government entities such as state, county, city/township, special district, and certain housing authorities.
Are tribal and minority-serving institutions included in eligibility?
Yes. The announcement specifies additional eligible applicants including federally recognized and other tribal entities and organizations; Alaska Native and Native Hawaiian Serving Institutions; Historically Black Colleges and Universities (HBCUs); Hispanic-serving institutions; Tribally Controlled Colleges and Universities (TCCUs); and U.S. territories or possessions.
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are listed among eligible applicants.
Are regional organizations and federal agencies eligible?
Yes. Regional organizations and eligible federal agencies are included among eligible applicants.
Does broad eligibility mean the NIA is mainly focused on the quality of the science plan?
Based on the description provided, the broad eligibility suggests the NIA is primarily interested in strong analytic and scientific plans that responsibly use CALERIE data and/or biospecimens to produce rigorous, hypothesis-driven findings.
What are examples of outcomes the research might address?
The announcement highlights outcomes related to aging-related biology and health, protective versus harmful effects, psychological outcomes, adherence to the caloric restriction intervention, and overall safety considerations.
Is the goal to study caloric restriction broadly, or specifically sustained caloric restriction in humans?
The emphasis is specifically on sustained caloric restriction in humans, using the CALERIE trial resources to test hypotheses about mechanisms and outcomes relevant to aging.
What does the opportunity aim to achieve overall?
Overall, it is designed to accelerate discovery from the CALERIE trial by funding focused, time-limited projects that mine existing human caloric restriction data and samples to answer targeted questions about mechanisms, benefits, risks, psychological impacts, safety, and adherence, with a preference for comprehensive, multi-system analytic approaches.
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